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Chapter 16

The Cytoskeleton. Chapter 16. Cell stained with general protein stain shows the cytoskeleton. Filaments are made of small protein subunits. Single protofilament is easy to break. Multiple protofilaments are more stable. Lateral contacts make a strong filament.

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Chapter 16

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  1. The Cytoskeleton Chapter 16

  2. Cell stained with general protein stain shows the cytoskeleton

  3. Filaments are made of small protein subunits

  4. Single protofilament is easy to break

  5. Multiple protofilaments are more stable

  6. Lateral contacts make a strong filament

  7. Cytoskeleton can reshape rapidly

  8. Tubulin heterodimer is the microtubule subunit

  9. Microtubule structure

  10. Microtubules preferentially grow at the plus end

  11. Dynamic instability of microtubules inside a cell

  12. Rapid cytoskeletal changes in fruit fly embryo

  13. DVD Clip 70

  14. Growing and shrinking microtubules

  15. Growing and shrinking microtubules

  16. Growing microtubule has GTP containing tubulin subunits at its end

  17. DVD Clip 71

  18. http://www.studiodaily.com/main/technique/tprojects/6850.htmlhttp://www.studiodaily.com/main/technique/tprojects/6850.html

  19. Structure of actin

  20. Nucleation is the rate limiting step

  21. If actin filaments instead of actin subunits are starting point polymerization starts much faster

  22. Actin binds to many different proteins

  23. Intermediate filaments

  24. Model of intermediate filament structure

  25. Model of intermediate filaments

  26. Intermediate filaments can withstand high levels of deforming force

  27. Keratin filaments in an epithelial cell

  28. Blistering of the skin caused by a mutant keratin gene Normal skin

  29. Blistering of the skin caused by a mutant keratin gene Skin with mutated keratin gene

  30. Blistering of the skin caused by a mutant keratin gene Cells rupture between the nucleus and the hemi- desmosomes

  31. DVD Clip 69

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