The 10 Most Advanced IVF and Fertility Centers 2018

1. www.insightscare.com October2018 The10 MostAdvanced IVFAND FERTILITY Centres2018 KishoreKumar Founder &Chairman Cloudnine DedicatedtotheHolisticWell-being ofaMotherandHerBaby

4. ave you ever imagined that you and your partner visitinga Fromthe Editor maternity and fertility clinic and while you aresipping descriptions of embryos? Yes, that’s right! There are hundreds of descriptions of the embryos that you can pick from, all made byIn- vitro Fertilization (IVF); from you and your partner’s egg and sperm. Thus, handing it over to you, will you choose it? Choosing the eye color, height, complexion, physic, or immunity of your baby could be a possibility in the nearfuture. Although this idea of cherry-picking your baby’s phenotype and talents fills most of us with a sense of dismay. Yet, some are overpowering the taboo in a proposition to create ‘the perfectchild’ or ‘a designer baby’. If there’s any kind of future for ‘designer babies’, it might look somewhat likethis. Hyour coffee you are offered a menu card, containing DNA editing could one day develop into an option for parents wanting to ‘alter the genetic characteristics of their child.’ Well this day is not far now. The advancements in Genetics, Biotechnology, and Genetic Engineering have opened the doors wide open to manipulate and conceive customized babies. While technologies like CRISPR Cas9 or RNA silencing combinedwith In-vitro Fertilization could play an enormous role in curing susceptibilities to cancers and dementia, or devastating genetic illnesses, scientists have not ruled out the cosmetic uses aswell. ‘Designer Babies’ Future of Parenthood? The ethical repercussions of manipulating human embryos are huge. Many scientists have raised queries over thesetechnologies and they have been termed as a ‘slippery slope’ towards the alteration in human embryos. At present, researchers are only permitted to genetically edit human embryos for 14 days for research purposes, after which they must be destroyed. And it is illegal to implant them into awomb. Due to the high possibility of misuse of these technologies and the interference it will create in the natural reproductive process, ethics have not yet legalized the full-fledged study of these technologies on human embryos. CRISPR Cas9, a genetic editing technique, which acts like a molecular scissors to snip away bad DNA and interchange it with healthy code, is reported to be most sought out procedure that may pose as a prospective tool. However, there have been reports recently that have suggested that the technique might cause wide-ranging mutations in the DNA away from the anticipated site. The researchers have warned the scientific community that this may lead to important genes being switchedon or off, which may cause devastatingconditions. On a irrefutable note, it is safe to say that although these technologies will pose as promising prospect for parents whowish to customize the genotype and phenotype of their babies; the ethical and scientific concerns need to be addressed with utter scrutiny to make ‘designer babies’ areality. ane Sayali SayaliRane

5. Editor-in-Chief Pooja M. Bansal Managing Editor Devasish Kanojiya Executive Editor SayaliRane Contributors Aishwarya Nawandhar, Urvasi,Shweta Visualiser DavidKing Art & Design Director AmolKamble Associate Designer PriyankaRajage Co-designer RahulKavanekar Art & Picture Editor PaulBelin JayantKhanna Business Development Manager AkanshaGarewal Marketing Manager DhruvApte SalesExecutives Karishma M.Attar Technical Head SwapnilPatil Technical Specialist Amar, Vivek,Pratiksha Digital Marketing Manager MarryD’Souza SME-SMOExecutives Prashant Chevale, UmaDhenge Circulation Manager Robert, Tanaji Database Management Stella Andrew Technology Consultant DavidStokes sales@insightscare.com October,2018 CorporateOfces: Insights Success Media and Technology Pvt. Ltd. Ofce No. 510, 513, 5th Floor, RainbowPlaza, Shivar Chowk,Pimple Saudagar, Pune, Maharashtra 411017 Phone - India: 7410033802,74100058552 Email: info@insightscare.com For Subscription:www.insightscare.com Insights Success Media Tech LLC 555 Metro Place North, Suite 100, Dublin, OH 43017, United States Phone -(614)-602-1754 Email:info@insightscare.com For Subscription:www.insightscare.com Copyright © 2018 Insights Success, All rights reserved. The content and images used in this magazine should not be reproduced or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission fromInsights Success. Reprint rights remain solely withInsights Success.

6. CXOStandpoint CoverStory 22 38 10 Cloudnine 50 Dedicated to the Holistic Well-being of a Mother and HerBaby Articles UTI inGynaecology Urinary Problems in Gynaecology 22 28 40 PregnancyNutrition Nutritional Desideratum duringPregnancy Advances inIVF New-age Techniques that can Prevent Life-Threatening Diseases amongInfants Resilience & Courage How to Become More Courageous and Resilient in ourlife? 38 RisingInfertility Why is infertility so common today? 50

7. 20 Interview withInsightsCare Contents 18 OoWomaniya Revolutionizing&Offering aComprehensiveHealth Solutions forWomen 26 BarmadeHospital Offering Distinctive Services to Realise the Dream ofMotherhood 20 32 International FertilityCentre A Revered Destination where Lost Hope turns into JoyfulBlessing 26 44 KGN Test-Tube Baby Hospital & ResearchCentre Cherishing Motherhood at itsBest 32 44 Mannat Fertility-IVFCentre A Blessing inDisguise 48 48 MedAnsh A Preferred Destination forIVF Pravi IVF & FertilityCenter Pioneer in Introducing Advanced, Transparent and Ethical Practices inIVF 54 54

8. In-vitro Fertilization A Need of theHour 1 MostAdvanced The IVF &FERTILITY Centres2018 S(IVF) market sizeis anticipated to propagate at a CAGR of around 10%. It is already a USD15 billion dollar ince the first IVF birth of Louise Joy Brown, in the 1978, the industry has seen tremendousadvancements. Both technology and healthcare have always advanced simultaneously. The worldwide in-vitrofertilization industry. The increased cases of infertility and development of advanced technologies, like lens-less imaging ofthe sperms, are expected to drive the market in the impendingyears. The busy schedules and careers have taken a toll on our reproductive health. A recent report has suggested that 25% of the couples have more than one factor that leads towards infertility. Immune infertility, sexually transmitted infections, genetic disorders, hormone imbalance, and mainly lifestyle changes have influenced the reproductive health of both males and females. The change in the average age of men and women getting married and having their first baby has increased, due to educational and career priorities. This tendency has amplified the number of women opting for the IVF treatment. Besides, to emphasize on their jobs, a lot of women freeze their eggs to have a child ata later stage inlife. The government has subsidized egg/sperm freezing, to bring down the probabilities of multiple pregnancies. Technological developments that aid in pre-identification of the genetic illnesses, and numerous other industrial upheavals are expected to boom the IVF market growth. With the growing number of patients deciding on IVF and gamete freezing, the demand is anticipated to witness growth. With the need for high standards of IVF treatment,we bring the “The 10 Most Advanced IVF and Fertility Centers 2018.” These fertility clinics are providing contemporary paraphernalia to meet all the demands the IVF and Fertility verticalposes. On the cover we have Cloudnine Hospital; it is India’s premier destination for comprehensive woman & child healthcare. We have also incorporated some clinics that are creating milestones, with their state-of the-art infrastructure and services, to combat infertility. KGN Test-Tube Baby Hospital & Research Centre provides comprehensive information and alternative options for making infertility affordable; Barmade Hospital provides a holistic solution to all infertility problems, with its state-of-the-art infrastructure and noble vision to fulfil the dreams of motherhood; International Fertility Centre gives hope to those who are left in despair due to their infertility and brings happiness to their gloomy faces with its state-of-the-art fertility treatment; Pravi IVF & Fertility Center is gaining popularity among consumers due to its advanced IVF treatment; Mannat Fertility-IVF Centre is a fertility solution centre, dedicated to the holistic wellbeing of its patients; MedAnsh Multispeciality Hospital is focused on healthcare needs of women, and provides customized ART treatment at affordable prices in a comfortable atmosphere; Xenith Advanced Fertility Center, Nova IVI Fertility, and ManipalFertility. We also bring an interesting view into OoWomaniya, a platform that has revolutionized the way women access and retrieve healthcareinformation. Apart from this we have also included some articles written by Experts, who have contributed to the IVF and Fertility sector. We have also included some articles and facts that might intrigue you; these have been penned down by our in- house editorialteam. So flip through the pages to embark on journey of happy and healthy maternity!

