Top 5 Healthcare Packaging Companies 2023

1. June ISSUE 01 2023 Top 2023 Advancing Patient Care Innovations in Healthcare Packaging Protecting Integrity and Trust The Role of Tamper-Evident Packaging in Healthcare Andreas Bilstein Managing Director URSATEC GmbH

2. Helping Technology Work With You & For You Technology Technology For You For You

4. Ed tor’ s Note

5. Recognizing Packaging Excellence in Healthcare ealthcare packaging plays a vital role in ensuring H throughout their journey from manufacturing to end-users. It serves as a crucial protective barrier, safeguarding the contents from potential damage, contamination, or tampering. The companies featured in this edition have gone above and beyond in meeting the evolving needs of the industry, setting new standards, and driving advancements in healthcare packaging. We applaud the featured companies for their outstanding achievements and unwavering dedication to excellence in healthcare packaging. Their contributions continue to shape the industry and have a positive impact on the healthcare ecosystem as a whole. the integrity and safety of medical devices, pharmaceuticals, and other healthcare products We hope that this edition provides valuable insights into the advancements and innovations shaping the healthcare packaging landscape. We invite you to explore the profiles of these leading companies and learn more about how they are revolutionizing the future of healthcare packaging. Our selection process carefully considered various factors, such as product portfolio, technological advancements, industry reputation, customer satisfaction, and overall impact. The chosen companies have consistently displayed a commitment to excellence and have pushed the boundaries of innovation to deliver exceptional packaging solutions. Thank you for joining us on this journey as we celebrate the remarkable achievements of the Top 5 Healthcare Packaging Companies in 2023 and their invaluable contributions to the healthcare industry. Have a thoughtful read! -Pooja Shah Pja Sh This edition features companies that have excelled in areas such as state-of-the-art manufacturing facilities, sustainable packaging initiatives, cutting-edge technologies, sterile and aseptic packaging expertise, and patient-centric packaging solutions. These companies have made significant contributions to the healthcare packaging landscape, ensuring the safe and secure delivery of healthcare products worldwide.

6. Cover Story 08 URSATEC GmbH Aiming for a Preservative free Future Ctts Ctts

7. 16 32 DaklaPack Group Empowering Packaging Solutions for a Sustainable Future Teampac Oy A Partner in Manufacturing Cleaning and Disinfectant Products from Idea to End 24 How AI is changing the Landscape of Neuroscience 28 20 Aicl Advancing Patient Care Protecting Integrity and Trust The Role of Tamper-Evident Packaging in Healthcare Innovations in Healthcare Packaging

8. Editor-in-Chief Chidiebere Moses Ogbodo Managing Editor Pooja Shah Executive Editor Saloni Agarwal Visualiser David King Art & Design Head Mrunalinee Deshmukh Co-designer Paul Belin Art & Picture Editor Deepanjali Jena Business Development Manager Emily Jones Marketing Manager Bill Thompson Business Development Executives Anna Smith, Jack Miller Sales Executives Mike, Carl, John Technical Consultants David, Robert Assistant Technical Head Prashanth Hiremath Technical Head Jacob Smile Digital Marketing Manager Alina Sege Assistant Digital Marketing Manager Sagar Lahigade SME-SMO Executives Gemson Research Analyst Eric Smith Circulation Manager Tanaji Fartade sales@insightscare.com June, 2023 Contact Us: Insights Success Media and Technology Pvt. Ltd. Survey No.133/134, Brand Square, Office No. 512, Kunjir Chowk, Pimple Saudagar, Pune, Maharashtra 411027. Phone - India: 7410033802, 8956487823 Email: info@insightscare.com For Subscription: www.insightscare.com Insights Success Media Tech LLC 555 Metro Place North, Suite 100, Dublin, OH 43017, United States Phone - +1614-602-4132 Email: info@insightscare.com For Subscription: www.insightscare.com https://twitter.com/Insightscare Follow us on : www.facebook.com/InsightsCare/ We are also available on : Copyright © 2023 Insights Success Media and Technology Pvt. Ltd., All rights reserved. The content and images used in this magazine should not be reproduced or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from Insights success. Reprint rights remain solely with Insights Success Media and Technology Pvt. Ltd. Insights Care is powered by Insights Success Media and Technology Pvt. Ltd.

