The Tenure and Promotion CV: Relationships are the Common Thread

1. The Tenure and Promotion CV: Relationships are the Common Thread Alyssa Hasty, PhD Associate Professor Molecular Physiology and Biophysics

2. Tenure and Promotion Criteria • Research, Scholarship or Creative Expression • Teaching • Service

3. Tenure and Promotion Criteria • Research, Scholarship or Creative Expression • Teaching • Service National Reputation

4. The T & P Packet • CV (formatted according to their guidelines) • Documentation of Teaching Form • Critical References (description of your 5 most important papers and why they impacted the field) • Letters of Evaluation (minimum of 5) • Letter from Chair/Chief of your department https://medschool.vanderbilt.edu/faculty/details-appointments-and-promotions#supportdocs

5. Teaching Form • A. MEDICAL SCHOOL COURSES. • B. GRADUATE SCHOOL COURSES. • C. CONTINUING EDUCATION. • D. RESEARCH SUPERVISION. • E. CLINICAL TEACHING. • G. PRIMARY TEACHING ROLE (S).

7. You will need letters from trainees (who are no longer in your lab) The number differs by department

8. Critical References

9. Critical References • Please specify up to five references which represent the candidates most significant contributions. If the candidate if not first author, specify the role played by the candidate in the work described by these key publications. • “I have chosen the 5 most important and impactful papers out of 14 papers on which I am the senior corresponding author. These papers demonstrate the focus of my research program on mechanisms by which lipids induce macrophage inflammation. These inflammatory macrophages promote atherosclerotic lesion expansion when they are present in the arterial intima and insulin resistance when they are present in adipose tissue.”

10. Tell them ALL the reasons why these papers were important • How did they change our scientific knowledge? • Did they help you obtain grant funding? • Did they help establish a collaboration? • Did they bring you name recognition in some other way?

11. Literature Citation #1. Names of all authors as listed sequentially on the publication: Title:   Role of Candidate: I am the senior, corresponding author on this manuscript. The experiments were performed by Saraswathi Viswanathan, a post-doctoral fellow in my laboratory at that time. I was responsible for interpretation of the data. The manuscript was drafted by Dr. Viswanathan, and finalized and submitted by myself.

12. This manuscript describes our observation that very low density lipoproteins (VLDL) induce inflammatory cytokine production in macrophages. In particular, we studied the time course and dose response expression of the chemokine, macrophage inflammatory protein-1α (MIP-1α). Furthermore, we showed that the increase in inflammatory gene expression coincided with the phosphorylation of the MAPK pathway members: ERK1/2, JNK, and p38 MAPK, and was ameliorated by U0126, an inhibitor of ERK1/2. Finally, inhibition of extracellular TG hydrolysis with Orlistat resulted in the absence of intracellular TG and FFA accumulation and was accompanied by the amelioration of ERK1/2 phosphorylation and MIP-1α gene expression. These results are important because hypertriglyceridemia is a hallmark characteristic of obesity-related dyslipidemia, and macrophages play a critical role in both atherosclerotic lesion formation and insulin resistance. Thus, we concluded that elevations in TG-rich VLDL may contribute to the pathogenesis of obesity by increasing inflammation in macrophages. These studies helped lay the foundation for both my American Diabetes Association grant to study MIP-1α in atherosclerosis and insulin resistance, as well as my NIH R01 to study the role of fatty acids in macrophage accumulation in adipose tissue.

13. These data have important implications to the pathogenesis of diet-induced obesity in humans, even when plasma lipid abnormalities are not present. This publication was also instrumental in helping me obtain my R01. In addition, they brought me recognition in the field of macrophage infiltration into AT, and I was subsequently asked to write two review articles on the topic.

14. Development of this mouse model has led to a collaborative effort between my laboratory and Drs. Judy Aschner, Jeff Reese, and BC Paria to study the impact of maternal obesity on the cardiovascular outcomes in the offspring. We have obtained P&F funding for this project and are currently obtaining preliminary data in order to submit a multi-PI NIH R01 application next year. In addition, Dr. Coenen and I will be writing a review article on mouse models of the metabolic syndrome to be submitted to the journal Disease Models and Mechanisms this Fall.

15. This publication has lead to the development of 4 new collaborations for my lab. (1) We are collaborating with Dr. Charles Wilkins at the University of Arkansas to assess phospholipid levels in tissues from these mice, and have a manuscript in submission. (2) We are collaborating with Dr. Alan Tall at Columbia University to determine the effect of fish oil on the phagocytic index of arterial macrophages. (3) We are collaborating with Dr. Edward Fisher at New York University to determine whether fish oil impacts apoB aggregation in liver. (4) We are collaborating with Dr. Naima Moustaid-Moussa at the University of Tennessee Knoxville to determine whether fish oil impacts adipose tissue expression of genes involved in the renin angiotensin system.

16. External reviewers

17. List of Potential External Reviewers • “Nationally recognized leaders in relevant area of scholarship” • Colleagues but NOT collaborators • Someone in the same research group as a collaborator • Someone who has followed your career and has an interest in seeing you succeed • Head of similar department as yours • Could they say, “this person would certainly be given T&P at my University” – be aware of other University T&P policies. • “The most frequent reason for deferral of Committee action is the need to request additional information from additional correspondents.”