10. CoverStory Cloudnine DedicatedtotheHolisticWell-beingofaMother and HerBaby Ithing is certain —your life will never be the same”. Bringing a child to life is no less n a book called ‘Eating for Pregnancy’, Catherine Jones said, “Whetheryour pregnancy was meticulously planned, medically coaxed, or happened by surprise,one than a miracle, especially for a parent. So many couples dream of parenthood everyday. Wistfully, infertility affects approximately one out of ten people, round the world. But today, with the development of various technologies and numerous inventions, it is possible to overcome this hurdle to attain parenthood without aworry. One such prominent hospital chain, Cloudnine Group of Hospitals, has been creating the miracle of childbirth every day. Incepted in 2007, it is India’s premier destination for comprehensive woman & child healthcare. Cloudnine believes that every story is unique and it crafts a distinctive fertility plan for every couple trying to conceive, investing much time and thought into every family that it creates. The success story of the hospital ismade up of thousands of little ones, each belonging to a family born atCloudnine. The organisation envisions to effectively bridge the gap between Indian and international standards through a combination of clinical excellence, comprehensive care, and an atmosphere of celebration, to ensure world-class standards. Its fertility facilities are aligned to an international gold standard, carefully enfolded in superlative medical expertise and state-of-the-art technology, and layered with thought and care. With a team composed of veteran medical specialists sourced from across the globe, it is not a surprise that Cloudnine’s success rates are some of the best in India, offering every couple the hope of ababy.

11. KishoreKumar Founder &Chairman

12. “ At Cloudnine, we believe in breathingmagic and memories into pregnancy andparenthood “ youngest and highest qualified neonatologists in the world. Amidsthis many awards and accreditations is the honour of being felicitated by former US President, Bill Clinton, for his exceptional achievements in the field ofneonatology. Preimplantation GeneticScreening (PGD) and Time-lapse Embryo Monitoring(TLM). The Ideal Leader ofCloudnine Dr. R. Kishore Kumar, Founder and Chairman of Cloudnine Group of Hospitals, established the hospital chain in 2007 to realize his vision of high quality healthcare in India, at par with international standards. During his training, he saw the number of deaths due to lack of qualitative medical care in India, but hardly any during his 16-year-tenureabroad. Hence, he had this dream ofproviding similar care inIndia. Best-in-Class Services Today, Cloudnine’s world-class services envelop a broad spectrum of medical specialties, including maternity, gynaecology, paediatrics, neonatology, fertility, and stem cell banking. Cloudnine Fertility is stitched from a versatile fabric that enwraps a veritable legion of fertility treatments. Its made-to-measure solutions encapsulate the following treatments: Ovulation Induction and Cycle Monitoring, Intrauterine Insemination (IUI), In Vitro Fertilization (IVF), Intra-cytoplasmic Sperm Injection (ICSI), Blastocyst Transfer, Frozen Embryo Transfer (FET), Hysterosalpingogram (HSG) andTubal Evaluation, Hysteroscopy and Laparoscopy Surgeries, Doppler Tests & Urological Procedures, Surgical Sperm Retrieval - TESA, MESA,PISA, Journey through theYears Started with a flagship centre at J P Nagar in 2009, Cloudnine established its fertility services at Malleshwaram branch in three years. In 2014, it completed more than 2500 IVFcycles. Expanding its facilities further, the organisation started fertility services at Cloudnine hospitals in Chennai, Gurugram, Pune, and Mumbai by 2015. Here, it introduces latest technologies like Laser-assisted Hatching (LAH) and DNA Fragmentation Index (DFI). A year after that, it launched the Cloudnine Fertility facility at Old Airport Road, Bengaluru. Later, the hospital chain adopted advanced technologieslike Dr. Kishore is an internationally acclaimed neonatologist who has worked in four continents over the course of his career. He completed his MBBS, DCH, MD from India, DCH& MRCP from London & FRCPCHfrom UK; MRCPI and FRCPI from Ireland. Additionally, he also holds Fellowship in Advanced Neonatal ICU from Melbourne with an FRACP from Sydney, Australia. At the beginning of his career, he was amongst one ofthe

13. 1 MostAdvanced The IVF &FERTILITY Centres2018 Micro TESE, Cryopreservation of Embryos, Vitrification of Eggs, Endometrial Receptivity Analysis (ERA), Time Lapse Embryo Monitoring, Laser Assisted Hatching (LAH), Preimplantation Genetic Screening (PGS), DNAFragmentation Index of Sperm (DFI), Oocyte Donation, Sperm Donation, Surrogacy and Gestational Surrogacy, and Counselling. DistinguishingFeatures Cloudnine is one of the best in theIVF and fertility industry of India. The elements that help it outshine the counterpartsare: Seasoned Super-specialists: Team Cloudnine of seasoned fertilitysuper- specialists is underpinned by superior technological infrastructure and cutting-edge medical procedures. Its medical team is geared towards male and female fertility in equal measure, ensuring a holistic treatment planand higher success rates for a couple seekinghelp. Advanced Technologies: AtCloudnine, they strive to stay ahead of the curve, by constantly updating our technological repertoire. Their treatment portfolio includes modern technologies such as Time Lapse Embryo Monitoring, Vitrification, Preimplantation Genetic Screening (PGS), DNA fragmentation index (DFI), laser assisted hatching (LAH), and micro testicular sperm extraction (micro TESE). State-of-the-Art Infrastructure: Cloudnine’s gold-standard infrastructure is a true testament to the thought and care that goes intocreating a fertility protocol. Its fertility ecosystem is composed of dedicated operating theatres andtreatment

14. “ Weprovide world-class medicalexpertise, state-of-the-art facilities,and a spacelled with love andlaughter “ laboratories, equipped with air filters and environmental control features. Every Cloudnine Fertility unit also hosts an exclusive Andrology Labthat deals with diagnosing male fertility issues. personal, ethical, transparent, and confidential, ensuring the people seeking help are enveloped in privacy, all the way through. Every treatment cycle also includes a sequence of counselling sessions to prepare them for the road ahead. Cloudnine’s success rates are reflections of the depth of detail involved in every treatmentplan. the world. Babies conceived through IVF are at a higher risk of being born premature and a state-of-the-art NICU facility can offer a supportive environment armed with necessary resources for preemies to thrive in. Its GE Giraffe incubators and medical infrastructure form an uplifting ecosystem that is specialized incaring for babies as premature as 24weeks. Consistency in Processes: The revolutionary fertility treatments offered at Cloudnine are the best of their kind in India today. The hospital pays close attention to training and its processes, protocols, and successrates are consistent acrossIndia. State-of-the-Art NICU Facilities: The seasoned neonatal team at Cloudnineis experienced at handling high-risk preterm deliveries. Its NICU has been certified as Level-3 by the National Neonatology Forum and features the most advanced neonatal equipmentin Measures to Tackle Challenges in the Industry Cloudnine has been pro-active and providing the information on leaflets, blogs, and websites about itstreatment options to the clients – beingvery Guest Experience: At Cloudnine, the consultations and treatment plansare

15. We striveto “providethe best fertility solutions and help realize your dreams ofparenthood “ transparent in its dealings, whichmany of its clients have referred as being a very positive development in this industry. It has been striving to implement the latest technologies to stay abreast in the healthcare journey to improve its outcomes. Cloudnine is opening more and more centres across the country so that larger array people can access its services. Moreover, it has the best professionals and largest group of doctors in the specialtyacross the country that can provide the best- in-class services. The organisation has also employed a full time medical director and an embryologist to provide uniform treatment across all centres. careful evaluation to ensure we have the best in the country, along with the best team of embryologists to givethe best success rates in thecountry. patient care; Silicon review awardfor 50 best companies to work for; Worldwide Achievers Business Leadership Summit Award for Best Women and Child Hospital in India; and Extraordinary award by Brand Vision, to name afew. Awards and Recognitions Cloudnine aims to be a revolutionary leader in the fertility space in Indiaby providing premier fertility solutions to men and women. It is already moving towards achieving this mission. The hospital chain has been honoured with various accolades and felicitations including Number one fertilityhospital in Bengaluru, number two in Chennai, number three in Pune- in All India Fertility & IVF Ranking Survey 2018 by renowned media house; India MART Leaders of Tomorrow Award; Time Research Healthcare Excellence Award; BIG Brands ResearchBusiness & Service Excellence Award; National Quality Excellence Award for Best Customer Service; Brand Academy Healthcare Excellence Award; 2014 Australian Service Excellence Award; CIMS Healthcare Excellence award for Hospital with highest standardin Cloudnine is driven by the vision of providing the best fertility solutions,by setting consistently higher standards for itself and striving continually to achieve them. With all the dedication the team has put in and with the world- class facilities provided by the organisation, it has reached closer to this vision. Cloudnine has been a part of my happy stories, aiding and assisting the people that seek help.This fast-growing, prominent hospital chain stands true to its tagline- “Pregnancy is wellness and not an illness and Menarche to Menopause explains all our upcoming products. We cater for every need of a woman and a child – we want the wellness to continue in the family”. The PerfectTeam Cloudnine has the flawless combination to deliver great service –a Founder and Chairman – a neonatologist who understands the nuances of premature babies with all medical aspects; and its fertility specialists across the country are chosen by the Chairman himselfafter