9. Top 2023 Featuring Person Company Name Description Daklapack Group are the market leader in innovative green packaging and shipping materials. Dave Klaassen CEO DAKLAPACK GROUP daklapack.eu Sealed Air is in business to protect, to solve critical packaging challenges and to make the world better than we find it. Ted Doheny CEO Sealed Air sealedair.com Teampac Oy is a contract manufacturer of medical devices and healthcare, cosmetics and hygiene products. Teampac Oy teampac.fi Jyri Temonen CEO Thoro Packaging is a sustainable packaging manufacturer based in Southern California, close to the Los Angeles Metropolitan Area. Thoro Packaging thoropackaging.com Jan Steiner CEO URSATEC GmbH provide innovative primary packaging materials and combine in-depth development with approval know-how and high-quality contract manufacturing. Andreas Bilstein Managing Director URSATEC GmbH ursatec.com

10. Top 5 Healthcare Packaging Companies 2023 URSATEC Aiming for a Preservative- free Future “ The company's mission is to spread this technology and understand the need for preservative-free products even further, so more people can profit from its technological advantages.

11. Andreas Bilstein Managing Director URSATEC GmbH

12. I When Preservative-free Matters n the pharmaceutical industry, the medicines are kept free from microbial contamination by adding preservatives to prevent the degradation of products and avoid the spread of harmful microbes. But unfortunately, most preservatives harm the tissue of the body and exacerbate potential preexisting allergies and diseases. URSATEC GmbH is the inventor and market leader in dosage systems for preservative-free applications. 'When preservative-free matters' is more than just a slogan for the company; it focuses on its actions and its commitment to its product and service portfolio. Considering these challenges, there are organizations that have a futuristic approach and are producing preservative- free products. One such company, URSATEC GmbH, supports the global health industry by providing, developing and approving preservative-free products. It is well-known that preservatives can cause various allergic reactions such as allergic rhinitis, atopic dermatitis, or contact dermatitis. The organization supports the global healthcare industry in developing, approving and producing preservative-free pharmaceutical, medical and cosmetic products as well as food supplements. Andreas Bilstein, Ph.D is the Managing Director of the company since August 2020. He is a biologist by training and has more than 15 years of experience in developing medical devices, food supplements and cosmetics. He has always focused on preservative-free products for various applications and indication areas. Wide Range of Preservative-free Products URSATEC's main cooperation partners and clients are pharmaceutical, medical device and cosmetics companies, and offer their customers safe and effective solutions with their products and trust in the quality – made in Germany. What drives him is the development of advanced products and a better life for people, combining data-driven scientific research and economic impacts to achieve innovation and progress. The technologically sophisticated systems are made to protect unpreserved formulations for long-term use. What began as a niche product has risen to a 25-year lasting success story. Andreas believes for everyone starting in this industry in today’s day and age, the organization highly recommends keeping innovation and progress as core principles of every new venture. The dosage systems guarantee perfect protection against microbial contamination while providing all the advantages of multi-dose systems. They offer safety of use without the need for any preservatives. The organization is proud to have initiated a rethinking of the market for nasal sprays and set preservative-free formulations as the new standard in Europe. URSATEC is continuously aiming to improve the dosing systems and their materials used for improving sustainability and quality. The company extends the existing technology by implementing solutions not only for liquids but also for semi-solid applications to allow the development of truly preservative-free emulsions and lotions for skin treatment. They are also working on optimizing droplet size distribution and application performance to allow targeted delivery, e.g. for the olfactory region or lung delivery. Together with partners, URSATEC works on the digital augmentation of the pump systems to allow telemedicine

