1 / 27

Med- 1 Protontherapy and microdosimetry with the Geant4 toolkit

Med- 1 Protontherapy and microdosimetry with the Geant4 toolkit. Se Byeong Lee – National Cancer Center, Goyan , Korea Sébastien Incerti – IN2P3/CENBG, France o n behalf of the Med- 1 team. TYL-FKPPL Joint Workshop, Seoul, June 4-6, 2013. Outline. Context

honorato-mcgowan
Download Presentation

Med- 1 Protontherapy and microdosimetry with the Geant4 toolkit

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Med-1Protontherapy and microdosimetrywith the Geant4 toolkit Se Byeong Lee – National Cancer Center, Goyan, Korea Sébastien Incerti – IN2P3/CENBG, France on behalf of the Med-1 team TYL-FKPPL Joint Workshop, Seoul, June 4-6, 2013

  2. Outline • Context • Extend and evaluate Geant4 performance for protontherapy and microdosimetryin the context of protontherapy • Proposedworkplan for 2013 • EvaluateGeant4 performance for protontherapy • Modelling of geometries for plasmid irradiation • Performirradiation of pBR322 plasmidsat NCC with 230 MeV protons at NCC • Continue verification & validation of Geant4-DNA physicsmodels • Collaboration matters

  3. Med 1 triangular collaboration IN2P3/CENBG Geant4 “low energy” EM Geant4-DNA NCC Protontherapy MC simulation & track structure modeling Experiments on proton beam IN2P3/LPC Clermont GATE/Geant4-DNA modeling for protontherapy Biology experiments

  4. 1) Geant4 perfomance for protontherapy simulation

  5. Proton beam facility in National Cancer Center IBA Proteus 235 Weight : 220 ton Height : 210 cm Diameter : 434 cm Energy : 230 MeV Max. extracted beam current : 300 nA RF frequency : 106 MHz

  6. Evaluate for Geant4 perfomance for protontherapy simulation • Objectives • Deliver benchmark data for Bragg peak profiles • in liquid water, • longitudinal & lateral profiles, at entrance, near peak and tail • at a selection of proton energies • Perform monthly regression tests for the non-public monthly releases of Geant4 • NCC joined the Geant4 collaboration in September 2012, in the “Low Energy EM WG” • Prior to public Geant4 releases (twice a year)

  7. Measurements at NCC 3D water phantom with moving Markus chamber Proton therapy room

  8. Simulation application • Simulation application based on the Geant4 electromagnetic test #44 for Bragg peak simulations (non-public) • Easy to modify in order to implement a simple nozzle geometry and General Particle Source feature for the generation of incident beam phase space • This application will be maintained on a monthly basis from the CERN SVN repository • Allows to study the impact of Physics components combination using modular physics list: • Electromagnetic : Option_0, 3 and 4, Livermore, Penelope • Hadronic: FTFP_BERT, QBBC Int. J. Rad. Biol. 88, 171-175 (2012)

  9. Example of longitudinal profiles Measurement using water phantom Geant4 simulation Enlargement of lateral profile

  10. Preliminary results Geant4 water phantom simulation Validation Geant4 Measurement Percent Depth Dose Depth profile Simulation of 53000 protons Physics:QGSP_BIC,EMstandardOpt3,… Using NCC proton nozzle simulation with Geant4 9.6

  11. Regional comparison Comparison in beam entrance region Comparison in Bragg peak region Measurement Geant4

  12. Preliminary results Lateral dose distribution from water phantom measurement 2D dose distribution comparison between Simulation and Measurement Depth (cm) Percent Depth Dose Depthprofile lateral profile lateral profile Percent Depth Dose

  13. 2D dose distribution comparison between Simulation and Measurement near Bragg peak

