1 / 14

Sickle Cell Disease Neil Grossman, MD Professor, Department of Pediatrics University of Maryland School of Medicine 9

Sickle Cell Disease. Hemoglobin Types:A1: ?2?2A2: ?2?2F: ?2?2. Sickle Cell Disease. Sickle Hemoglobin:?2 ?2 6 GLU?VAL. Sickle Cell Disease. Hemoglobin Electrophoresis:pH 8.2AFSCpH 6.2CSAF. Newborn Screen . RESULTINTERPRETATIONFA AANormal F

hisano
Download Presentation

Sickle Cell Disease Neil Grossman, MD Professor, Department of Pediatrics University of Maryland School of Medicine 9

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

    1. Sickle Cell Disease Neil Grossman, MD Professor, Department of Pediatrics University of Maryland School of Medicine 9-27-2006

    2. Sickle Cell Disease Hemoglobin Types: A1: ?2?2 A2: ?2?2 F: ?2?2

    3. Sickle Cell Disease Sickle Hemoglobin: ?2 ?2 6 GLU?VAL

    4. Sickle Cell Disease Hemoglobin Electrophoresis: pH 8.2 A F S C pH 6.2 C S A F

    5. Newborn Screen RESULT INTERPRETATION FA AA Normal FAS AS Sickle Trait FAC AC C Trait FAD AD D Trait FAE AE E Trait FS SS Sickle Cell Disease FSC SC Sickle-C Disease

    6. Sickle Cell Disease Incidence SS 1:625 SC 1:1000

    7. Sickle Cell Disease Incidence Trait and Disease: 8-10% of African-Americans Disease: 0.3-1.3% of African- Americans

    8. Sickle Cell Disease Mendelian Inheritance Autosomal Recessive

    9. Sickle Cell Disease Variants SS: 65% SC: 21% S-?+thal: 5-7% S-?othal: 5-7% Others

    10. Sickle Cell Disease Crisis/Episode Vaso-occlusive Sequestration Aplastic Hyperhemolytic Fever/Infection

    11. Sickle Cell Disease Crisis/Episode Vaso-occlusive Sequestration Aplastic Hyperhemolytic Fever/Infection

    12. Sickle Cell Disease Crisis/Episode Vaso-occlusive Sequestration Aplastic Hyperhemolytic Fever/Infection

    13. Sickle Cell Disease Crisis/Episode Vaso-occlusive Sequestration Aplastic Hyperhemolytic Fever/Infection

    14. Sickle Cell Disease Crisis/Episode Vaso-occlusive Sequestration Aplastic Hyperhemolytic Fever/Infection

    15. Sickle Cell Disease Crisis/Episode Vaso-occlusive Sequestration Aplastic Hyperhemolytic Fever/Infection

More Related