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17. MostAdvanced The IVF &FERTILITY Centres2018 1

18. Interview withInsightsCare OoWomaniya Revolutionizing & Offering a Comprehensive Health Solutions forWomen W omen health has been neglected for a long time now. In spite of beingthe nurturing hand of the home and family, this problem has persisted fordecades. OoWomaniya is a platform developed with the notion to provide womena chance to share and read about issues in “An anonymous and non-judgmentalenvironment.” Established by Sneh Bhavsar (Co-founder & CEO) and Krutika Katrat (Co-founder& CAO), the company is providing comprehensive healthcare information to women, and creating a revolution in the way women access this information. More than 7000 women have received help from doctors via online consultation and workshops, through OoWomaniya’s Health and Wellness Network. What is OoWomaniya? What’s the idea and concept behind your startup? OoWomaniya is an online community exclusively for women to access information, services and expert consultations on their physical, mental and emotional health and well-being. OoWomaniya was incepted with an idea to let women share their issues anonymously in a safe and non-judgmental environment. The platform on web and mobile evolved over the period to create a strong, trustworthy forum over 4 years for women to access credible information and services regarding their health andwellness. Who are the faces behind this startup? Sneh Bhavsar, 34, Co-founder & CEO (Chief Executive Officer)— Sneh pursued his graduation in Information Systems Management from University of London an worked in the IT industry for over 7 years before he plunged into staring his own business. Sneh has 12+ years of experience in IT and ITeS working with technologies, business analysis, process design, product planning, product design, management and recruitment. He is a member of Global Shapers Community, an initiative by the World Economic Forum and leads several initiatives personally andprofessionally. Krutika Katrat, 28, Co-founder & CAO (Chief Acquisition Officer)— She has pursued her M. TECH (Integrated) in Biotechnology from Pune and has pursued internships and projects while being a student at Zydus Research Centre, Zydus Manufacturing unit and Cadila’s Plant Tissue culture lab. She has worked as a research trainee in a DBT/DST project at ACTREC, Tata Memorial Centre, Navi Mumbai in the field of cancer biology and structural biochemistry before taking a plunge intoentrepreneurship. How have they helped build up thisplatform? Sneh and Krutika started OoWomaniya together with an intention to work in preventive healthcare combining their expertise. Sneh has contributed largely toward the product, technology and design of the platform along with managing the strategy of marketing, planning and acquisition of resources. Krutika’s background in clinical research brings alot 18| October 2018|

19. SnehBhavsar Co-founder &CEO KrutikaKatrat Co-founder &CAO |October2018|19

20. and the solutions we created – we struggled to monetize the idea forsome time. With several ups and downs, and finally pivoting to the community platform – we raised an angel round in 2016 and also won a couple ofgrants. 8. How do you think this venturehas revolutionized the way a woman approaches doctors? Online consultation is not a new concept but it is important to createan ecosystem around it in order to make the women feel safer, secure and non- judgmental. Also, women’s health issues are evolving rapidly due to the lifestyle and food and hence it is also essential that this ecosystem also educates them primarily about the issues they might befacing. OoWomaniya empowers womenwith the information on health issues and resources to take informed decisions about theirwell-being. 5. The name is quite interesting. Why did you name itOoWomaniya? This name is inspired by one of the songs in a regional language where Womaniya means a woman who is independent and takes her own decisions. That is at the core of women’swell-being. of expertise in healthcare contentand also acquiring the experts/doctors to contribute in building the repository. She engages with the community and looks after the businessdevelopment. 6. How OoWomaniya is different than other websites in the same domain? What makes OoWomaniya standout amongst the rest? OoWomaniya is the only platform which is exclusively focused on women’s over all health and well- being. It doesn’t encourage the market driven ideas of beauty, image and persona for women. OoWomaniya focuses on core healthiness, emotional wellness and freedom of choice for women. OoWomaniya also attempts to eradicate the myths and taboos around social and cultural practices which affect women’s well-being. 9. What’s your futureplan? Our web and mobile platforms are revamped and our immediate goals is to reach out. We will be acquiringmore users in coming months, expand the community across India and add more features and solutions related to women’s well-being incenter. 4. How did you start OoWomaniya? What was the motivation behind starting thiscompany? As we were extremely concernedabout the healthcare systems and how we can use the technology to create an intervention – we conducted a few workshops with the community. These workshops were the starting point for our research and we built a prototype on web to receive stories from women about their day-to-dayissues. 10. What is entrepreneurship according to you? Whatadvice would you give the budding entrepreneurs? Being an entrepreneur is more than building a product and doing sales and marketing. It requires you to learn every day from your own businessand being alert about the opportunities of innovation, collaboration and growth. Revenues are as important as the valuation and hence – focus on sustaining the business throughsizable revenue can be the best possible strategy tosucceed. 7. Establishing a startup is nopiece of cake. What amount of time and money did you invest in this venture? We have been working on our startup for more than 4 years now. We hadour share of struggles with the subject, with the perception towards women’s health and also sustaining the venture as a business. However, we were extremely confident about theproblem We found women’s health issues getting ignored significantly andmajor factors include social and cultural practices in India. Realizing it to be a long battle – we started with the venting platform for women to share their physical and emotional health issues. Feedback from women was a huge motivation to pursue the idea further and create a query to cure solution for the Indianwomen. 20| October 2018|

21. Community Care Collaboration (C3)Model CareTeams Family, friends and Professionalcommunitycare providers Mobilize CareActions Care instructions distributed via mobile devices sharedby Care Teams LifestyleSupport Access to lifestyle products/services tokeep people in theirhomes Because together, we’re better. Our C3 model – Community Care Collaboration – supports care programs that require high levels of collaboration between interdisciplinary care providers, patients, and family caregivers. Our goal is your goal: to keep patients independent, living comfortably in theirhomes. Care3.co

22. BarmadeHospital OfferingDistinctiveServicestoRealisetheDream ofMotherhood TObstetricsand Gynaecologydoctors’ he IVF industry is booming andthere will be IVF clinic in allpracticing clinics in the next 10-15 years. The globalIVF services revenue market is projected toreach $22,467 million by 2025, growing at aCAGR of 9.8% from 2018 to2025. This sector is anticipated to exhibit significant market growth in the coming years, owing to rise in infertility rate, increase in trend of delayed pregnancies, surge in IVF successrate, and rise in disposable incomeworldwide. One such sanatorium that works towards fulfilling the dream of motherhood for every female who is infertile is Barmade Hospital. Established in 2007 in the historic city ofLatur; the hospital set up Latur Institute of Fertility & Endoscopy (LIFE IVF) in 2010. Barmade Hospital is a fastest growing hospital inLatur. Dr. Kalyan B.Barmade Founder & ManagingDirector It is a fifty bedded hospital with exclusive Gynaecological and Obstetrics unit with ICSI set up, Endoscopy Unit, Sperm Bank, NICU (Neonatal Intensive Care Unit), Modular OT, Modular IVF Lab with AHU setup. We help to fulfil thedreams of motherhood for every female who isinfertile Successful Journey of BarmadeHospital Barmade Hospital started out in 2004 with only a consulting room and went to become a full- fledged twenty bedded super-specialty hospital in 2007. The hospital has now reached to fifty beds within span of fourteen years becauseof 20| October 2018|

