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Colon cancer

Multimodal Treatment of Colorectal Cancer Liver Metastases. Colon cancer. Dr. Efraim Idelevich MD, PhD, Gastrointestinal Oncology Unit Kaplan Medical Center Rehovot Israel. June 2011. COLORECTAL CANCER Worldwide incidence*. Male 39.8 Female 29.0 Male 25.3 Female 18.5 Male 39.5

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Colon cancer

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  1. Multimodal Treatment of Colorectal Cancer Liver Metastases Colon cancer Dr. Efraim Idelevich MD, PhD, Gastrointestinal Oncology Unit Kaplan Medical Center Rehovot Israel June 2011

  2. COLORECTAL CANCERWorldwide incidence* Male 39.8 Female 29.0 Male 25.3 Female 18.5 Male 39.5 Female 24.6 Male 45.8 Female 34.8 Male 5.0 Female 3.8 Male 6.0 Female 4.2 Male 11.2 Female 8.5 Male 8.8 Female 7.9 Male 44.3 Female 32.8 Western Europe Eastern Europe Japan Australia/ New Zealand South CentralAsia Northern Africa Southern Africa Central America Male 44.1 Female 31.0 Israel North America *Incidence per 100,000 population. Parkin DM, et al. CA Cancer J Clin. 1999;49:33-64.

  3. COLORECTAL CANCER1930-1997 Age-adjusted death rate*,male, USA 80 Prostate Lung & Bronchus 70 Colon & Rectum 60 Estimated incidence (% of all cancers in men): Prostate=31%; Lung & Bronchus=14%; Colon and rectum=10% 50 Rate per 100,000 Male Population 40 30 20 10 0 1930 1940 1950 1960 1970 1980 1990 1997 Year *Adjusted to the age distribution of the 1970 census population. Greenlee RT, et al. CA Cancer J Clin. 2001;51:15-36.

  4. COLORECTAL CANCER1930-1997 Age-adjusted death rate*,female, USA 80 Breast Lung & Bronchus Colon & Rectum 70 Estimated 2001 incidence (% of all cancers in women):Breast=31%; Lung=13%;Colon and rectum=11% 60 50 40 Rate per 100,000 Female Population 30 20 10 0 1930 1940 1950 1960 1970 1980 1990 1997 Year *Adjusted to the age distribution of the 1970 census population. Greenlee RT, et al. CA Cancer J Clin. 2001;51:15-36.

  5. COLORECTAL CANCER Disease Stage at Time of Diagnosis Stage I 15% Stage II 20%–30% Stage III 30%–40% Stage IV 20%–25% Hamilton IM, Grem JL. Current Cancer Therapeutics. 3rd ed. 1998;157.

  6. Carcinoma Polyp Metastatic carcinoma EGF Abnormal production of cytokines Angiogenic switch Mutations in growth control genes Mutations in apoptosis control genes

  7. ! Non curable Non curable Stage IV Colon Cancer Group I Group II Group III Group IV Curable Potentially Symptomatic Asymptomatic disease curablenon curablenon curable disease disease disease

  8. EORTC, ASCO 2007

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