13. Inculcation of Technological Know-how approaches, dosing control, filling control, and connectivity approaches between the users and the health care professionals. New technologies are fast forward at a pace that was not imaginable before. Especially social networks are booming, and therefore more opinion- leaders now support the healthcare professionals. With their influence on consumers, they can quickly lead them towards a certain trend or product, with consumers following them willingly. Adhering to Core Values Since the core value of URSATEC is to support the growth of preservative-free products to support the world´s healthcare industry, Andreas and the company's focus is based on making healthy and tolerable products suitable for every age and every need. As it is the company's responsibility for planning and producing industry scale quantities for global players of the pharmaceutical branch, URSATEC, of course, relies on the latest IT technologies for their ERP systems, internal- and external communication tools, as well as documents storage and exchange. Andreas further states, "Especially people with allergies or sensitive skin often must be extra careful when choosing cosmetics, food supplements or healthcare products. With our 100% preservative-free technology, we can exclude almost all allergic reactions and hence provide healthy products for everyone." Besides the digital improvement of its operational side of the business, the organization also entered the topic of digital augmentation to allow enhancement of the customer's experience of drugs and devices. Accordingly, the company's mission is to spread this technology and understanding the need for preservative-free products even further, so more people can profit from its technological advantages. With Validose, the organization is working on a digital augmentation of its container closure system, to enable

14. already consumed in a day. All this information is then shared with the physician and can be evaluated without additional in- person appointments. Probably the biggest challenge every industry and every company is facing in 2022, is keeping up the supply chain and the flexibility to adjust to the rapidly changing economic environments of the company and its customers. That means developing smart storage and delivery concepts in cooperation with customers and suppliers, rather than taking a solo approach to solution-finding. With such smart concepts on storage keeping, forecasting, and delivery optimization, Andreas asserts, "we will also be able to increase customer demand as they will also gain security in their planning and supply chain management." telemedicine approaches, better patient control, and application and hence overall more convenience in using the product. One-Stop Solution The Latest Adversities Increasing the customer's demand also provides a chance for the organization to further establish its ONE Source concept and brand. ONE Source is the way to fulfill customers' expectations and provide the complete value chain of a product. Starting from the idea of providing innovative dosage systems, full regulatory support, and laboratory services up to sterile filling and thus providing the customers with filled and finished products from just one single point of contact. The innovative device allows the digital connection of patient and attending physician via apps and prevents false or even overuse of the prescribed drug by tracking the prescribed dosage and correlating it with the amount The technologically sophisticated systems are made to protect unpreserved formulations for long-term use.” An Intellect's Piece of Advice Andreas believes for everyone starting in this industry in today's day and age, that keeping innovation and progress as core principles of every new venture are absolutely essential. He further opines, "Entrepreneurs need to be open-minded on new opportunities and technologies and hence should be keen to take a more data-driven approach to solution finding and scaling their business."

15. Since regulations and quality are cornerstones of the industry, they need to be professionally implemented instead sooner than later and thoroughly connected to modern IT systems, not only in a company itself but also with other ventures to achieve maximum impact. Besides this, Andreas asserts staying calm and patient. He states, "We are dealing with people´s health, so all risks and safety measures must be evaluated in-depth, and there is no space for rushing decisions and developments. Quality, especially in the pharmaceutical industry, needs time for the end consumer's benefit." Futuristic Approach When talking about the further endeavors of URSATEC, Andreas asserts that the year 2022 has yet been another year facing a global pandemic and other challenges around the world. So, of course, its goal is to provide beneficial products to a wide range of people and make them accessible to as many people as possible. Further talking about COVID, Andreas states, "If there is one thing, we can take out of the COVID pandemic, it is the convenience and scalability via virtual meetings and new work in general. Those new digital tools will be used by URSATEC even well after the pandemic is over, to provide convenient access for our customers and partners and to enable soaring efficiency of our internal processes and projects." To do so and ultimately scale their business, the company strongly focuses on finding new partnerships and partnering companies with whom they can launch innovative products. URSATEC's Business Development is working with different online channels and digital events, as well as with conventional trade shows to be present in the market and to find new partners. Apart from that, the company keeps a close eye on the market, the developments and trends in the pharmaceutical, cosmetic and food supplement markets, and hence they have always stayed on top of the current market needs.