23. 1 MostAdvanced The IVF &FERTILITY Centres2018 blessings from 5,000 plus couples who received treatment and got success in infertility and theirdream of parenthood being successfully completed. It has set up a unit in Latur (Marathwada zone); this isthe only super-specialty IVF/ICSI modalities. The patient load of Barmade Hospital has tripled in last 3-4years. Dr. Kalyan has single-handedly performed more than 8,000advanced endoscopic surgeries. He asserts, “Latur fertility centre has given joy of motherhood to more than 5000 patients.” He has trained more than fifty doctors in laparoscopic surgeries, and has also extended his service nationally andinternationally. He has conducted live endoscopic workshops and participated in various infertility and endoscopy workshops inIndia. Awards andAchievements Dr. Kalyan & Barmade Hospital has received many acclaims in field of Art & Endoscopylike; • Rajiv Gandhi Gold Medalat Bangalore • IMA STAR award at Latur, Icons of Latur Award by LokmatMedia • IMA appreciationAward • Dr. R. K. Menda trophy for community service projectby IMAMaharashtra Skilful Visionary behindthe Hospital Unique Services atBarmade Hospital Instigated by Dr. Kalyan B. Barmade and Dr. Manisha K. Barmade, it caters to over two thousand OPD patients a month and 30-40 IVF / ICSI related services a month. Dr. Kalyan is Undergraduate and Post Graduate from esteemed KEM Hospital and N.Wadia Hospital, Mumbai. He is practicing in Latur since 2004. He has completed his specialization and training in IVF from ASSUTA University, Tel Aviv, Israel and from esteemed Dr. Nadkarni from Gujarat, respectively. Dr. Kalyan is one of the leading gynaecological endoscopic surgeons and fertility specialist inthe country. His fields of expertise include hysteroscopy, laparoscopy, microsurgery, assisted reproduction and sonography. But above all from his vast experience as a surgeon, he has carved a niche for himself in his field of expertise. He believes that the prospectus in rural India is great, and there is a need for special clinics in rural India to give benefit to 70% of population staying in this part of thecountry. Dr. Kalyan has been elected onIAGE (Indian Association of Gynaecology and Endoscopy) as executive committee member, AMOGS (All Maharashtra OBGYN Society) executive member, and MISAR (Maharashtra chapter of Indian society of assistedreproduction). The hospital provides a plethora of services to its patients. The Latur Fertility and Endoscopy center hasa Test Tube Baby (IVF& ICSI) and Yashodip Sperm Bank. Apart from these the hospital also provides facilities thatinclude: Working for a SocialCause •Two ICSIunits •IMSI (Intracytoplasmic Morphologically-selected Sperm Injection) •Laser HatchingServices •Embryoscope (Primo Vision) Services available at LIFEIVF The hospital is planning for the successful integration of CASA, PGD/ PGS and other state-of-the-art services for poor patients in rural India. As a social initiative, the hospital has also done thousands of plantations in drought affected area of Latur. It organizes yearly twofree camps for underprivilegedpeople. Barmade Hospital has been contributing, for the past ten years,as a community service to maintain and educate village girls’ about menstruation hygiene, anaemia and plantation. The Barmade Hospital is looking forward to the installation of CASA (Computer Assessment of Sperm Analysis) in the next few months.An integration of these services will improve success rate, while services like PGD will help to select genetically abnormality free baby in nearfuture. |October2018|21

24. UrinaryProblems inGynaecology Ucomplaints of the rinary problems are themost into the bladder, due to anatomical reasons – urethra is shorter in females than males, and is closer to vagina and anus. Some factors like poor personal hygiene, sexual intercourse, catheterization, pregnancy, and menopause make women more susceptible to UTIs. Symptoms and signs of UTI are painful micturition, increased frequency, urgency (strong urge to urinate), burning sensation, cloudy or blood stained urine, foul smelling urination, mild fever and/or passage of frequent small amounts of urine; if the infection reaches the kidney-high fever with or without chills, nausea, vomiting and pain in back radiating on one side. Diagnosis is made by characteristic symptoms and by urinary examination- urine may contain pus and organisms. Culture and microscopy of the discharge helps in establishing thediagnosis. contraceptives and douches.Alkaline drinks and citrates arehelpful. Menopausal women may benefit by supplementing oestrogen (hormonal) creams to improve the atrophic (thin and shrunk tissue) state of vagina and urethra. Some preventive measures can be followed to avoid UTI: like use a 100% cotton inner wear, maintain proper personal hygiene, urinate after intercourse, use proper antibiotics as advised, cranberryjuice can help in decreasing number of UTIs, have plenty of oral fluids, use lubricated condoms without spermicide creams and most importantly proper toilet training should befollowed. frequentlyencountered gynaecological patients visiting the outpatient department. Several causes contribute to the varied presentations and types of theurinary problems. The establishment of a proper diagnosis involves a detailed history, meticulous examination and a complete urological investigation. Common urinary problems that patients present with include Urinary Tract Infections (UTI), retention of urine, difficulty in micturition, painful micturition, increased frequency of micturition, difficulty in controlling urination, involuntary passage of urine on cough or sneeze, abdominal pain associated with micturition and increased night frequency of micturition. Let’s concentrate on a few of these complaints in thisarticle. Coming to the next common urinary problems which most women elicitin their history either as chief complaint or on enquiring include frequency of micturition, urgency to urinate and/or inability to control urination or involuntary passage of urine (incontinence). Incontinence affects nearly 400 million peopleworldwide. Studies have found the incidence as high even in younger population, affecting nearly 24% women between ages 18-44 years.Urinary Treatment consists ofadministration of large quantities of fluids, atleast 2.5 litres/24 hours, especially in cases of cystitis (inflammation of bladder) and appropriateantibiotics. Patients are advised to avoid all irritants like deodorants,vaginal Urinary Tract Infection(UTI) It can be an infection in any part of the urinary system from kidneys to ureters to bladder and/or urethra. Most common method of infectionin women is ascending from theurethra 22| October 2018|

25. UTI inGynaecology About theAuthor Dr. Nishita Shah has completed her MBBS, DNB, ICOG fellowship in Reproductive Medicine (Mumbai). She is practicing Gynaecologist, with special interests in Urogynaecology and Infertility. She has been the Youth Council Member in Mumbai Obstetrics and Gynaecological Society for over five years. Dr. Nishita works as Consultant Obstetrician & Gynaecologist at Opera House, Kemps Corner, Colaba; Hospital Attachments: Bhatia hospital, St. Elizabeth’s Hospital, Surya Mother and Childcare Hospital, Shanti Nursing Home (Ghatkopar), Apollo Spectra hospital, K. J. Somaiya Hospital. She has five years of experience in practice, and has won prizes and awards at National and International Conferences for various paper and video presentations. Nishita has authored and co-authored chapters in different textbooks and publications in journals. Dr. Nishita Shah ConsultantObstetrician &Gynaecologist incontinence is a worldwide problem and the burden is expected to grow with an ageing population with longer life span and availability of better healthcare facilities. In women, pregnancy, childbirth, and menopause are major reasons for increased prevalence of incontinence. Although Urinary Incontinence is not a life threatening problem, it negatively affects the quality of life; may cause emotional problems like depression, anxiety, stress, and embarrassment in public impacting their travel, exercises, and sexual activity as well. Thus it is animportant public health problem which needs to be addressed not just medically, but socially also. The common causes which are postulated to precipitate urinary incontinence are genital prolapse (weakening of genital tissues leading to their prolapse outside the vagina), type of childbirth, and longer duration of delivery, number of children, urogenital infections, and injuries to the genital regions, genetics andmenopause. |October2018|23

26. tress Urinary Incontinence (SUI) is the commonest cause of urinary incontinence notedworldwide. Spressure, whichoccurs during physical activities like coughing, sneezing,running, lifting heavy SUI is involuntary loss of urine from the urethra when there is increase in intra-abdominal weight or exercise. Diagnosis is made during detailed history of the symptoms, along with important past history relating to injury to the genital tract (example during child birth); followed by meticulous examination of the patient in supine (lying down), standing, and squatting positions. Urodynamic tests focus on the bladder’s ability to hold urine and empty steadily and completely, that is, a study that assesses how the bladder and urethra are performing their job of storing and releasing urine. Sonography and cystoscopy (a tube with a camera and light to visualize the inside of the bladder) are other tests which may be individualized as per the patients. Treatment options for Stress Urinary Incontinence are non-surgical and surgical. Non- surgical therapies include behavioural therapy like bladder training, fluid, and diet modification, Kegel’s exercises and Pelvic floor muscle training and drug therapy. However, surgical therapy is well established and over 200 different surgical procedures are described. Most effective and durable long term therapies are Surgical. The goal of the surgical treatment is to provide sufficient urethral support to prevent urine from leaking in cases of increased intra-abdominal pressure. When determining the optimal surgery for a patient, factors to be considered include type of SUI, bladder capacity, severity of the problem, associated other conditions which may require concomitant surgery (like prolapse). There are many modifications since the advent of surgeries for SUI, to name the most common ones performed- Kelly’s plication, retropubic suspension ( Burch colposuspension), Laparoscopic Procedures, Trans Vaginal needle suspension procedures, sling surgery ( mid- urethral polypropylene mesh, Tension free Vaginal Tape, Trans Obturator Tape), bulking agents, etc. Sling surgeries are the most popular and easy to performsurgeries. The choice of the surgery depends on the cause of urinary incontinence and thus to ensure optimalefficacy of the selected procedure with reduction in risk of complications, careful patient selection is amust. The other common complaints are increased frequency of urination- day and/or night, inability to reachthe washroom when there an urge to pass urine (urgency) and inability to hold the urine before reaching the toilet with some amount of leakage of urine (urge incontinence). In these patients detailed history especially of any associated medical conditions (like diabetes, high blood pressure on treatment) isvital. Urinary infection is also ruled out in patients with these complaints. After the diagnosis is confirmed, the treatment is mainly pharmacological and non-surgical. The underlying medical condition should be addressed along with the treatment for the urinary complaints; minimizing the side effect profile of these medicines. The treatment is always individualized depending on the severity of the problems. When patients have mixed symptoms along with SUI, non-surgical or pharmacological methods are preferred as first line treatment followed by surgery for SUI ( if needed).Thus, to conclude, urinary symptoms are commonly encountered problems in gynaecological practice and it is of utmost import e to focus onits prevention along with treatment, eliminating their negative effects on the quality oflife. anc 24| October 2018|

