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STATUS, POTENTIALS AND CHALLENGES OF BIOTECHNOLOGY DEVELOPMENT IN NEPAL

STATUS, POTENTIALS AND CHALLENGES OF BIOTECHNOLOGY DEVELOPMENT IN NEPAL. Dr. Kayo Devi Yami RONAST. TRADITIONAL BIOTECHNOLOGIES.

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STATUS, POTENTIALS AND CHALLENGES OF BIOTECHNOLOGY DEVELOPMENT IN NEPAL

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  1. STATUS, POTENTIALS AND CHALLENGES OF BIOTECHNOLOGY DEVELOPMENT IN NEPAL Dr. Kayo Devi Yami RONAST

  2. TRADITIONAL BIOTECHNOLOGIES • For many centuries societies and communities have been using these technologies to alter plants & animal products to produce BETTER FOOD & IMPROVED PRODUCTION without knowing the actual scientific background. • DAIRY PRODUCTS (Cheese, Churpi, Curd etc.) • FERMENTED VEGETABLE PRODUCTS (Gundruk, Sinke, Pickles etc.) • BREWERY TECHNOLOGY(Raksi, Jand, Tomba etc.) • PLANT BREEDING

  3. MODERN BIOTECHNOLOGY • MUSHROOM PRODUCTION • TISSUE CULTURE • BIOFERTILIZERS • BIOPROSPECTING • BIOLOGICAL CONTROL • VACCINE PRODUCTION

  4. PLANT TISSUE CULTURE • GOVERNMENT SECTOR • Department of Plant Resources • Thapathali • produced 100,000 plantlets of disease free Banana & Citrus. • Tissue culturing of Rauwolfia, Eucalyptus & Jerbera, Swertia, Dalbergia etc Godawari • Pioneer Tissue Culture Lab • research & development; > 100 protocols for plant tissue culture so far • In situ and ex situ conservation of germplasm of improtant medicinal plants

  5. National Agricultural Research Council • Potato tissue culture lab producing 200,000 virus free pre-basic potato seeds/year • Agricultural Botany Division has initiated anther culture of rice and wheat & also germplasm conservation and diagnostic facilities using PCR technology • Dhankuta & Lumle Agriculture Stations also have tissue culture lab facilities

  6. Horticulture Development Project of Department of Agriculture, Kirtipur • very good facilities for plant tissue culture work (Japanese Grant), once produced in vitro plantlets of apple rootstocks Institute of Agriculture & Animal Sciences, Rampur • plant tissue culture lab facilities (Rockfeller Foundation) but is limited to MSc thesis work only

  7. PRIVATE SECTORS • Botanical Enterprises Pvt. Ltd., Godawari • Nepal Biotech Nursery, Bhainsepati • Research Laboratory for Agriculture Biotechnology & Biochemistry (RLABB), Balkhu • Microplants, Kamal Pokhari • Green Research & Technology (GREAT), New Baneshwor • Himalayan Botanical Research Centre (HIMBORCE), Baneshwor

  8. BIOFERTILIZERS • Division of Soil Science & Agriculture Chemistry, Nepal Agricultural Research Council (NARC), Khumaltar: Commercial production of microbial inoculants like rhizobia, Azotobacter. • Royal Nepal Academy of Science & Technology (RONAST), Khumaltar: Research on microbial inoculants like rhizobia, Azotobacter, Endo & Ectomycorrhiza, composting, vermicomposting

  9. MUSHROOM PRODUCTION • Nepal Agricultural Research Institute (NARI), Plant Pathology Division, Khumaltar: spawn for button mushroom, research to develop better substrate for better mushroom production and providing training on mushroom cultivation • Agriculture Technology Centre, Gwarko producing spawn for Agaricus bisporus, Sitake (Lentinus edodes), Gyanoderma • Many unregistered private companies producing mushrooms and spawn • RONAST: study of mushroom diversity in Sagarmatha National Park (CNR) • DPR: Collection and identification of Nepalese mushrooms around Godawari

  10. BIOLOGICAL CONTROL RONAST has been doing research on • BIOPESTICIDES specially of plant origin (Eupatoriumadenoforum, Lantanacamara, Acorus calamus & Ageratumconyzoides) in collaboration with Department of Agriculture against Aphids • BIOINSECTICIDES indigenious strains of Bacillusthuriengensis • BIOFUNGICIDES compost & vermicompost tea solution on Foot rot disease of rice and use of above pesticidal plants against club root disease of cauliflower

  11. BIOPROSPECTING • RONAST has been doing bioprospecting of Himalayan conifers, Cordycepssinensis (Yarchagumba) and Taxusbacatta for their antitumor compounds. • DPR: phytochemical screening of 12 plant spp. & their antifertility and antihelminthic potential and toxicity test on mice • TU Chemistry Division: MSc research work • Simhadurbar Baidhya Khana: Crude form of bioprospecting for ayurvedic medicine

  12. ADVANCED MODERN BIOTECHNOLOGY • RONAST • MOLECULAR DIAGNOSTICS (HLB CITRUS DISEASES) • MOLECULAR CHARACTERIZATIONS OF: • Bacillusthuriengensis • Medicinal plants like Swertia • Tea clones • GMOs

  13. NARC • Genetic diversity analysis of isoenzymes in rice, barley, buckwheat, pigeon pea, taro, cucumber, Sweria, Citrus. • Application of molecular markers towards development of varities and hybrid in maize • RECAST • Selection of genotypes of Mulberry & exploitation of genetic yield potential of common Buckwheat ecotypes.