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18. Top 5 Healthcare Packaging Companies 2023 DaklaPack Group Empowering Packaging Solutions for a Sustainable Future I medications become more diverse and specialized, there is a growing demand for packaging that not only ensures product integrity and safety but is also Eco-friendly and minimizes environmental impact. Recognizing this crucial need, DaklaPack Group has emerged as a leading force in providing innovative packaging solutions tailored to the unique requirements of healthcare clients. n the ever-evolving healthcare industry, the need for sustainable and customized packaging solutions has become paramount. As healthcare products and In an era where sustainable and customized packaging is pivotal to the success of healthcare companies, DaklaPack Group stands as a trusted partner, dedicated to meeting the evolving needs of the industry. Through its unwavering commitment to sustainability and client satisfaction, DaklaPack continues to redefine the standards of healthcare packaging, ensuring that products are protected, the environment is respected, and client's expectations are surpassed. Let's dive in to learn about DaklaPack’s innovative operations in empowering flexible packaging products and staying at the forefront of the packaging industry. DaklaPack's unwavering dedication to meeting client needs is deeply rooted in its commitment to innovation. By investing in cutting-edge technology and adopting environmentally responsible practices, the company ensures that its packaging solutions not only safeguard healthcare products but also reduce waste and carbon footprint. DaklaPack Group in Brief The DaklaPack Group, founded in 1975, is a Netherlands- based company that specializes in packaging and packaging solutions. It primarily serves the food, medical, pharmaceutical and chemical industries. The company initially started as a small-scale distributor of plastic bags, but over the years, it has expanded its product offerings to include a wide range of packaging materials, medical shipping solutions, (medical) kitting and services. Additionally, DaklaPack understands that each client in the healthcare industry has distinct packaging requirements. From assisting them in the (technical) design of their collection kit to the procurement of materials, the company recognizes the importance of delivering customized solutions that precisely meet the specific needs of every client. By nurturing long-term relationships, DaklaPack collaborates closely with its clients, gaining invaluable insights into their unique challenges and goals. This collaborative approach enables DaklaPack to develop tailor- made packaging solutions that enhance product safety, efficiency and brand representation. DaklaPack's mission revolves around providing innovative, high-quality packaging solutions tailored to clients' specific needs. It focuses on delivering exceptional customer service, fostering long-term relationships, and continuously investing in research and development to stay at the forefront of the packaging industry. Under the leadership of Dave Klaassen, the CEO, DaklaPack has grown its global presence and subsidiaries in Europe, Asia and the United States, serving healthcare clients on an international scale. The company's extensive network and vast expertise allow for seamless collaboration and efficient delivery of packaging solutions, regardless of geographical location. The DaklaPack Group operates internationally, with several subsidiaries in Europe, Asia and the United States. DaklaPack is committed to sustainability and environmental responsibility, which is reflected in the team's efforts to minimize waste and reduce its carbon footprint. 16| June 2023|www.insightscare.com

19. Climbing the Ladder DaklaPack's transition into the healthcare field was driven by several innovations and patented products that the team developed in the early 2010s. The company's Rigid Safety Bag, which combines a leakproof bag with absorption material and a rigid layer, allows for medical specimens to be shipped via the postal and parcel networks inside of a small flexible mailer instead of the traditional cardboard box. This makes that specimen can be shipped more cost- effective, easier and safer. Dave Klaassen CEO In addition, the packaging solution can be easily and quickly opened by the receiver (often medical laboratories). "It were innovations like these that drove us into the medical field, and primarily the at-home specimen collection market. Our core business changed from packaging supplies to medical kitting and 3PL services," adds Klaassen. Packaging Products and Solutions From the start we apply a consultative approach, enabling our customers to utilize our vast experience and know-how in the design of their products and processes. We typically have several brainstorming sessions with our clients after which our team produced several samples of the various kit concepts our customers are interested in. Once a final design has been determined we work out a quotation, which typically includes all related costs to having these kits made, stored and shipped. DaklaPack specializes in high-quality packaging products and solutions for various industries, primarily in the medical field, food packaging and industrial packaging. Its focus in the food and industrial fields is on niche products, often the more technical solutions. "For example, we have developed a disposable bioreactor that is currently used in potato cultivation. These type of projects is what we specialize in," says Klaassen. He continues, "Over the years our medical business has grown substantially and we run some of the largest medical kitting projects globally, such as the French and the Dutch population-wide colon cancer screening programs. In the past years, we have shifted our focus more and more toward medical kitting and we offer a wide range of related services." "For most of our kitting clients, we assist in the (technical) design of their collection kit and the procurement of materials. We can assemble kits on three continents and provide warehousing and order fulfillment services. In Europe, we also operate a medical laboratory, which can be leveraged by our kitting customers who want to expand their operations into Europe." Production Process at DaklaPack "The details of the production process differ for each market we operate in, but if we focus on the medical kitting 17| June 2023|www.insightscare.com