28. International FertilityCentre AReveredDestinationwhereLostHopeturnsinto JoyfulBlessing P arenthood is the biggest blessing of Godto the mankind. But sometimes, Goditself does not shower equal happinessamong all of its beloved children and lets themwalk empty handed with sorrow, anxiety, and deep pain. Delhi-based International Fertility Centre (IFC) gives hope to those who are left in despair due to infertility problem and brings happiness to their gloomy faces with its state-of-the-art fertility treatment. This prominent fertility center has gained global recognition due its precise and result-driven fertility treatments. It was incepted in the year 2012 and since then it has witnessed meteoricrise and colossal success in fertility vertical. It has built a robust network of ten IVF clinics across the length and breadth of India and even expanded its business footprint in the neighbouring Himalayan country-Nepal. Headquartered in the national capital, IFC is mentored by India’s leading IVF specialist Dr. Rita Bakshi with the diligent support from an adept team of medical practitioners, who knowall the nitty-gritty of fertilitytreatment. SaarthakBakshi CEO Championing the cause of parenthood withadept IVF specialists,state-of-the-art infrastructure, andleading -edgetechnologies Today, there are millions of people across the world who suffers from the trauma of infertility. Reproductive techniques, such as in-vitro fertilization, are the hope to the millions who want to attain parenthood. IFC is a trailblazer and an expert in IVF, who treats both male andfemale infertility issues with utmostcare. Reasons behind its ColossalSuccess IFC has state-of-the-art lab with latest world-class technologies and equipment’s that cater theneed 26| October 2018|

29. 1 MostAdvanced The IVF &FERTILITY Centres2018 of different patients who come for various fertility treatments. Providing services that match with the international standards has alwaysbeen the main focal point of IFC. It has cutting edge equipment’s, which are the latest ion the industry and provides the best result. The team is as good as the technology it works on and hence Dr Rita Bakshi always believes in up gradations and trying out the newesty best technical innovations in the fertilityindustry. In cases where intrauterine insemination fails, it offers in-vitro fertilization treatment where the fusion of male and female gametes takes place outside the human body in apetri dish and then the resultant embryo is transferred to the uterus of the mother. There are cases where IVF doesn’t work, for instance, if the sperm count is very low or the woman is in advanced maternal age resulting to decline in the quality of her eggs. In case of low sperm count, IFC offers intracytoplasmic sperm injection, a technique that allows the specialists to choose one high grade sperm with good morphology and motility that can be injected directly into the egg and then the formed embryo is implanted into the womb of the intendedmother. the chances for infertile coupleseven in rare cases,” statedIFC. IFC’s CEO is the Beacon of Hope “Fail fast and rise early,”- It even takes courage to spell the word ‘Fail’, Saarthak Bakshi lives his life believing in this great philosophy every day. He is the Chief Executive Officer (CEO) of International Fertility Centre who never hesitatesto take calculatedrisk. His relentless desire to succeed; sharp business acumen, and aptitude tosolve any crisis in no time- makes him the entrepreneur of new-age that don’t only has vision but also the passion to transform his dreams intorealities. IFC is the only destination in North India to offer CASA – Computer Assisted Sperm Analysis, which performs the widest range of sperm function tests. Since its inception and up until now, IFC has performed more than fifteen thousand IVF cycles and has the highest success rates in every fertility treatment, as compared to any other clinic. Along with good success rate, the increased live birth rate ofthis hospital tells the prominence of its services. This is the reason IFC has been voted as the Most Trusted IVF Brand of India in 2018 by Indian Education Excellence Awards,2018. Saarthak is a graduate from renowned institute – Indian School of Business. He has worked with reputedcompanies - Infosys and Ernst & Young – and then moved onto different entrepreneurial ventures that gave him a lot of insights and in depth acumenof running abusiness. In case where age is the major factor, IFC offers the option of egg or sperm donation for the intended parents. As for women with uterine issue or ifthey have their uterus removed due to medical condition then IFC provides them surrogacy as an option wherein a surrogate mother, a third party agrees to carry the child for the couple. The healthcare provider also offerssurgical treatments to overcome infertility issues. Today, along with his mother he has taken the fertility industry to adifferent level all together and as a result everybody know how successfully International Fertility Centre isrunning by creating life and giving hope to infertilecouples. Although IFC and its specialist have received many awards but they considers giving smile on the faceof infertile couples is their real award which they want to win from every singlecouple. IFC has already successfully implemented physiological intracytoplasmic sperm injection (PICSI), pre-implantation genetic testing (PGT), which includes pre- implantation genetic diagnosis (PGD) and pre-implantation genetic screening (PGS), percutaneous epididymissperm aspiration (PESA), testicular sperm aspiration (TESA), sperm slow and DNA fragmentation index. “We are looking forward to adopt new techniques that can help us to give better success rates and canimprove “We will try our best to raise awareness amongst the masses andto tell them how few trivial lifestyle changes can help to thwart infertility and to experience the bliss of parenthood,” concluded theCEO. Services and Products of IFC IFC provides varioustop-notch services, which includein-vitro fertilization (IVF),intrauterine insemination (IUI), intracytoplasmic sperm injection (ICSI), eggdonation, surrogacy, assisted hatching, hysteroscopy, laparoscopy, and many more. Recently, Forbes has recognized his caliber as a leader and featured him in its issue of- “Forbes 30 under 30ASIA, 2017 for HealthCare andScience.” |October2018|27

30. New-age Techniques that can PreventLife- Threatening Diseases amongInfants 28| October 2018|

31. Advances inIVF E very parent wants their child to be delivered healthy and is able to live a healthy life. While living healthy afterbirth depends upon many factors like nurturing, proper diet, health awareness, exercises, good sleep, and more,the circumstances during the childbirth are quite different. There are things which one couldn’t control earlier, that isthe case of some defective genes in father, mother or in both. But with the advent of landmark IVF treatment andsuccessive progression towards its improvements have gifted this world many popular, sometimes controversial but effective medical techniques that can prevent the transfer of faulty genes into the child and ensure a good health of baby on itsarrival. Karyomapping and three parents IVF are the few techniques which have even got the acceptance (both in legal and societal aspect) in many countries, including the UK. Karyomapping People are often affected with lethal genetic diseases, which many a times transfer to their dear ones and drastically affect their health and well-being. While in the process of expecting a child, its health is always a matter of great concern for the families and especially for the parents. With hectic life schedule, bad food habits, work pressure, loneliness, depression,and more, people often suffer from many life-threatening diseases like diabetes, mental illness, and manymore. No parent, even after knowing that they are suffering from a particular genetic disorder, will ever want to let affect the health of their new baby in a negative way. Now with the advent of Karyomapping, a couple can avoid passing a genetic disorder on to their offspring. In this revolutionary technique, embryos get screened before getting implanted into the mother’s womb (uterus). This method is also known as pre-implantation genetic diagnosis or PGD forshort. In-vitro fertilization (IVF) is needed to carry out this technique successfully. In this process several eggs get collected from the ovaries and then are fertilized outside the body using previously extracted sperm, to produce embryos. Each embryo is then screened, on various parameters, to check its health. Karyomapping technique scrutinizes the chromosomes of the mother, father, and the reference at 300,000 different points. Through this method, doctors can find the defective embryosand precisely remove those from the IVF process. Only the embryos that are free from any genetic condition are transferred tothe |October2018|29