18. Daniel Rader, MD University of Pennsylvania School of Medicine Theodore Mazzone, MD Professor of Medicine, University of Illinois at Chicago Chief, Section of Diabetes and Metabolism MC 797 Alan Daugherty, PhD, D.Sc. Professor of Medicine and PhysiologyGill Foundation Chair in Preventive CardiologyDirector, Cardiovascular Research Center  Jay Heinecke, PhD Professor of MedicineDivision of Metabolism, Endocrinology and Nutrition University of Washington School of Medicine Murray Huff, PhD Professor, Departments of Medicine and Biochemistry University of Western Ontario Ira Tabas, MD. PhD Professor of Medicine and Anatomy & Cell Biology, Department of MedicineColumbia University

19. CV https://medschool.vanderbilt.edu/faculty/suggested-format-curriculum-vitae

20. Basics • Include all sections, even if N/A • Follow SOM guidelines carefully • Within these guideline, make as aesthetically pleasing as possible • Don’t assume the reviewers will know abbreviations that are common in your field • There may be several months between when your department T&P committee meet to when your package is sent to the University T&P committee –submit your most current CV

21. SOM Guidelines • Name • Education • Licensure and Certification • Academic Appointments • Hospital Appointments • Employment • Professional Organizations • Professional Activities • Teaching Activities • Other Activities • Research Program • Publications and Presentations (separate by category) https://medschool.vanderbilt.edu/faculty/details-appointments-and-promotions#guidelines

22. MY CV

23. Research, Scholarship or Creative Expression (National Recognition) Invitations to speak

24. Ways to get speaker invitations • Because a senior investigator at another institution cares about your career • “Trade” invitations • Invite yourself • As part of collaboration • Out of the blue

25. My invited seminars • 2002 – 1 • 2003 – 1 • 2006 – 3 • 2007 – 5 • 2008 – 5 • 2009 - 2 Only 4 of 17 were from people I did not know

26. Keep in touch with people you knew as a grad student and post-doc

27. I’ve maintained “mentoring” relationships with several of my mentor’s colleagues • Alan Daugherty • Invitation to speak at UK • Invitation to speak at ATVB • Invitation to speak at Gordon Conference • Invitation to be on ATVB planning committee

28. Network with people you meet at Study Section

29. Carole Stzalryd • 2003-2007 American Heart Association Southeast/OhioValley Chapter Grant Committee (met Carole Stzalryd) • We traded invitations • 12/04/08 University of Maryland. Clinical Nutrition Research Unit Seminar.

30. Suzanne Mohr • 2003-2007 American Heart Association Southeast/OhioValley Chapter Grant Committee (met Suzanne Mohr) • 12/10/07 Case Western Reserve University - Diabetes Research Seminar.

31. Network with people you meet at conferences

32. Pete Bodary • Met Pete Bodary at ATVB conference in 2006 • We traded invitations • 04/17/07 Wayne State University - Nutrition and Food Sciences Seminar Series.

33. Heddwen Brooks • Met Heddwen Brooks at a Women’s Faculty Leadership conference • We traded invitations • 10/13/06 University of Arizona – Diabetes Seminar Series.

34. Network with guest speakers to Vanderbilt

35. Alan Chait Jay Heinecke • Met Alan Chait who spoke in DRTC seminar series • I initiated a collaboration and “invited myself” to visit with him to discuss • 11/15/07 University of Washington - Endocrinology Research Conference. • Met Jay Heinecke at U Wash and again at a Gordon Conference

36. Martin Meyers Susan Fried • Met Martin Meyers who spoke in MPB seminar series • 10/11/07 University of Michigan - Division of Metabolism, Endocrinology, and Diabetes Seminar Series. • He won an award at the Obesity Conference last year and invited me to a party. I met Susan Fried there who is the current chair of the Obesity Society and asked me to speak at their next annual meeting.

37. Research, Scholarship or Creative Expression (National Recognition) Publications

38. SOM Guidelines • Articles in refereed journals: List chronologically • Books, book chapters, invited review articles • Letters to editor, book reviews, editorials (optional) • Abstracts (optional) • Presentations at Scientific Meetings

39. SOM guidelines • Separate by category • Doesn’t say you can’t include “In Submission” or “In Revision” • I would not include “In Preparation”

40. My CV Total From 2003 27 original 2 reviews 1 book chapter 17 were from my lab • 56 original • 2 reviews • 1 book chapter • 23 were first author or from my lab

41. Research, Scholarship or Creative Expression (National Recognition) grants

42. My Grants • Previous P&Fs and Junior Faculty Grants • ADA Career Development Award • R01 • Choice of Study Section and NIH Institute is VERY important

43. Things I think I did well • Found an exceptional lab manager who has been with me since day 1 • Spent my development funds to hire people so that I published fairly early • Wrote for and obtained junior faculty grants early • My development funds lasted longer • Showed evidence of obtaining funding • Department paid to have my R01 read by outside person • Used my mentoring committee for advice

44. Things I learned the hard way • The wrong person is not better than no person. • Even while working on projects you have funded, look toward the future of where your field will be going next. • If you are moving away from a certain direction, finish and publish those studies as quickly as possible. • Do NOT avoid conflict – especially if it is with someone in your lab group.

45. Final Tips • Find out who is on the T&P committee and talk to them about your CV • Set up a meeting with Dr. Penn or Dr. Raiford to talk about your CV • You NEED someone on your side in your department for when you are discussed! • Reserve time on your calendar to read/write • Pay it forward.