20. segment, we apply a hybrid project management method. We have seen this is the most effective approach to managing the complexity of kitting projects, which includes various process flows," explains Klaassen. "From the start we apply a consultative approach, enabling our customers to utilize our vast experience and know-how in the design of their products and processes. We typically have several brainstorming sessions with our clients after which our team produced several samples of the various kit concepts our customers are interested in. Once a final design has been determined we work out a quotation, which typically includes all related costs to having these kits made, stored and shipped." He continues, "After the order is placed, we procure and produce all required components and schedule kit assembly. Simultaneously our IT team helps to enable our customers to integrate with our ordering systems, through APIs or web portals. Once the first kits have been assembled and shipped, we usually enter an ongoing process in which we keep in close contact with our customer to ensure operations run smoothly and as expected." Attaining International Standards DaklaPack has its facilities and procedures certified to international standards such as ISO9001; ISO27001; FSSC22000 and is in the process of obtaining ISO13485 certification on its US and European facilities. Setting Apart from Others in the Market DaklaPack differentiates itself from other healthcare packaging companies through a strong commitment to sustainability, customization, advanced technology, regulatory compliance and exceptional customer service. The company prioritizes eco-friendly packaging solutions, using recycled materials and minimizing waste throughout production. Its design team collaborates with clients to create unique, tailored packaging that meets their specific needs. It invests in cutting-edge technologies to optimize production processes and enhance product capabilities. "Our experts stay up-to-date on industry regulations, ensuring compliance with applicable laws and guidelines. With dedicated account managers, we offer personalized, responsive service, fostering smooth communication throughout the entire project life cycle. These core values set us apart and deliver unparalleled value to our clients in the healthcare industry," adds Klaassen. 18| June 2023|www.insightscare.com

21. Overcoming Challenges For DaklaPack. the biggest challenge by far is to keep healthcare affordable and accessible. "Our goal is to help our customers to provide safe, efficient and affordable at- home self-sampling diagnostics tests. At-home sample collection takes away barriers and allows people to get tested whenever it best suits their schedule, in the safety of their home. As there is no need for medical professionals to be involved with the specimen collection this also reduces the overall costs of diagnostic tests," emphasizes Klaassen. In the medical packaging field, sustainability also presents challenges. Safe and robust packaging and sustainability can be tricky to balance, especially in the medical field. When compared to the food and industrial sectors changes usually take much longer in the medical field as changes need to be thoroughly validated before being put into effect. "To move to a more sustainable way to pack sterile medical products and at the same time not negatively affect the properties of the product, while keeping the costs down as much as possible will be a big challenge for the coming years," he adds. Client Testimonial "DaklaPack is a steadfastly reliable and trustworthy strategic partner. We discovered DaklaPack in mid-2019 while sourcing kitting components. During that introductory meeting, Sander and the team proactively shared invaluable kitting, sample tracking and fulfillment advice! That left an indelible, positive impression, leading to our formalizing a multi-year supplier relationship in Dec. 2019. DaklaPack has a collaborative, agile business culture and a devotion to operational precision and service excellence. They have invested considerable time and resources to ensure our success in crucial ways, including JIT (just-in-time) B2C single unit and B2B case kitting, API order/fulfillment data integration, cutting-edge kit and sample tracking, cost-effective component sourcing, and next-generation technology buildouts; all of which are scale-ready. As importantly, Sander and the team are always friendly, supportive, and rapidly responsive which says a lot given our small company size. As I think back over the last two years building MySimplePetLab, partnering with DaklaPack is one of our best decisions and we remain truly grateful to have their ongoing business and thought partnership." 19| June 2023|www.insightscare.com