32. uterus. In this way one can ensure a healthy life for the new born and can also reduce the probability ofmiscarriage, significantly. Three Parent IVF or PronuclearTransfer Mitochondria are small organelles that sit inside our cells and provide vital energy to it. Mitochondria also play a vital role in the respiratory process. But when this significant organelle of our body gets defected, it invites a plethora of life-threatening diseases. A recent study revealed that many children every year are born with faulty mitochondrial DNA, caused by mutations inthem that affect mitochondrial function. Its symptoms includes: heart disease, liver disease, kidney disease,poor growth, loss of muscle coordination, muscle weakness, neurological problems, autonomic dysfunction, anddementia. Mitochondrial disorder becomes worse when the faulty mitochondria present in the muscles, cerebrum, or nerves as these vital parts of our body require more energy as compared to other parts. Mitochondrialdiseases strike early in childhood and get worse steadily and even prove fatal beforeadulthood. Mitochondria replacement therapy is a controversialbut effective technique, which can be used to prevent the transmission of mitochondrial diseases from mother to child.This procedure is used in cases when mothers contain genes affected with mitochondrialdiseases. Mitochondrial donation, also known as three parents IVF, is said to be the solution for the problem mentioned above. In this method, a third party donor, apart from the father and mother, gets involved in this well-known IVF process. The donor’s healthy mitochondria are used and the nuclear DNA from the third party is removed and replaced with DNAfrom the both. Many would think that when a third party gets involved in the fertility process then it may also claim some right over the child. The answer is NO. The third party donor does not have any right over the child and his/her identity is always kept as a secret. Third party donor is not even involved in the upbringing of the child. Even if we talk on genetic level, all of the 20,000 genes on the child’s 23 pairs of chromosomes come from the child’s original mother and father. The donor’s contribution here remains miniscule- less than 0.2% of the total that too in the DNA that concentrated in themitochondria. Recently, a 34-year-old Ukrainian mother has been gifted with a healthy child with this IVF procedure, which is also sometimes known as pronucleartransfer. Although, these techniques are gaining popularity due to their effectiveness and many countries have even made these processes legal, but still these techniques have to test the waters concerning its broader acceptability. Only time will tell how far these techniques will impact both- in the domain of healthcare, especially IVF, and in the hearts of infertile couples struggling with genetic disorders. It will be very interesting to watch what the future holds for these intriguingtechniques! 30| October 2018|

34. KGN Test-Tube BabyHospital & ResearchCentre Cherishing Motherhood at itsBest Hblessing.Apoint comes in the life of aving a baby is a feeling which can’tbe expressed in words; it’s truly a delight,a every couple, where they desire to expand their family and welcome a new member. But, some couples fail to enjoy this bliss due to various medical issues and unknown reasons. The situation has now been amended, all thanks tothe tech-enabled advancements in medical science. Today, there are several options which canhelp fulfil this desire. Healthcare industry isembracing these advancements and converting every challenge into opportunity to help couples suffering from infertility problems across the globe. KGN Test-Tube Baby Hospital & Research Centre established in 2000, is Latur’s, first infertility and test tube baby center. In 2004 KGN Infertility Centre became KGN Test-Tube Baby centre and is also one of the leading fertility units in India. With an aim to offer the most advanced and globally competitive ART (Assisted Reproductive Technology) programs andservices, the hospital has been in the field of infertility for the past ten years. It is a well-equipped centre with the state-of-the-art Embryology Laboratory. Its eighteen years of fertility practice along with 12500 live births clearly states its success journey to motherhood. By supporting couples facing problems of infertility, KGN has set its benchmark atLatur. Dr. AamirShaikh Founder Our Motto is notPregnancy, Our goal is delivery of HealthyBaby KGN has a competent team of doctors, Andrologists, Anaesthetists, Paediatricians, scientists, technicians and paramedical staff including medical social workers,counsellors, 32| October 2018|

35. 1 MostAdvanced The IVF &FERTILITY Centres2018 donation programme promoters and surrogacy promoters who work together to achieve world-classsuccess rates in its IVFProgramme. high-class competent services at a very economical professional fees. This objective has enabled its unit to be at the forefront of offering fertility services and treating numerouspatients from India, Pakistan, and Saudi- Arabia. best infertility specialist at nationaland international conferences. It has successfully collected many jewels in its pocket among which the feware: Meet the Intuitive HealthcareExpert Dr. Aamir Shaikh is the Founder of KGN Test-Tube Baby Hospital & Research Centre. He has completed his post-graduation MD, DGO (Diploma in Gynecology and Obstetrics) from JJ group of hospitals with FCPS (Fellowship of the College of Physicians and Surgeons) and DFP (Diploma in Family Planning) from Mumbai University. Dr. Aamir is practising medicine since the past 32 years. He received formal training in Assisted Reproduction, at various prestigious IVF (in-vitro fertilization) Centres like Lilavati Hospital Mumbai, Purandare Hospital and Melbourne IVF centre, Ahmedabad. With over twenty-six years of medical practice, Dr. Aamir has been actively performing ART in India for the last tenyears. • Rashtriya Chikitsak RatnaAward, New Delhi • Bhartiya Chikitsak RatnaAward, Pune • Marathwada ChikitsakRatna Award • Latur ChikitsakAward • Muslim BhushanAward • IMA Best DoctorAward • Invited as a best ART specialistat Munich (Europe) and Bangkok (Thailand) KGN is on a mission to provide complete medical care experience to the people by keeping abreast withthe latest technology and upgrading its teams’ expertise with international training experience. Armed withhigh- end machinery and instruments imported from around the globe, the centre is offering quality at itsbest. KGN is the first unit in Marathwada to initiate the technique of AssistedLaser Hatching, to improve pregnancy rates in elderly patients and in previously failed cycles. The unit has started performing Blastocyst Cultures. The centre has expertise in the area of Egg Donation and Embryo Donation, which is a boon to elderly and menopausal women. A ComprehensiveVision Most of the IVF centres are located in metropolitan cities where the infertility patients are unable to reach. It is essential to develop IVF hospitals in the rural areas also the rural population believes that IVF babies are notnormal and the treatment is highly expensive. Therefore, with a vision to deliver super specialty treatment at low cost, KGN settled in Latur. It is giving cost- effective best-in-class services in infertility international treatment and aims to eradicate all infertility related problems from thesociety. Besides conducting his own ARTunit, he is also an honorary Associate Professor at the Maharashtra Institute of Medical Science & Research (MIMSR) Medical CollegeLatur. Since inception, the hospital is smoothly performing state-of-the-art IVF treatment at affordable prices in a comfortable atmosphere. It is crafting out all the newest reproductive techniques, including ICSI (Intracytoplasmic Sperm Injection), Embryo Freezing, Embryo Biopsy,IUI (Intrauterine Insemination), TESA (Testicular Epididymis Sperm Aspiration), Surrogate Mother, Ovum donation, Sperm Donation, Cryopreservation and soon. Healing Lives byEmbracing Technology “Our aim is to offer the latestservices, with success rates equivalent to the West, at very affordable costs, but without compromising on quality,” says Dr.Aamir. Believing in the age-old dictum - prevention is better than cure, KGN has been embracing latest equipment, best-quality disposable culture media imported from the West anddelivering Awards andRecognitions Over the years, KGN’s sheer dedication and unified efforts has helped it to attain many awards asa |October2018|33

36. 6 Intriguing Facts Infertility isn’t asuncommon as you would think. When you are trying to get pregnant, it feels like everyone around you is a Fertile Myrtle. There is a baby in every abdomen that walks by…or so it seems.In Concerning IVFthat You MustKnow fact, infertility affects about 12% of the population soyou are definitely notalone. 3 1 2 Louise Joy Brown (born 25 July 1978) is an English woman known for being the first human to have been born after conception by in vitro fertilization, or IVF. Her birth was heralded aroundthe world, with headlines declaring that the first test-tube baby had been born. The announcement was met with excitement from some, fear and hostility from others. But one thing was certain: This was truly the beginning of a new era in how babies are created. Since 1978, over 8 Million babies have been born through IVF. Acupuncture, which involves inserting fine needles under the skin at particular points in the body depending on the condition being treated, has long been used in China to help with a range of diagnoses, including regulating female reproduction. In a study itis found that Acupuncture can increase the chances of getting pregnant for women undergoing fertility treatment by65%.

37. Fertilization Rate is higher in Eggs Subjected to Music! A study was done at Institute Marques fertility Clinique in Barcelona Spain with 1,000 embryos. 500 were subjected to music during IVF. Thisincluded a variety of genres and artists played 24 hours per day such as Mozart, Madonna, Metallica, Nirvana and MichaelJackson. The other 500 embryos did not have access to music in their incubators. For the eggs fertilized, rates were higher by 5% in incubators in whichmusic was beingplayed. Eggs harvested does not equal eggs fertilized. Your eggs willbe carefully screened to make sure they have everything required to produce a healthy embryo. So, although your doctor may harvest 10 to 20 eggs, it may be that only a small portion ofthese can actually be used to create embryos for IVFtransfer. 5 6 4 Rajo Devi Lohan is the World’s Oldest Mother with IVF Treatment. Rajo Devi Lohan gave birth in 2006 at the age of 66 (and 358 days) to twin boysin Giuleşti Maternity Hospital in Bucharest. She received much criticism at the time for her age, which she defended firmly. She admitted to fabricating her age in order to receive treatment because she had so desperately wanted achild.

