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Kate Li Chemical Engineering & Biochemistry

Kate Li Chemical Engineering & Biochemistry. Characterization of Diffusion from Mesoporous Silica Nanoparticles for Potential Drug-Delivery Applications. Mesoporous Silica Nanoparticles.

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Kate Li Chemical Engineering & Biochemistry

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  1. Kate Li Chemical Engineering & Biochemistry Characterization of Diffusion from Mesoporous Silica Nanoparticles for Potential Drug-Delivery Applications

  2. Mesoporous Silica Nanoparticles Figure 1: Diagram of different ways to functionalize a mesoporous silica nanoparticle – external and pore surface functionalization (Colila et. al 2013).

  3. Why MSNPs? • Tunable drug delivery • Antibodies for site specificity • Within threshold size for cellular uptake (D ~100 nm) • Controlled and sustained release • Applications: chemo toxic drugs, nonpolar with low bioactivity in the body due to poor solubility • Silica is bioinert Glass cardiovascular system sculpture by Gary Farlow

  4. Modified Stӧber Process Reagents: • Cetyltetra-ammoniumbutylate (CTAB) • Tetraethyl orthosilicate (TEOS) • NaOH • EtOH • Water

  5. Forming a Liquid Crystal

  6. Experimental Procedure • Procedure: • Add .375 g of CTAB, .4375 mL 2.0 M NaOH and 30 mL dI H2O to roundbottom flask with magnetic stir bar and heat to 80⁰C for 30 minutes. • To clear solution, add 2.48 mL TEOS via rapid injection. • White precipitate will be observed after 1-2 minutes of stirring. • Maintain reaction temperature at 80⁰C for 2 hrs. • Isolate product via ethanol wash and centrifugation/sonication cycles of 10 minutes each, four times. Dilute and suspend in ethanol. Materials: - TEOS (tetra ethyl orthosilicate) - EtOH (ethanol) - CTAB (cetyltrimethylammonium bromide) - NaOH (sodium hydroxide) - dI H2O(deionized water) Characterization: - N2 absorption - SEM, TEM, SAXRD

  7. Experimental Observations

  8. Results

  9. Results

  10. Theoretical Modeling

  11. Further research • Further research on the parameters of the Modified Stӧber Process • Attempting functionalization of surface and pores • Generate diffusion data

  12. Thank you NASA Space Grant UA Honors College – Alumni Travel Grants Dr. Anthony Muscat Questions? NASA Space Grant Consortium

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