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Complex Spine surgery in the Elderly Patient: When to Say No!. Colin b. harris, md Assistant professor Spine division Rutgers – new jersey medical school. DISCLOSURES. CONSULTING/TEACHING GLOBUS, INC. Why are we talking about this today?. Adult spinal deformity Heterogeneous Complex
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Complex Spine surgery in the Elderly Patient: When to Say No! Colin b. harris, md Assistant professor Spine division Rutgers – new jersey medical school
DISCLOSURES • CONSULTING/TEACHING • GLOBUS, INC
Why are we talking about this today? • Adult spinal deformity • Heterogeneous • Complex • Often requires surgery • Surgery improves outcomes* • HRQoL years • However.. Smith, Lafage, Shaffrey et al. Neurosurgery 2016.
The facts • Adult spinal deformity surgery OFTEN requires: • Long dissections • Long-segment spinal fusion • Osteotomies • 6-8 hr + surgery • Multiple transfusion PRBC • Extended hospitalization Cho, Bridwell, Lenke. Spine 2010 Yagi, Rahm, Gaines. Spine 2014 DeWald, Stanley. Spine 2006
What are the risks? • Neurologic deficit • Implant related complications • SSI • Pneumonia/UTI • Delirium • Renal failure • Ileus • Failure to thrive
What are the risks? • Neurologic deficit • Implant related complications • SSI • Pneumonia/UTI • Delirium • Renal failure • Ileus • Failure to thrive 30-60%
What are the risks? New neurologic deficit 8.7% Mean EBL 2120 mL Mean OR time 7 hours 50.8% medical complications • Neurologic deficit • Implant related complications • SSI • Pneumonia/UTI • Delirium • Renal failure • Ileus • Failure to thrive 30-60% Kelly M, Lenke L, Shaffrey C, et al. Neurosurg Focus 2014
Minimizing the risks • PATIENT SELECTION • Medical optimization • Meticulous preoperative planning
Minimizing the risks • Medical optimization • Cardiology • Pulmonology • Every patient needs BMD evaluation • Nutrition status* • Albumin >3.5 g/dL • Total lymphocyte count >1500 cells/mm3 • Transferrin >200mg/dL • Zinc >95 mg/dL Gherini et al CORR 1993;293:188-95 Greene et al J Arthroplasty 1991;4:321-5
Obesity • Defined as BMI>30 (morbid obesity = BMI>40) • Shown to result in increased risk of: • Medical complications • Wound complications • Higher cost per stay • Nutrition consult, involve PCP • Consider bariatric referral BMI>30 Puvanesarajah V, Werner B, Cancienne J, et al. Spine 42(2): 122-7, 2016
Database review of control, obese (BMI >30), morbidly obese (BMI>40) • Obese/morbidly obese with higher rates of wound infection (3.5X), major medical complication (OR 1.79), respiratory failure, renal failure • Obese / MO with higher 30-day re-admission (OR 1.62) and LOS • In-hospital costs increased by $8,000 • Conclusion: Careful selection and counseling needed prior to surgery
Database review of 156,517 patients undergoing elective lumbar fusion • Normal body weight (BMI <25) vs morbidly obese (BMI>40) vs bariatric surgery (BS) + obese • Rates of UTI, respiratory failure, ARF, infection, medical complications lower in BS vs morbidly obese group (p<0.05) • BS group = normal body weight group in medical complications • BS higher infection, reoperation and readmission rates • Conclusions: Consider referral for BS prior to elective spine fusion
Osteoporosis • Consider teriparatide (Forteo) x9-12 months prior to surgery • Must coordinate with Endocrinology • Bony union rate 82%* • Decreased incidence pedicle screw loosening • =/- Follow-up preop DEXA (controversial) • Ohtori S, Inoue G, Orita S, et al. Spine 2012;37:E1464-8.* • Ohtori S, Inoue G, Orita S, et al. Spine 2013;38:E487-92.
How about ASA class? • ASA class III/IV = significant risk factor for: • Mortality • Reoperation within 30 days • LOS • Need for transfusion • Postoperative sepsis • Must counsel regarding increased complications & potential poor outcome Somani S, Capua J, Kim J, et al. Global Spine J 7(8):719-26, 2017.
