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- DNA

- DNA. Based on. Activity of. Sponsored by. Simulation of Interactions of Radiation with Biological Systems at the Cellular and DNA Level.

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- DNA

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  1. - DNA

  2. Based on Activity of Sponsored by Simulation of Interactions of Radiation with Biological Systems at the Cellular and DNA Level S. Agostinelli, S. Chauvie, N. Crompton, R. Corvó, F. Foppiano, S. Garelli, M. Krengli, F. Marchetto, P. Nieminen, M.G. Pia, V. Rolando, A. Solano, G. Sanguineti

  3. Relevance • The concept of “dose” fails at cellular and DNA scales • It is desirable to gain an understanding to the processes at all levels (macroscopic vs. microscopic+cybernetic) • Quantitative knowledge and strict user requirements scientifically satisfying; may be used as feedback to experimentalists • Potential later connection to other than radiation-induced effects at the cellular and DNA level • Relevance for space: astronaut and airline pilot radiation hazards, biological experiments. Applications in radiotherapy, radiobiology, ...

  4. Anomalous cosmic rays Galactic and extra-galactic cosmic rays Jovian electrons (Neutrinos) Solar X-rays Trapped particles Induced emission Solar flare neutrons and g-rays Solar flare electrons, protons, and heavy ions

  5. The South Atlantic Anomaly(SAA) Courtesy H. Evans (ESA)

  6. Relevance for space: astronaut and aircrew radiation hazards

  7. Programme description • -based “sister” activity to the Geant4 Low-E e.m. Working Group. Follows rigorous software standards • ESA-sponsored + INFN official activity • Simulation of nano-scale effects of radiation at the DNA level • Multiple approaches (RBE parameterisation, detailed biochemical processes, etc.) can be implemented with Geant4 • First year frame: Collection of user requirements & first prototypes • First Milestone: Wide study of the problem area (completed) • Various scientific domains involved: medical, biology, genetics, software engineering, high and low energy physics, space physics

  8. -DNA Collaboration

  9. Collection of User Requirements Biologicalprocesses Physicalprocesses Known, available Process userrequirements Unknown, not available E.g. generation of free radicals in the cell User requirements on geometry and visualisation Chemicalprocesses Courtesy Nature

  10. 5.3 MeV alpha particle in a cylindricalvolume inside cell nucleus. The inner cylinder has a radius of 50 nm. Prototyping

  11. Courtesy A. Brahme (KI) Courtesy A. Brahme (KI)

  12. Future • Completion of Milestone II (rigorous collection of user requirements) to be completed by March 2001 • Completion of the current 1-year programme by June 2001 • Follow-on activity: code implementation based on user requirements and improved prototypes • Structure of the follow-on activity being outlined http://www.ge.infn.it/geant4/dna/

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