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Elevated liver enzymes following polytraumatic injury

Study on factors associated with liver enzyme elevation in TBI patients at McGuire VA Medical Center. Findings showed commonality in enzyme elevations with no defined etiology. Further analysis needed to determine efficient monitoring and management strategies.

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Elevated liver enzymes following polytraumatic injury

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  1. Elevated liver enzymes following polytraumatic injury Aaron Fox, MD; James B. Sanderlin, MD; Shane McNamee, MD; Jasmohan S. Bajaj, MD; William Carne, PhD; David X. Cifu, MD

  2. Aim • Describe and examine factors associated with mild liver enzyme elevations in patients with traumatic brain injury (TBI). • Relevance • This information may help clinicians evaluate and manage individuals with TBI found to have elevated liver enzymes.

  3. Method • Participants were servicemembers with TBI admitted to Hunter Holmes McGuire VA Medical Center Polytrauma Rehabilitation Center. • January 2008 through December 2011. • We retrospectively analyzed and categorized patients based on alanine aminotransferase (ALT) values (above or below 44 IU/L) on initial labs.

  4. Results • Of 121 subjects, 59 (49%) had ALT ≥44 IU/L. • No significant differences between groups with regard to sex, military status, race, theater, TBI mechanism, severity of TBI, or concomitant injuries. • Regardless of demographics, mechanism of injury, or extent of trauma, elevated liver enzymes were common. • Enzymes typically returned to normal with conservative management. • No specific etiology was defined in most cases.

  5. Conclusion • Further analysis will be performed to determine most efficient way to monitor these patients so that unnecessary tests are avoided and medical expenses are minimized.

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