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ABSTRACT Study of lipophilic property (Rm), electronic property (pKa), steric property

ABSTRACT Study of lipophilic property (Rm), electronic property (pKa), steric property (RM) of Cefadroxil and Cephradine and their Antibacterial Activities against Staphylococcus aureus ATCC 25923 The research to study of lipophilic (Rm), electronic (pKa), steric

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ABSTRACT Study of lipophilic property (Rm), electronic property (pKa), steric property

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  1. ABSTRACT Study of lipophilic property (Rm), electronic property (pKa), steric property (RM) of Cefadroxil and Cephradine and their Antibacterial Activities against Staphylococcus aureus ATCC 25923 The research to study of lipophilic (Rm), electronic (pKa), steric characteristic (RM) and antibacterial activities at Staphylococcus aureus ATCC 25923 from cefadroxil and cephradine was aim to find the influence of this physicochemical characteristic of the compound on the antibacterial activities. Rm values were determined by Reversed Phase Thin Layer Chromatography method with acetone-water (80:20) as mobile phase. pKa values were determined by uv-spectrofotometry method by using solution of compound in various pH. RM values of cefadroxil and cephradine were determined by measuring the refractive index and density of the compound solution in metanol at definite concentration and temperature. The antibacterial activity were tested by dilution method to get MIC (ppm) of cefadroxil and cephradine against Staphylococcus aureus ATCC 25923. The result of antibacterial activity test showed that MIC of cefadroxil and cephradine against Staphylococcus aureus ATCC 25923 were 16,00 ppm and 8,00 ppm. The Rm values of cefadroxil and cephradine were 0,15 and 0,19. The pKa values of cefadroxil and cephradine were 4,76 and 2,51, and the Molar Refraction of cefadroxil and cephradine were 94,11 cc/mol and 101,08 cc/mol. The result showed that cephradine which had higher lipophilicity, high ionization constant, and big molar volume gave higher antibacterial activities than cefadroxil. Keywords : Retention Modified (Rm), ionization constant (pKa), Molar Refraction (RM), cefadroxil, cephradine , antibacterial activities, Staphylococcus aureus ATCC 25923.

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