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23. Advancing Patient Care Innovations in Healthcare Packaging E mbracing change might be strenuous but the needful thing to carry out for the betterment of business scenarios. Healthcare is one of the fastest growing sectors and with a new day, emerging innovations can revolutionize the sector. Innovative medical products and pharmaceuticals are becoming a change factor and these novel products require complex packaging. This approach has far-reaching effects and without implementing this, companies will be pushed backward in the race of change. As stated by Steve Jobs, "Packaging can be theatre, it can create a story," continuous innovation in healthcare packaging is making a big impact on the healthcare market. While innovative and unique packaging solutions are around the corner, companies must acknowledge their significance and implement them for better patient care. Above all, creating patient-centric, innovative and flexible packaging solutions will consequently influence the role of consumers and we must think beyond that for better brand awareness and optimum patient care. 21| June 2023|www.insightscare.com

24. solutions to resolve the issues faced by the supply chain in healthcare. They include errors at shipping and receiving ends, inefficient processes, etc. To deal with this, smart label solutions help in shipment verification, backend integration, removal of human error, following local and global legislation rules, and improving supply chain visibility. Let's dive into the ocean of innovative ways to package solutions: Changed Packaging Intense demands to make packaging better have initiated the process of easy-to-use and disposable packaging solutions. Earlier, packaging was an afterthought and it served only as a means to contain and protect the medicine. Now, responding to the new materials and delivery mechanisms, companies are focusing on changing the packaging according to the odds it faces including temperature fluctuations, vibration, tearing, shock, etc. Not just this, the packaging must handle the whole process of handling, shipping, transportation, and usage. An easy example of smart-label solutions is QR codes. Through this, the product can be tracked, and the authenticity can be verified. Additionally, in common usage, smart labels used today are RFIDs, Near Field Communication (NFC) tags, etc. The RFID labels ensured an added level of security and safety for the patients in the hospital. Apart from these solutions, Smart Cabinets are used along with the RFIDs. These systems keep a real-time inventory count, and it gets easier to work on re-ordering products and managing expired and recalled products. A smart and sustainable packaging system is beneficial, and it affects the behavior of customers as well as brand loyalty. And of course, there is a direct correlation between the packaging, usage experience and overall engagement. Hence, solutions come with easy-to-open and flexible blister packaging. Manufacturing companies tend to use new thermoplastic polymers by driving change in the traditional packaging systems. Child-Resistant Packaging Also known as 'Special-packaging', child-resistant (C-R) packaging is essential for reducing the risk of children getting poisoned due to the leakage of medicine. Track and Trace Technology Additionally, it now demands that customers make the C-R packaging senior-friendly also. According to a survey, customers are ready to buy the products if the packaging is safe and it protects them from hazardous substances. While the outer part of the medicine packaging is blended with innovative technology, the end-to-end supply chain process also needs protective covering in terms of security. It is the responsibility of the leader of the company to ensure the safety of the medicine, making the delivery secure. Here come modern electronics in the picture wherein smart track and trace technology is used. Such packaging is difficult to open and in general, the packaging is accompanied by a safety cap. Prescription drugs, drugs that are sold over the counter, opioids, and nicotine-containing consumables commonly come in such packaging. Child-resistant packaging comes in various ways including blister packaging, sprays, caps and closures, resistant sliders, re-closable CR cartons, lock4kids, etc. These solutions can be embedded into the packaging of the medicine and with the control handed over to the leader, especially CEOs, manufacturing and distribution risks can be minimized. Such difficulties include temperature changes, wrong deliveries, counterfeit products, etc. Track and Trace solution helps CEOs in monitoring the products and mitigating the risk of counterfeit products. With every industry changing and adopting innovations, the healthcare sector is on the verge of implementing and bringing innovations to the table. The latest packaging innovations are now in the pipeline, and they are enhancing patient care. However, cost-effective and business-positive solutions are the future of the healthcare industry. The Use of Smart-Label Solutions While the system is incorporating track and trace techniques, smart-label solutions are the next-generation - Saloni Agarwal 22| June 2023|www.insightscare.com

