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Neoplasia VI

Neoplasia VI. DR OSAMA I NASSIF MD,FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY KAUH. Etiology of cancer. Chemical carcinogens. Radiation carcinogenesis. Viral oncogenesis. Biology of tumor growth. Kinetics of tumor cell growth. Tumor angiogenesis.

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Neoplasia VI

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  1. Neoplasia VI DR OSAMA I NASSIF MD,FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY KAUH

  2. Etiology of cancer. • Chemical carcinogens. • Radiation carcinogenesis. • Viral oncogenesis.

  3. Biology of tumor growth. • Kinetics of tumor cell growth. • Tumor angiogenesis. • Tumor progression and heterogeneity. • Tumor invasion and spread.

  4. Kinetics Of Tumor Cell Growth • Doubling time : equal or more than that of normal cells. • Growth fraction : cells in replicative pool , rarely >20%. • Production vz loss :

  5. Tumor Angiogenesis • Tumor-associated angiogenic factors : -bFGF , VEGF……etc. • Macrophage derived growth factors: -TNF-α. • Weak angiogenic inhibitors: -Angiostatin , thrombospondin ( p53 upregulated) .

  6. Kinetics Of Tumor Cell Growth Clinical implications: 1- cancer therapey: Targeting cycling cells. Effect of radiation & debulking. 2- latent period of tumors : Months to years.

  7. Tumor Progression and Heterogeneity.

  8. Tumor Invasion and Spread. • Methods of spread : - Direct. -Through blood vessels. -Through lymph vessels.

  9. Etiology of Cancer. • Chemical carcinogens. • Radiation carcinogenesis. • Viral oncogenesis.

  10. Chemical Carcinogens.

  11. Chemical Carcinogens.

  12. Chemical Carcinogens

  13. Chemical Carcinogens

  14. Chemical Carcinogens

  15. Chemical Carcinogens

  16. Chemical Carcinogens

  17. Chemotherapy Induced Malignancies

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