Preoperative planning • Consider digital planning program (Surgimap, Nemaris, Inc) • Must assess alignment on full length scoliosis radiographs C7 plumb line SVA CSVL
Goals of Surgery • Decompress neural elements • Obtain solid fusion • Restore spinal balance • Avoid complications Glassman S, Bridwell K, Dimar J et al. Spine 2005 Schwab F, Ungar B, Blondel B, et al. Spine 2012
Goals of Surgery • PI – LL <11º • PT < 22º • SVA <5cm Sagittal plane drives disability Coronal plane not so much Schwab F, Ungar B, Blondel B, et al. Spine 2012
SVA +7cm Planned correction SVA 0
Preop Planning SVA +12cm PI – LL = 44
Preop Planning C7 plumb SVA +12cm PI – LL = 44 12 cm
Executing the plan • Consider staging if >6hrs, EBL>1L • Stage 1: Exposure, remove prior implants, instrument • Stage 2: Perform decompression, osteotomies, place graft / rods Lin J, Lenke L, Shillingford J, et al. Spine Deform 2018;6(2):189-94
Executing the plan • Consider staging if >6hrs, EBL>1L • Stage 1: Exposure, remove prior implants, instrument • Stage 2: Perform decompression, osteotomies, place graft / rods • 2-surgeon approach can save time and EBL Lin J, Lenke L, Shillingford J, et al. Spine Deform 2018;6(2):189-94
Executing the plan • Consider staging if >6hrs, EBL>1L • Stage 1: Exposure, remove prior implants, instrument • Stage 2: Perform decompression, osteotomies, place graft / rods • 2-surgeon approach can save time and EBL • Consider O-arm, Stealth, robotics for complex deformities • Cell Saver, 4-6 units T&C, neuromonitoring Lin J, Lenke L, Shillingford J, et al. Spine Deform 2018;6(2):189-94
Executing the plan • Consider staging if >6hrs, EBL>1L • Stage 1: Exposure, remove prior implants, instrument • Stage 2: Perform decompression, osteotomies, place graft / rods • 2-surgeon approach can save time and EBL • Consider O-arm, Stealth, robotics for complex deformities • Cell Saver, 4-6 units T&C, neuromonitoring • Consider tranexamic acid 50mg/k loading dose -> 5mg/kg/hr until closure Lin J, Lenke L, Shillingford J, et al. Spine Deform 2018;6(2):189-94
Executing the plan • Consider BMP, ICBG for long fusions • Meticulous layered closure over drains, incisional wound VAC • Plastic Surgery paraspinal flaps helpful if wound under tension • Observe closely for new neuro deficits in first 24 hrs postop
Complications • EARLY • Paralysis, nerve root injury (most common) • Infection, wound healing problems • Blood loss requiring transfusion • CSF leak • LATE • Non-union (leading to rod or screw fracture) • Adjacent segment “PJK” (Proximal, Distal) >50%!
WHEN TO SAY NO! • Smokers • Chronic opioid use • Poorly controlled DM (HgbA1C >7) • Osteoporosis – use caution • T-score <2.5 SD below mean • Obesity (BMI > 40), Beware BMI > 35 • Chronic steroid use • Moderate or Severe COPD De la Garza Ramos R, Nakhla J, Echt M, et al. Global Spine J 2018
Single surgeon early and late outcomes with posterior VCR • N=34 consecutive patients • Overall 58% experienced complications (13 vs 3) • Results: • Group 1 (inexperienced): 492 min, EBL 1294, 22.8 day LOS • Group 2 (Experienced): 350 min, EBL 974, 13.4 day LOS • CUSUM: complications may reduce after 17 cases and stabilize by 29 cases • Conclusion: PVCR is safer when performed by experienced surgeon
Bottom Line • Adult deformity correction can improve QOL but fraught with dangers • Success depends on many factors that must align: • Meticulous planning & understanding of sagittal parameters • Medical/nutrition/osteoporosis optimization • Must know when to say no…
If in doubt… • Refer to a high volume tertiary center • Get a second opinion!