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Perspectives Radiation Oncology

Perspectives Radiation Oncology. Improvement of radiation techniques IMRT Protons / Carbon ions Image guided radiotherapy Biological treatment planning Targeted therapies Antibodies / small molecules / siRNA /etc. Tailored therapy Translational research to identify predictive markers.

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Perspectives Radiation Oncology

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  1. Perspectives Radiation Oncology • Improvement of radiation techniques • IMRT • Protons / Carbon ions • Image guided radiotherapy • Biological treatment planning • Targeted therapies • Antibodies / small molecules / siRNA /etc. • Tailored therapy • Translational research to identify predictive markers

  2. IMRT in Head and Neck Cancer

  3. Comparison of dose distributions: Photons vs. Protons 1-portal technique 4 -portal technique 100 80 60 40 20 0 100 80 60 40 20 0 TARGET % Dose % Dose TRAGET 0 10 20 30 40 0 10 20 30 40 depth [cm] depth [cm] Photons Photons Protons (multiple Bragg Peaks) Protons (ein Bragg Peak) Protons (multiple Bragg Peaks) Sum Photons / Protons

  4. Comparison of dose distributions: Photons vs. Protons IMRT Protons Miralbell et al. 2000

  5. PET IUDR Proliferation 70 Gy PTV Biologic Target Vol. (BTV) CTV 77 Gy PET F-Miso / FAZA Hypoxia 84 Gy MR / MRS Cholin / Citrat Tumorlast Biologic treatment planning Biologic treatment planning based on PET-CT and IMRT

  6. Perspectives Radiation Oncology • Improvement of radiation techniques • IMRT • Protons / Carbon ions • Image guided radiotherapy • Biological treatment planning • Targeted therapies • Antibodies / small molecules / siRNA /etc. • Tailored therapy • Translational research to identify predictive markers

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