40. How to BecomeMore Courageous andResilient in ourlife? C ourage is aboutchallenging Your ability to stay resilient and relevant as a sentient being is thekey to implementing and maintaining a courageous and vibrantlife. being courageous is inconvenient and interrupts your cozy life; sometimes being courageous upsets others inyour environment. yourself, reaching beyondwhat is normal, and changingin ways that increase your potentialfor growth andtransformation. There are no ground rules to accepta courageous challenge. The only requirement to be courageous is to understand that you are goingabove and beyond the normal range of activity in yourlife. Facing YourFears Many of times in my medical profession maximum infertile patients are frustrated so when they enter in OPD they have extreme fear about treatment. Once they get assurance about treatment, then second fear is about success. Means the infertile patient has many of fears on everystep of theirtreatment. The key to breaking the fear barrier is to seek balance in your life –balance derived from values based on beliefs and heart centered thinking and behavior. When you are balanced, you can take risks; make gloriousmistakes, and plenty of leaps-of-faith. In other words, you have the courage to do what comes from your heart, and you can take responsibility for what you can control, even in the face offear. Right from our childhood to last journey of our lives, we must think about the colorful rainbows in dryand dark sky. No matter that, no one believes in you, no matter that your value is zero in society. Just start to believe in yourself and make yourself very precious to youonly. In theory, you know that fear is an irrational state of being. If it is irrational, then why are you fearful? Perhaps fear is recognition that you have not fully and willinglyaccepted yourself. To be courageous, feel the fear and don’t run away from it. Then go anddo what you fear. When my patients ask me about whether they will enjoy parenthood or not, that time I ask them that “Ask yourself- What’s the worst that can happen?” Try to imaginewhat would be the worst possible outcome of your fears and write it down. Not only does admitting your fears lessens its impact, but also writing down your fears is a courageous act in and of itself. Resilience is that ineffable quality that allows you to be knocked down bylife and gives you the courage to come back stronger than ever. Rather than letting failure overcome you and drain your resolve, you gather yourcourage, face your fears, and find a way to rise from theashes. So, you resist and create artificial boundaries to stay in that familiarplace of resisting. This is the opposite of courage. During counseling I must try to make them bold to face each and every failure alone & be ready for next challenge. Due to this you become more courageous to taking responsibilities of your failures. This cycle will help you to become more confident for the next stand. Being courageous, taking responsibility for what you can control even in the face of fear and exceeding yourself is by no means an easy journey.Sometimes • The following are maincharacteristics ofresilience: • positiveattitude • optimism • ability to regulateemotions • the ability to see failure as a formof helpfulfeedback Change Your Story from Infertility to Maternity Is the Total Positive Attitude If everything is perfect in yourlife, leave it alone if you are comfortable. But if you want to take a risk, if you feel a passion to embrace anotherway 38| October 2018|

41. Resilience &Courage About theAuthor This interesting article has been penneddownbyDr.RaziyaShaikh, who is a M.D. (IVF Centre) & Gynecologist at KGN Test-Tube Baby Hospital. She is practicing Gynecology for the past 20 Years. ShehasworkedasaRMOatCama & Albless Hospital under prestigious Grant Medical College and J.J Group of Hospitals, Mumbai. She received formal training in Assisted Reproduction, at various prestigious IVF Centers. She has also developed ovum donation, embryodonation&surrogacy programs in rural India, at affordablecostforpeople withhumble backgrounds. Dr. RaziyaShaikh M.D.(IVFCentre)&Gynecologist of thinking and living, create that story by journaling. Tracking a different narrative gives you an opportunity to forceanother course in life or experience theinexperienced. “Make small intentions throughout the days to simply be yourself,” one of the most effective ways to think about living courageously is to create intentions within your immediate and natural environment. Then, through your own process of discovery, courage will follow. Many of ambitious people are not successful in their businesses and big planning. Whatever dreams you had seen for your life were not supposed to become successful so try to make small intensions dreams to become happy and successful life. Don’t try to run behind the false imagination just think real of the real image of life, and you will succeed more inlife. One of the most effective ways to move into a new reality is to control your imagination. Don’t let your imagination run amok, because an uncontrolled imagination can be your adversary. Distorting reality will not allow for opportunities, possibilities, and explorations. Focus and face life in the present. Believe in yourself and then move forward with courage. How good are you at making changes to your life when you need to? Most of us find change to be challenging and difficult. Yet you intuitively understand that the easier you adapt, the more interesting and challenging your life willbe. |October2018|39

42. Nutr”ional Pregnancy Desideratum during Pwoman.This is the period regnancy is asignificant Implementation of Nourishment for theFetus that the babies developing bones, teeth and muscles are healthy.Some variants of yoghurt also contain probiotic bacteria that are very important for digestive health and assist in constipation during pregnancy. Consumption of milk may also help in reducing the chances of pregnancy related complications. moment in the life ofa Food is the element that helps humans survive and provides them with energy to carry out theirday-to- day tasks. The ingested nutrients, upon getting absorbed into the body, start building up the body and repair it from within. Similarly, for women who are expecting, they need to double the nutrition as it needs to be balanced out for the growth of the baby as well as energy for the mother. Here are some of the things to add into the diet compulsorily to ensure a healthypregnancy. where the individual needs to take good care of herself and ensure that she includes an equally healthy diet into her daily regime. This is where the nurturing of the child starts and helps it grow in an ideal environment. The fetus growing inside the womb relies entirely onthe food consumed by the mother. It is hence necessary to supplement it with foods containing more calcium, folic acid or folate, iron, and proteins. The intake of fruits and vegetables needs to be taken seriously as incorporating an assortment of them into the diet can prove to facilitate more vitamins and minerals within the body. Legumes – These small pods are rich in iron, protein and folate. Duringthe first trimester it is essential that both the mother and fetus receive folateas it is possible that the chances of low birth weight are reduced. The fibers present in it also help in preventing hemorrhoids for the duration of the pregnancy. Dairy Products – The need to consume foods that are rich in protein and calcium is at its peakas this is a major requirement for the fetus’ bone health.The high quality protein mainly casein and wheyare found in dairy products alongwith magnesium, phosphorousand zinc. Yoghurt is a rich source of all theabove nutrients especially calcium givesassurance Fish – This is also a natural sourceof vitamin D which is good for the hair as well as nails. Consumption of fish helps in providing the body with Omega 3 fatty acid. The fetus’ brain and eyes are built using this nutrient but fish like salmon should be consumed in moderation. The risk of impurities or large quantityof 40| October 2018|

43. PregnancyNutrition mercury does exist, but nonetheless, the occasional sea foodcan help in fulfilling this very important dietaryrequirement. Broccoli and Dark Leafy Greens – The presence of fiber, vitamins C, K, folate and potassium in these vegetables holds various benefits for both. These are rich in anti – oxidants that may help in preventing cancer, arthritis and Parkinson’s disease as well. It can also help in reducing the risk of low birthweight. The likes of Spinach, Kale and Arugula are crucial for the purification of blood aswell. Whole Grains – Grains like whole wheat, whole oats, barley and quinoa help a pregnant woman fulfill the daily calorie requirements. This is especially necessary during the secondand third trimester as the growth of thefetus is the fastest and the body requires energy to carry out everyday functions as well. They also contain magnesium which may help in relaxing the muscles and also preventing the uterus from contractingprematurely. Fruits – These contain natural sugars that can help with the sweet cravings as well. Avocados contain more folatethan any other fruit apart from which italso |October2018|41

44. contains vitamin C, Vitamin Band choline. They also contain iron,an essential for the blood health of the motherand the fetus. The potassium also may relieve legcramps that are a common occurrence during pregnancy. Bananas are also helpful in giving the woman’s body the required amountof potassium. Apart from this berries contain flavonoids and carbohydrates that can give the body a boost of energy. The entire duration of pregnancy maybe exhausting but nonetheless, it’s all about consuming the right food that will bring good health to the mother as well asbaby. Water – Finally, the elixir of life – water, is extremely important in any case. This is one fluid that helps in maintaining overall health. During pregnancythe blood volume usually increases considerably. The water helps maintain this level and also helps in reducing the risk of urinary tractinfections. Imperative Pre-requisites for a Safe and HealthyPregnancy In the entire term of pregnancy it’s necessary for the mother to get lots of sleep. Ina lot of cases, women tend to lose out on sleep due to bodily and hormonalchanges. But rest is required to help the body relax and heal. No matter at what point of the day, if one feels the need to sleep they need to ensure to get the desired amount of rest especially in the final trimester. It is also necessary to implement some light workouts which may reduce the chances of drastic weight gain, mood problems, and muscle pain which are very common. The doctors themselves usually suggest these exercises which will help refresh the mind and body as well. The things to avoid would be eating raw meat which may contain various harmful bacteria and also avoid getting into a hot tub as the high water temperatures maybe harmful for thefetus. The food consumed during pregnancy always has an effect on the energy and wellbeing of the mother. Hence it is necessary to maintain a healthy practice to ensure the healthy growth ofthe baby and a well-nourished pregnancy. 42| October 2018|

