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Leu427

AfPiwi. Leu427. scissile phosphate target strand. Glu264. catalytic aspartates. PfAgo.

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Leu427

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  1. AfPiwi Leu427 scissile phosphate target strand Glu264 catalytic aspartates PfAgo Supplementary Figure 3. Details of the putative slicer catalytic site. The RNase H domains of AfPiwi (orange) and PfAgo11 (violet) are superimposed, and the putative magnesium dependent RNase H-like catalytic Asps present in PfAgo are displayed. An invariant Glu (Glu 264 in AfPiwi) which completes the DDE triad is displayed in both proteins. The catalytic Asps approach the scissile phosphate within 10-11 Å. Residue numbers are for AfPiwi. The guide strand is omitted for clarity.

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