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I Can’t Believe It’s Not JEOPARDY!

I Can’t Believe It’s Not JEOPARDY!. Clinical Trials Edition. I Can’t Believe It’s Not JEOPARDY!. 100. What is the purpose of clinical trials?. To ask specific scientific questions to find better ways to prevent, detect, or treat diseases or to improve care for people with diseases.

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I Can’t Believe It’s Not JEOPARDY!

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  1. I Can’t Believe It’s NotJEOPARDY! Clinical Trials Edition

  2. I Can’t Believe It’s NotJEOPARDY!

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  4. What is the purpose of clinical trials? To ask specific scientific questions to find better ways to prevent, detect, or treat diseases or to improve care for people with diseases

  5. I Can’t Believe It’s NotJEOPARDY!

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  7. What is the number one reason cancer patients participate in clinical trials? • The doctor recommended it • They saw an ad in the newspaper • They did research on their own/found it on the internet a. The doctor recommended it

  8. RL Comis, D. Colaizzi and J. D. Miller Cancer clinical trials (CCT) awareness and attitudes in cancer of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Vol 24, No 18S (June 20 Supplement), 2006: 6061

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  11. True or False? Cancer clinical trials are only for people who have no other options left. FALSE There are trials for all kinds of cancers, from the most advanced to the ones found very early.

  12. Fact Clinical trials are not only for those patients with the most advanced disease; many patients get first line treatment through a clinical trial.

  13. At first treatment, in the adjuvant setting, at recurrence… How can we ensure that every patient feels confident to ask, “is there a trial for me?”

  14. I Can’t Believe It’s NotJEOPARDY!

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  16. True or False? New approaches being tested in clinical trials are probably more effective than the current or standard treatment. FALSENew methods may or may not be better than current treatment. A Phase 3 study goal is to determine whether there is a difference.

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  19. True or False? • The reason clinical trials are done is that no one yet knows if a new treatment… • Is safe • Is effective • Will turn out to be better than the approaches currently being used TRUEThese are also the three phases of clinical trials.

  20. There Are 3 Phases of Clinical Trials Phase 1 trials • Is it SAFE? Phase 2 trials • Does it WORK? Phase 3 trials • Is it BETTER than what is used now to treat this cancer?

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  23. True or False? Cancer clinical trials seek to find better types of cancer treatments FALSEThere are many types of cancer clinical trials.

  24. Fact: There are Many Types of Clinical Trials Treatment Even as 1st line Prevention/chemoprevention For primary or secondary cancer Diagnostic • Genetics • Quality-of-life/supportive care • Screening and early detection

  25. Another way to look at it… There are different types of cancer clinical trials • For people who have cancer • Treatment • Genetics • Quality-of-life/supportive care • For people at high risk for getting cancer • Prevention • Genetics • For people being screened for cancer

  26. I Can’t Believe It’s Not JEOPARDY! Round 2

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  29. 3 percent vs. 70 percent What is the percentage of adult cancer patients participating in cancer clinical trials vs. pediatric cancer patients?

  30. More children 0-14 surviving cancer due to CCTs

  31. Very Few People Participate • Less than 3% of all cancer patients receive treatment through a clinical trial (20% eligible) • Participation rate is even lower among people of color, older people, and the medically underserved • who tend to have higher cancer mortality rates than the population as a whole.

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  34. True or False? In randomized clinical trials, patients are assigned to different groups by an objective group of scientists and physicians. FALSE Patients are usually assigned through a computer. Neither the patients nor the doctors can choose the group they want.

  35. In Many Clinical Trials, Participants Are Placed into Different Groups All have an equal chance to be assigned to one of two (or more) groups: • One gets the most widely accepted treatment • The other(s) gets the new treatment being tested, which doctors hope will be better

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  38. FALSE Placebos are never used to substitute for appropriate medical care. True or False? In cancer treatment trials, patients may be given a placebo instead of being appropriately treated for their cancer.

  39. Patients Are Always Treated for Their Cancer • In cancer treatment trials, everyone gets treated • Placebos or “sugar pills” are almost never used instead of appropriate treatment

  40. Trial 123 Treatment being studied Standard

  41. Trial 456 Standard &“Zing,” a treatment being studied Standard & Placebo

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  44. FALSE While it’s not yet known if the new treatment is going to work better than what is currently used, patients can and do benefit from participating. True or False? Patients who join clinical trials today aren’t going to benefit from taking part

  45. Helping Individual Patients Today: A High Quality Treatment Option • Open to many patients, even for first treatment • “The best management for any patient with cancer is in a clinical trial.” (NCCN, 2008) • “Therapies offered through CCTs should ideally be considered the preferred treatment choice for physicians and patients, if they are available” (Institute of Medicine, 2010) Placebos never used instead of appropriate medical treatment

  46. Also important for future patients The only way we will find better ways to treat cancer is through clinical trials… Chance for survival, 1975-1977, all cancers: 50% Chance for survival, 1999-2005, all cancers 68%

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