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Emotional Memory ( The Prefrontal Cortex) & Phineas Gage

Emotional Memory ( The Prefrontal Cortex) & Phineas Gage . B9902052 陳 黎 B9902068 曾資斌. A Gruesome but True Story. Phineas P. Gage (1823 –1860) construction foreman left frontal lobe destroyed effects  ? "no longer Gage". 左前額葉與生理機能無關. 生理機能正常. 左前額葉皮質嚴重損壞.

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Emotional Memory ( The Prefrontal Cortex) & Phineas Gage

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  1. Emotional Memory ( The Prefrontal Cortex) & Phineas Gage B9902052 陳 黎 B9902068 曾資斌

  2. A Gruesome but True Story • Phineas P. Gage (1823 –1860) • construction foreman • left frontal lobe destroyed • effects  ? • "no longer Gage".

  3. 左前額葉與生理機能無關 生理機能正常 左前額葉皮質嚴重損壞 左前額葉與情緒表現相關 情緒表現異常 How? The Limbic System • Before&After

  4. Take a Closer Look…… • Before • After • Why?? Prefrontal cortex damaged Emotionally detached impatient erratic

  5. The Lymbic System

  6. Prefrontal cortex(PFC) • Frontal lobe • granular • electrical stimulation Motor cortex Premotor area Prefrontal cortex • evoke movements

  7. Function • Importance? • CEO of the brain • Jiminy cricket “It is the tiny voice help you decide what is right and wrong.”

  8. When PFC goes wrong… • 運作過度…… • 活動低落…… (lack of dopamine)

  9. What happened to Gage? • Destroyed • Not destroyed

  10. PFC & ADHD • 意力不足過動障礙症(過動症) • Attention Deficit Hyperactivity Disorder • Why? • Dopamine • dopadecarboxylase 多巴脫羧酵素

  11. Lobotomy 前額葉切離手術 • Egas Moniz, 1935 • Schizophrenia, clinical depression • Connections to PFC

  12. Reference • PHINEASGAGE:AGruesome but True Story About Brain Science, by John Fleischman, 2002 • Making A Good Brain Great, by Daniel G. Amen, 2007 • 認識你的頭腦, 洪祖培教授、邱浩彰醫師著 • http://en.wikipedia.org/wiki/Prefrontal_cortex • http://en.wikipedia.org/wiki/Lobotomy • http://www.dls.ym.edu.tw/neuroscience/adhd_c.html • http://sanitaryplaza.blogspot.com/2007/07/lobotomy.html

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