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48 hr

Pro-MMP-10 (ng/mL). 48 hr. 96 hr. Supplemental Figure 6 R3Mab reduces serum levels of human pro-MMP-10 in mice bearing RT112 xenograft tumors in a dose- and time-dependent manner.

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48 hr

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  1. Pro-MMP-10 (ng/mL) 48 hr 96 hr Supplemental Figure 6 R3Mab reduces serum levels of human pro-MMP-10 in mice bearing RT112 xenograft tumors in a dose- and time-dependent manner. Mice with pre-established RT112 tumors were grouped randomly into cohorts of 5 for treatment with either a control antibody (0) or R3Mab (3 or 30 mg/kg). Serum was collected at 48 hr or 96 hr post-treatment, and human pro-MMP-10 level was measured by Elisa.

  2. A B Supplemental Figure 7 R3Mab reduces serum levels of human MMP-1 and pro-MMP-10 in mice bearing UMUC-14 xenograft tumors. Mice with pre-established UMUC-14 tumors were grouped randomly into cohorts of 10 and treated with a control antibody (Ctrl Ab) or R3Mab (30 mg/kg). Serum was collected at indicated time points, and subject to ELISA for total human MMP-1 (A) and pro-MMP-10 (B).

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