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“Molecular Workbenches” Protein structure

“Molecular Workbenches” Protein structure. Life is a system of elements that can replicate the entire set of elements from rudimentary parts to form new copies of the whole system. Elements: Are large, macro-molecules, such as DNA, RNA and proteins, with 1000’s of covalently linked atoms.

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“Molecular Workbenches” Protein structure

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  1. “Molecular Workbenches” Protein structure

  2. Life is a system of elements that can replicate the entire set of elements from rudimentary parts to form new copies of the whole system.

  3. Elements: Are large, macro-molecules, such as DNA, RNA and proteins, with 1000’s of covalently linked atoms. Rudimentary Parts: Are the building blocks for the elements. DNA and RNA are made from nucleic acids; proteins are made from amino acids. These are small molecules held together by covalent bonds.

  4. Two Types of Atomic Interaction: Covalent Bonds (make molecules) Non-covalent Bonds (make molecules come alive)

  5. Two Types of Covalent Bond: Non-polar (electronically balanced) Polar (electronically unbalanced)

  6. Molecules “see” each other by non-covalent interactions of their electron shells.

  7. 4 Types of Non-covalent Bonds: (1) van der Waals (2) hydrogen bonds (3) ionic (4) hydrophobic effect

  8. Covalent and non-covalent Chemical bonds:

  9. Living things have very high information content.

  10. Proteins are amino acid polymers.

  11. Amino Acids

  12. Building Molecules: The Condensation Reaction

  13. Four levels of protein Structure: 1°-aa sequence 2°-local folds/structure 3°-structure of polypeptide 4°-polypeptide interactions

  14. Two common folds: a-helix b-sheet

  15. cytochrome b antibody NAD-binding

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