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Using Genetic Information to Improve Health

Using Genetic Information to Improve Health . Discoveries in Human Genetics. What we Know…. What we Don’t Yet Know…. Preventing Disease & Improving Health. Terminology. Environmental risk factors : All exogenous factors – chemical, physical, infectious, nutritional

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Using Genetic Information to Improve Health

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  1. Using Genetic Information to Improve Health Discoveries in Human Genetics What we Know….. What we Don’t Yet Know….. Preventing Disease & Improving Health

  2. Terminology • Environmental risk factors: All exogenous factors – chemical, physical, infectious, nutritional • Prevention: The use of environmental interventions to reduce the risk of disease among people susceptible because of their genetic make up – not the effort to prevent the birth of infants with specific genotypes

  3. Determinants of Health & Disease Keys to Longevity: • Cigars • Afternoon naps • Bridge with buddies • A couple of martinis each day George Burns 1896-1996

  4. Determinants of Health & Disease Jim Fixx 1932 - 1984

  5. The Integration of Genetics into Public Health: A Blueprint • The Future of Public Health (IOM) • Tool to promote dialog, assist integration, and inform others Public Health Functions Project (1994)

  6. The Integration of Genetics • Assessment: The regular systematic collection, assembly, analysis, and dissemination of information, including genetic epidemiologic information, on the health of the community.

  7. The Integration of Genetics • Policy Development: The formulation of standards and guidelines, in collaboration with stakeholders, which promote the appropriate use of genetic information and the effectiveness, accessibility, and quality of genetic tests and services.

  8. The Integration of Genetics • Assurance: The assurance to constituents that genetic information is used appropriately and that genetic tests and services meet agreed upon goals for effectiveness, accessibility, and quality.

  9. The Integration of Genetics • System Management: Building and maintaining the capacity of the public health infrastructure to integrate genetic information into public health research and practice.

  10. The Integration of Genetics • Research: A systematic investigation designed to develop or contribute to generalizable knowledge of the impact of human genetic variation on health and disease.

  11. Genetics and Public Health:Key Points • Human diseases result from gene-environment interaction • Public health leadership to translate gene discoveries • Integrating genetics into assessment, policy development and assurance • Public health planning to build genetics capacity and train the workforce

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