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ONTARGET

ONTARGET. Telmisartan (16.7%) noninferior; combination (16.3%) not superior to ramipril (16.5%) for primary endpoint (CV death, MI, stroke, heart failure) Greater incidence of hypotension in combination (4.8%) and telmisartan (2.7%) groups, compared with ramipril group (1.7%) (p < 0.001).

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ONTARGET

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  1. ONTARGET Telmisartan (16.7%) noninferior; combination (16.3%) not superior to ramipril (16.5%) for primary endpoint (CV death, MI, stroke, heart failure) Greater incidence of hypotension in combination (4.8%) and telmisartan (2.7%) groups, compared with ramipril group (1.7%) (p < 0.001) (p < 0.004*) (p = ns) Trial design:Patients at high risk for cardiovascular events, but without heart failure, were randomized to telmisartan, ramipril, or the combination. Patients were followed for a median of 56 months. Results 16.7 16.3 16.5 11.6 12.5 11.8 15 20 % 10 10 % 5 Conclusions • Either telmisartan or ramipril, but not both, can be used in hypertensive patients at high risk for cardiovascular events • Side effects greater with combination therapy 0 0 Primary endpoint Mortality Telmisartan (n = 8,542) Combination (n = 8,502) Ramipril (n = 8,576) * Telmisartan vs. ramipril for noninferiority The ONTARGET investigators. N Engl J Med 2008;358:1547-59

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