Enzymes and drugs

2. Enzymes and drugs P450 enzymes P450 enzymes P450 enzymes Active Drug Enzyme Inactive drug P450 enzymes breakdown/metabolize active drug

3. P450 enzymes P450 enzymes P450 enzymes Inhibitors slow p450 Active Drug is increased • Inhibitors slow the enzyme • Increase drug concentration

4. Enzymes and drugsINDUCERS - ↑↑↑↑ metabolism Active Drug is decreased Inducers Speed p450 Inducers increased metabolism Reduce drug concentration

5. Enzymes and drugsInhibit0rs- ↓↓↓ metabolism Inducers increased the enzyme Reduce drug concentration