  14. 2) Verification & validation of Geant4-DNA

  15. Liquid water Verification • Verification = comparison to recommendations & other simulation software • During Med 1 activity, we recently published CTMC cross section models for protons and hydrogen in liquid water and DNA bases (A, T, G, C) • Protons : single capture, single ionization, transfer ionization (new process), double ionization (new process) • Neutral hydrogen : single ionization, stripping • We are now comparing • stopping powers • ranges • mean deposted & transferred energies • in liquid water and DNA material • Once verified, the models will be made publicly available in Geant4-DNA Adenine Nucl. Instrum. Meth. B in press (2013)

  16. Validation • Validation = comparison to experimental results • Geant4-DNA physics and physico-chemistry modelling capabilites should be validated experimentally on ‘simple’ biological targets • made of liquid water and/or DNA material • in dry and hydrated conditions • We propose to irradiate DNA plasmids at NCC with few hundred MeV protons • a circular double-stranded DNA purified • grown from bacteria • This will allow the experimental quantification of DNA damages (SSBs & DSBs) and comparison to Geant4-DNA simulations http://sandwalk.blogspot.com

  17. Plasmid irradiation • pBR322 • 4361 base pairs • Fully known base sequence • Two irradiation conditions • Irradiation of dry DNA layers → direct effects • Irradiation of DNA plasmids in water buffer → indirect + direct effects • 230 MeV protons at NCC • Irradiation protocol developed at Nuclear Physics Institute of Prague (M. Davidkova et al.) for the ESA AO7146 project

  18. Measurement of DNA damage in plasmids DSB DSB Supercoiled SSB SSB SSB Circular relaxed Linear *SSB DSB *SSB Degraded M. Davidkova, NPI DNA plasmids 0.5 - 10 kbp in size Diferentplasmidconformationsafterirradiationcan be easily separated by agarosegelelectrophoresis

  19. Agarose gel electrophoresis 1 2 3 1 2 3 Well - relaxed Direction of migration linear supercoiled + Plasmid dimer relaxed supercoiled Circular relaxed linear Linear Supercoiled Increasing dose M. Davidkova, NPI The DNA is stained with a fluorescent dye(ethidium bromide, SYBR green) The full biologyprotocolwillbeestablished on June 21st at Toulouse / Paul Sabatier U.

  20. Simple parametrized 300 bp circular Example of Geant4-DNA plasmid geometry V. Stepan – CENBG ESA BioRad II

  21. 3) Outreach

  22. Outreach • 51th Particle TheraphyCo-operative Group (PTCOG) conference in Seoul on May 14-19th, 2012 • 3 communications on GATE/Geant4 & Geant4-DNA • Strongsupport of FKPPL to the organization of reular Geant4 and GATE tutorials in Korea : 2009, 2010, 2011 • Recent tutorial • Geant4 Tutorial - October 29 – November2, 2012 - KISTI, Seoul, S. Korea • A new Geant4 tutorial willbeorganized in 2013 in Seoul : dates to beselected KISTI, 2012

  23. Med-1 collaboration matters

  24. Participants

  25. Budget request for 2013 • Requestfrom France to FKPPL • 2 French visitorsto NCC (a week) • 1 Koreanvisitorto CENBG (a month) • Participation of Dr Jeongto Geant4 2013 International Conferenceat the Physiqcs-Medicine-Biologyfrontier in Bordeaux • Requestfrom Korea made to NCC • 1 participation to the Geant4 2013 collaboration meeting (Sevilla, Spain – September 2013) • Note: wealreadybenefitfromfunding by CampusFrance PHC STAR « PROTEUS » project (2012-2013, coord.: S. Incerti) for 3 visitsof French collaborators to Korea in 2013 (6.5 keuros).

  26. Geant4 International Conference at the Physics-Medicine-Biology frontier http://geant4.in2p3.fr/2013/ 7-11 October 2013BordeauxFrance Takashi Sasaki - KEK Se Byeong Lee – NCC RepresentingJapan and Korea Full papers in Phys. Med. Biol.

  27. Thank you National Center for Cancer Prevention and Early Detection NCC Proton Therapy Center Research Institute Hospital

More Related