46. Mannat Fertility-IVFCentre A Blessing inDisguise Icouple ever experiences together.There is nfertility often creates one of themost distressing life and unfortunate crises thata one clinic that gives hopes to thedistressful couple and offers a comprehensive rangeof fertility services, namely, MannatFertility-IVF Centre. Its fertility experts understand the emotional aspect, and provide an ethical and meticulous research-based approach to fertility treatment. The centre provides wide ranging solutions that include IUI Treatments, IVF Treatments, ICSI, Surrogacy Options, Egg and Sperm Donation, Freezing, Blastocyst Transfer and Gynaecological Services that are among the best in the region. “We pride ourselves in our ability to offer all our patients the very best care,” asserts the Director. Situated in the City of Gardens, Bengaluru, India; Mannat Fertility Centre is an IVF clinic, which provides a wide range of solutions in the field of fertility. The IVF cost in Bengaluru and in Indiais skyrocketing with each coming day, but Mannat’s services is making these available at reasonable costs, as well as providing these at the hands of the top IVF doctors in Bengaluru. This is one of the key reasons behind its stupendous growth in Bengalururegion. Dr. ArchanaAgarwal Director A holistic & healingjourney towards parenthood The clinic takes utmost care of all its patientsand ensures that it offers customised solutions and all its patients’ needs are met in the best possible way. “Mannat is evidently the best IVF hospital in Bengaluru, India because it has a great track record of handling all kinds of complicated fertility related issues,” asserts thecentre 44| October 2018|

47. 1 MostAdvanced The IVF &FERTILITY Centres2018 spokesperson. “We at Mannat understand that infertility can create distress in the lives of couples who dream to have a happy and a life fullof joy.” Its team of highly qualified doctors make every effort to helps one reclaim onesdream. able to increase mortality rate,decrease biological age, reduce stress and bring peace to its patients to understand why they are going through thisproblem. Gynaecologist/Obstetrician, at Mannat. She has received trainingfrom Jhansi Medical College, for both undergraduate and post-graduate, and Batra Research Centre. She undertook further training both in India and abroad for ART (Assisted Reproductive Technology). She has been in practice for the past 20 years and is one of the forerunners in ART in the country. She has been a visiting Consultant to various major & midsize institutions like Columbia Asia Hospital, Cloud9 Hospital Bengaluru. Apart from private practice, Dr. Archana has been constantly in touch with teaching/ training post-graduates in ART & General Gynaecology and Obstetrics. She has successfully treated many infertile couples with all the available techniques of Infertility Management, like IUI, IVF, ICSI, etc. Being friendly, practical, reassuring she has won many hearts of her patients & is immensely popular inthis area. Needless to say, Mannat’s approach is highly personal, confidential and very intimate and caring. Its highly personal touch and very time- consuming, but the clinic keeps no stone unturned to provide its patients with the most comprehensive solutions. “We are not an IVF (In Vitro Fertilization) factory. In fact, IVF is last option for us. So far we have achieved maximum success in most cases combining healing and coaching sessions with our Allopathy treatment. Even IVF success rate increased phenomenally using these holistic approaches,” quotes Dr.Archana. Distinctive Services and Therapies Mannat is a fertility solution centre. It explores conceiving in a natural manner as the first option. The clinic has previously proven research that human body can come back to normal on its own. It works on Body-Mind- Spirit to detect the cause of one’s infertility beyond biology. Mannat has found that negative emotions or a negative event of a person’s lifecreates biological disorder to cause infertility, these are almost alwaysreversible. With research and treatments to cure people in a natural way, it is an integrated medical centre driven by specialists, who have more than a decade long experience in dealing with infertility. Realizing that infertility is a fairly new concept for many tobelieve, Mannat has worked out a package of 10 hours of the module, for its patients called VEDANA. It allows one not only to experience the peace, which it is talking about, but there are caseswhere a couple conceived within three weeks of completing thispackage. Mannat Fertility Centre firmly believes that PCOS is over-diagnosed condition and most of the couples get benefitjust by correcting and balancing it out. The doctors, working at Mannat, are also well experienced as they have served as the leading positions in some of the top IVF centres nationwide. Mannat has some of the most advancefacilities in the field of IVF technology, thereby, making it the most suitabledestination. In the sector of IVF technology the centre has earned its name mostly due to its top in-house IVF doctors from Bengaluru and India. The services provided by Mannat are world-class, which also provides an edge among other IVF clinics in Bengaluru or India. Awards andAccolades The number of smiling parents and healthy babies that were delivered at Mannat speak leaps and bounds of the success of the centre. Acknowledging this, it has been awarded ‘One of Top Most t IVF Clinic’ in Bengaluru South India Last three years consecutivelyas per Times of India Survey conducted from 2015 onwards in SouthIndia. In case, IVF is to be done, the centre increases the success rate from 35%to more than 50% through its holistic work. It is equipped with the latest technology including ICSI, surgical sperm retrieval, embryo freezing, embryo biopsy, laser assisted hatching and blastocyst transfer, using the best equipment and disposables. Through holistic healing, the centre hasbeen Future Perspective of Mannat Mannat Fertility centre is working towards starting a fertility centre in Malaysia and subsequently expanding across South East Asia. It has recently launched laser Hatching, PGS/PGDas a part of it state-of-the-artfacilities. The Experienced &Judicious Leadership Dr. Archana Agarwal is the Director Infertility, and Consultant Infertility Specialist& |October2018|45

48. A Hope to ConquerInfertility Naturally witha 5P Coin-sizedDevice 5P C O IN

49. A few British scientists have brought hope to numerous infertile couples yearning to have children by developing a tiny device. This device can eliminate the need to turn to the arduous IVF treatment. ThegeniusesattheUniversityofSouthamptoncannowhelpdiagnose thecausesofunexplainedinfertilitywiththeirdevicethatisassmallas a 5p coin. This sensor was devised by Professor Cheong along with a bioelectronics engineer Professor Hywel Morgan. They have established Vivoplex Medical, a Southampton University spin-out company, where they started developing this device. For the clinical trialofthegadget,thestartofwhichisdueinthenextfewmonths,the researchbranchofNHS-NationalInstituteforHealth Researchhasprovidedthemwithof £850,000grant. The DevelopmentTeam About the RevolutionaryDevice The tool helps in monitoring the vital elements that have amajor impact on fertility- temperature, oxygen levels, and pH in a mother’swomb.Itistobeimplantedintheuterusbyadoctorora nurse, just like a contraceptive coil is inserted. The process of implantationmaynottakemorethanafewminutes.Theinserted devicethenmonitorsthewomb’sconditionsforaboutsevendays. Thesensorisconnectedtoanelectronicdevice,sayasmartphone oracomputer.Thedatathatitgathersiswirelesslytransmittedto a small transmitter that is worn on a piece of clothing. This transmitter,inturn,transfersthedatatotheelectronicdevice. O2&H2O PotentialBenefits Myriads of couples around the globe are facing the problem of infertility. Until now, fertility doctors have had no reliable way of investigatingthenaturalconditionsofthewomb-itstemperature, oxygen, and pH factors. With this device, something as small and simple as aspirin can change the conditions of the uterus. “Not only could it give doctors the ability to diagnose fertility issues sooner–andpotentiallyreducetheburdenthatfertilitytreatment brings to our patients – but it also has promising potential to inform the development of new fertility therapies and treatments,”saysProfessorCheong.

50. MedAnsh A Preferred Destination forIVF I ndia is at par with most nations withrespect to technology and advancements in allfields of medicine including AssistedReproduction (ART). The concept of IVF would earlierbe shunned in the Indian society but today it has gained popularity at a swift pace. Families areno longer shying from going to an IVF centre to achieve their dream ofparenthood. The demand for IVF has steadily increased over the years. Factors such as late pregnancies, altered lifestyle, dual income families and changing preferences are the key reasons due to which the problem of infertility in the countryis increasing at an alarming rate. Owing to the sensitive nature of the IVF treatment, couples prefer to survey all options before they embark upon the IVF journey at a centre theytrust. MedAnsh Multispeciality Hospital is onesuch centre that has received rave reviews in the field of infertility for providing good quality service. Situated in Mulund, Mumbai it is a luxurious hospital focused on healthcare needs ofwomen. Dr. Shrutika Thakkar Obstetrician-Gynaecologist& FounderDirector A perfect blend of technology and human touch, MedAnsh is ready to support women throughout their journey of life. The hospital has beenstarted with a vision of providing excellent international quality treatment at affordable rates. The MedAnsh team believes in providing a holistic treatment to the patient. The panel of doctors at MedAnsh consists of a gynaecologists, IVF specialist, embryologists, andrologists, endoscopic surgeons, counsellors, dieticians and physiotherapists who understand the kind of care and efficiency required to assist a woman- whether it is an IVF treatment she is seeking or a fibroid removalsurgery. We have the bestof IVF technology atour disposal, we are better at solving and diagnosing problems for infertilecouples 48| October 2018|