  14. ANIMAL BIOTECHNOLOGY • Central Veterinary Laboratory, Tripureshwor producing vaccine against P.P.R (Pestes des petites Ruminant) disease using tissue culture, rabies vaccine with Japanese grant also exporting to other countries, poultry vaccine, PCR used in disease diagnostic. • NARC has been doing animal breeding, embryo transfer and artificial insemination in cattles.

  15. MEDICAL BIOTECHNOLOGY • The Leprosy Mission, Nepal: determination of cytokines by ELISA for blood immune response studies in leprosy patients & DNA diagnosis of Mycobacterium leprae by PCR • Everest Biotech Pvt. Ltd.: production of specific antibody required for Human Genome Project, England. • TU Teaching Hospital, Maharajgunj: had used PCR for TB bacteria research work

  16. TU Teaching Hospital: 3 PCRs mainly used for detecting respiratory viruses for the research purpose only • Kathmandu University Medical School: Korean visiting scientist once tried to identify AIDS virus by using RT PCR but because of the problem in water the project could not be initiated.

  17. EXISTING MANPOWER

  18. MANPOWER DEVELOPMENT • Bachelors level (BSc) : Tribhuvan University, Kathmandu University and many private campuses have been delivering BSc courses in Biotechnology. • Masters level (MSc) : Tribhuvan University is going to open MSc courses in Biotechnology from middle of 2006 NOTE : National Planning Commision has provided $ 2,00,000 to KU for BSc & $ 70,000 to TU for MSc programmes.

  19. BUDGET (RONAST)

  20. BUDGET OF OTHER INSTITUTIONS

  21. POTENTIALS OF MODERN BIOTECHNOLOGIES • Genetic material of one sp. can be inserted into another, crossing natural barriers that were previously impossible. • BETTER CROPS • RESISTANT TO INSECTS • RESISTANT TO DISEASES • EVEN TO NATURAL CALAMITIES LIKE DROUGHT

  22. SOLUTIONS TO THE THREAT OF HUNGER BY HELPING TO INCREASE FOOD PRODUCTION & MALNUTRITION BY • CREATING RICE THAT PROVIDES VITAMIN A & IRON • MAKING AGRICULTURE MORE ENVIRONMENTALLY SUSTAINABLE THROUGH PEST RESISTANT CROPS

  23. BIOPROSPECTING • Research for new chemicals in living things that will have some medical or commercial use • a high risk area for investors but can have massive returns • Of the world's 25 top-selling pharmaceuticals, 10 originally sourced from animals, plants or micro-organisms (in 1995, these accounted for nearly $US14 billion in global sales ) • Pharmaceutical companies and agribusiness use indigenous knowledge as a precursor to screening, and this is happening with little regard for the protection of indigenous intellectual property and with no equitable sharing of profits

  24. CHALLENGES OF MODERN BIOTECHNOLOGY • HEALTH RISKS POISED BY GMO CROPS • POTENTIAL ENVIRONMETAL IMPACTS OF THE RELEASE OF GMOS LEADING TO SERIOUS CONSEQUENCES FOR THE BIODIVERSITY THAT MANY COMMUNITIES RELY ON FOR THEIR FOOD, LIVELIHOODS AND CULTURAL SURVIVAL

  25. BIOTECHNOLOGY & BIOSAFETY POLICIES • Ministry of Environment, Science & Technology had submitted a Biotechnology Policy to the cabinet four years ago for the Govt approval but has not yet been approved. • The Ministry of Forest & Soil Conservation aims to develop & formulate the Biosafety Policy, legal & administrative framework to safeguard the biological diversity, human health and environment from the adverse effects of GMOs & their products in accord with the CBD CPB.

  26. PROBLEMS • LACK OF QUALIFIED MANPOWER & BRAIN DRAIN • LACK OF GOVERNMENT POLICIES, RULES & REGULATIONS • LACK OF ADEQUATE FUNDINGS • LACK OF PROPER INFRASTRUCTURES • FAILURE TO IMPLIMENT RECOMMENDATIONS PROPOSED BY VARIOUS TASK FORCES • LACK OF INVOLVEMENT OF PRIVATE SECTOR AND TEACHING INSTITUTIONS

  27. THE APPLICATION OF GENETIC ENGINEERING TECHNIQUES TO THE DEVELOPMENT OF NEW DRUGS AND VACCINES FOR DEVELOPING COUNTRY LIKE OURS IS AN EXPENSIVE AND LONG TERM INVESTMENT

  28. IMMEDIATE ATTENTION • STRENGTHENING OF EXISTING INFRASTRUCTURES AT DIFFERENT INSTITUTIONS • MANPOWER DEVELOPMENT • RESEARCH & DEVELOPMENT PROJECTS IN COLLABORATION WITH OTHER COUNTRIES

  29. VOTE OF THANKS RECAST & AUDIENCE

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