26. How AI is Changing the Landscape of Neuroscience T not only grown as an industry itself but has boosted developments in numerous other fields as well. One such modern discipline of technology that opened a floodgate of opportunities is artificial intelligence. echnology compounds. With advances in new techniques, varied applications, and optimization of multiple processes and operations, technology has brain. Therefore, as AI technology compounds, so can neuroscientific findings and approaches. As a tool, AI aids neuroscience in two distinct ways. First is the technical aspect, where techniques like machine learning can analyze complex data from the brain to recognize patterns that can then be given meaning. As human beings, our biggest inspirations have been characteristics of ours, like kindness, perseverance, and so on. Similarly, we have been inspired by the intelligence, so much so that we are trying to replicate its concept in the form of technology. By understanding the cognitive and neuroscientific processes behind intelligence and computing them, we have been able to advance the field of artificial intelligence with applications in a number of areas, as well as newer approaches to data conceptualization & analysis, machine learning, and robotics. The second aspect is algorithms that hugely evolve brain- like outcomes and become focal points to examine basic and underlying ideas in neuroscience. For example, artificial neural networks, which were developed by mimicking human neural connectivity and functionality, are now being used to capture representations of the dynamics of the brain. Such functions are then used in a targeted manner to delve deeper into the prospects offered by neuroscience. Let's take a moment to reflect on many of these possibilities that have been explored so far, yielding extraordinary results. The debate on the involvement of the medial temporal lobe (MTL) only in memory-related behaviors versus in the function of memory as well as the perception was long-standing. But work by Bonnen, Yamins & Wagner used a novel computational framework for addressing this Coming full circle, advancements in AI have played a major role in the growth of neuroscience as a discipline of research and application. Advanced AI systems can help drive neuroscience forward to unlock the neurobiological secrets of the brain. Basically, it allows neuroscientists and researchers to build better models to simulate the human 24| June 2023|www.insightscare.com

27. About the Author The Co-founder and CEO of BrainSightAI, Laina Emmanuel, has 15 years of experience in healthcare management, policy and consulting. She has an MBA in healthcare from ISB and has used her learnings in consulting for the Government of India and some of the highest impact organizations like Clinton Health Access Initiative. She also has the deep technical knowledge, having worked in product teams building products affecting millions of people at Netapp and the offshore development center of Cisco at Infosys. Laina was also one of the two Indian start-up founders selected by Google for its Women Founders Academy and featured in Forbes magazine W Power List (2021). problem, where task-optimized Convolutional Neural Networks (CNNs) were applied to disentangle the relationship between perception and memory within the human brain. Speaking of novel tools from AI that can broaden and formalize our understanding of neural function, another interesting use of such techniques has been demonstrated by biomedical engineer Chethan Pandarinath from the Georgia Institute of Technology. To enable people with paralyzed limbs to reach out and grasp with a robotic arm as naturally as possible, he turned to AI. While the results did show perceptual behaviors, what's more, important is going beyond the debate and focusing on the use of technology here. The modeling approach used was faced with solving the same problem that has so far only been presented to people. But as Bonnen puts it - "Biologically plausible AI computational methods can help us understand neural systems beyond canonical visual cortices." He fed brain-activity recordings to an artificial neural network and tasked it with learning how to reproduce the data. The effort revealed the brain's temporal dynamics — the way that its pattern of neural activity changes from one moment to the next — thereby providing a more fine- grained set of instructions for arm movement than shown by previous methods. 25| June 2023|www.insightscare.com

