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図1.ニワトリプロゲステロン(cPR)レセプター遺伝子の構造と遺伝子産物

図1.ニワトリプロゲステロン(cPR)レセプター遺伝子の構造と遺伝子産物. (a)ニワトリプロゲステロンレセプター遺伝子. B1. E1. E2. S. E3. E4. B2. E5. E6. E8. E9. 2. E7. E10. E11. 1. 4. 5. 6. 7. 3. 8. A. B. C. D. E. F. G. 1. 2. (b)遺伝子産物(cPR m RNA). 1. 128. ATG1. ATG2. 410. 495. 546. 786. A/B. C. D. E.

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図1.ニワトリプロゲステロン(cPR)レセプター遺伝子の構造と遺伝子産物

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  1. 図1.ニワトリプロゲステロン(cPR)レセプター遺伝子の構造と遺伝子産物図1.ニワトリプロゲステロン(cPR)レセプター遺伝子の構造と遺伝子産物 (a)ニワトリプロゲステロンレセプター遺伝子 B1 E1 E2 S E3 E4 B2 E5 E6 E8 E9 2 E7 E10 E11 1 4 5 6 7 3 8 A B C D E F G 1 2 (b)遺伝子産物(cPR mRNA) 1 128 ATG1 ATG2 410 495 546 786 A/B C D E 5´UTR 3´UTR cPR0→B型 1 cPR1→B型 367 cPR2→A型 436

  2. 図2.PPARγの構造 A/B C D E/F Wy14,643 Bezafibrate Clofibrate Oleylethanolamide 1 101 166 244 468 α N AF-1 AF-2 C 1 72 137 215 441 GW501516 Prostacyclin β/δ N AF-2 C AF-1 1 108 173 251 475 γ1 N AF-1 AF-2 C 15-deoxy-PGJ2 oxidizedLDL Nitrolinoleic acid Thiazolidinediones 1 138 203 281 505 γ2 N AF-1 AF-2 C DNA-binding Ligand-binding

  3. 表1.PPARのおもな転写共益因子群 コリプレッサー コアクチベーター N-CoR/SMRT CtBP RIP140 Rb COPR LCoR TAZ HDAC1,2,3 SirT1 H3K9-HMT CBP,p300 P160ファミリー  (SRC1/NcoA1)  (GRIP1/TIF2/SRC2)  (SRC3/AIB1) H3R4-HMT  (CARM-1,PRMT-1) PGC-1 PGC-2 PRIP/RAP250 PIMT TRAP220 PRIC285 ERAP140 CITED-2 ARA70 クロマチンリモデリング SWI/SNF WSTF

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