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What does Lymphoma look like?

OK, lets look at that lumps you called about… WHOA!!!. What does Lymphoma look like?. Stuff to do when you have cancer… #16 Use a tennis ball to see if your oncologist has a sense of humour…. Presenting features of Lymphoma. Lymphadenopathy Hepatosplenomegaly Systemic ‘B’ symptoms Pruritis

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What does Lymphoma look like?

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  1. OK, lets look at that lumps you called about… WHOA!!! What does Lymphoma look like? Stuff to do when you have cancer… #16 Use a tennis ball to see if your oncologist has a sense of humour…

  2. Presenting features of Lymphoma • Lymphadenopathy • Hepatosplenomegaly • Systemic ‘B’ symptoms • Pruritis • Other symptoms like fatigue, anorexia and EtOH induced nodal tenderness • Symptoms due to involvement of other organs

  3. Diagnosis of Lymphoma Hodgkin’s (HL) and NHL rely on a few activities for diagnosis including Full medical history, physical examination, blood work and different imaging studies: • Lymph node biopsy • FBC • ESR • LFT’s • LDH • Uric acid • CXR • CT • Bone marrow aspirate and trephine biopsy • Sometimes PET • NHL may also affect U&E’s due to ureteric obstruction secondary to intra-abdominal/ pelvic lymphadenopathy. NHL is also more likely to produce paraproteins, so an elevated serum Ig level would strengthen diagnosis.

  4. Differential Diagnosis of lymphadenopathy • EBV Infective mononucleosis (risk factor for lymphoma) • Toxoplasmosis • HIV (risk factor for lymphoma) • Cat-scratch • Viral hepatitis • Rubella • CMV • Leukaemia/ Lymphoma • Secondary malignancy

  5. Differential Diagnosis of Splenomegaly • Portal hypertension • Extra-medullary hematopoiesis • Myeloproliferative disease

  6. Epidemiology of lymphoma • In 2001, NHL was the 6th most common cancer in men and 5th most common in women… and 3rd most common in children under 14yrs. • NHL is the 6th most common cause of cancer death with the percentage increasing steadily in both genders – no-one knows why. • At any one time, 30,000 Australians and accounts for 4% of newly diagnosed cancer. • HL is not as common has NHL, with younger people falling victim when compared to NHL.

  7. Epidemiology of lymphoma Incidence of NHL steadily rising whilst HL stays relatively stable.

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