28. The future of AI and neuroscience is even more exciting. Recent efforts to understand and reverse engineer the brain's ventral visual stream, a series of interconnected cortical nuclei responsible for hierarchical processing and encoding of images into explicit neural representations, have shown great promise in the creation of robust AI systems capable of decoding and interpreting human visual processing, as well as performing complex visual intelligence skills including image recognition, motion detection and object tracking. About BrainSightAI BrainSightAI is a deep tech neuroinformatics platform for connectomic analysis. Thor product, VoxelBox, helps neurosurgeons preplan neurosurgery by accelerating pre-processing multiple scans like sMRI, rsfMRI, fMRI, and DTI within 60 minutes. BrainSightAI has been supported by 3 Fortune 500 companies- Dassault Systemes, GE, and NetApp. They have won the India-Sweden Healthcare Innovation Challenge, featured in the top 20 of the MedTech Innovator Challenge, selected for P4 Precision Medicine Incubator. They are in the Google for Startups Accelerator (cohort 6) and supported by Microsoft and Accenture joint- venture for startups known as Project Amplify. Neurocognitive robotics is another up-and-coming field, which, as talked about above in the research by Pandarinath, can revolutionize exoskeletons and robotic surgeries with the help of transfer learning techniques. Apart from this, big neuroscience datasets have managed to automate a major part of neuroscientific research. For instance, fMRI generates snapshots of activity throughout the brain at a resolution of 1–2 millimeters every second or so, potentially for hours. Wading through such vast amounts of data is now much smarter, and hence, neuroscientists can focus on what the insights show rather than how to generate them. AI models can be used to map the various neuron-to-neuron connections in the body with quite a bit of accuracy, known as connectomics. The whole brain - with its pathways and these neural connections makes up the connectome, and it is believed that this is what makes you, you. If one's connectome can be mapped and modeled entirely, then this data could ideally emulate a person's whole brain. This connectome-based brain emulation has the potential to provide novel solutions for many problems related to brain miswirings, for example, neurodevelopmental and neuropsychiatric conditions like autism and schizophrenia, respectively. Furthermore, it can also help in predicting behaviors, the prognosis of disorders, and calibrating neuroplasticity. The aforementioned examples are only two out of the thousands of studies and applications that have been carried out, driven by the intersection of AI and neuroscience. This relationship has also facilitated massive developments in improving the scope of medical imaging and diagnostics with superior data capturing and pattern recognition. In keeping with this, the potential to compute brain structures and functions, such as neurotransmitter pathways of white matter lesions, can greatly aid neurology and psychiatry. AI and deep learning can help optimize different brain structures and carve pathways to treatment by enhancing the understanding of neural impulses relayed from and within the brain. Creating virtual 3D brain structures has also become possible, and this can give an impetus to further research and discoveries in neuroscience, along with fostering a new environment for medical training. The symbiotic relationship between AI and Neuroscience is characterized by the magnitude of impact both disciplines have on each other. In the future, the synergy between the two should be expected to increase incrementally. The challenge for AI experts, neuroscientists and healthcare personnel will be to establish the right level of translational ability between the fields. 26| June 2023|www.insightscare.com

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31. I t is necessary to analyze the products the pharmaceuticals sell must reach the right patient and there should not be unauthorized access to such drugs to avoid accidents. To ensure the intended use of the packing, companies come up with the solution of tamper- evident packaging for products that are likely to endanger the lives of people. In general, the packaging comes with seals, tapes, markings, strips, etc. Along with that, it is also advised not to use an already opened medicine as it is not trustworthy to have an intake of the same. Before visiting the advantages of tamper-evident packaged products, let's know exactly what is the concept and its significance. What is tamper-evident packaging? Also known as tamper-resistant packaging, this type of packaging is a must-have thing for over-the-counter (OTC) drugs. According to the definition by Food and Drug 29| June 2023|www.insightscare.com

32. Tamper-evident Tapes: These are the most commonly used types for tamper-evident packaging. They are efficient in protecting products and preventing tampering during shipping and delivering the products. They are applied on Corrugated, metal and plastic surfaces. They have a highly-visible 'VOID' or 'OPENED' message and we can clearly see the carbon has been opened when tampered with. The tape cannot be reused without leaving any evidence and thus, is regularly used in pharmaceutical industries. After the deadly pandemic, this scenario has changed and most manufacturers, retailers, food delivery services and wholesalers have started using the tapes for a safe supply chain. Administration, 'A tamper-evident package is one having one or more indicators or barriers to entry which, if breached or missing, can reasonably be expected to provide visible evidence to consumers that tampering has occurred.' Ÿ The sole use of tamper-evident packaging is to recognize whether the sealed product has been opened or not. Once tampered with, the package cannot be repaired and it's strictly advised to customers to avoid the use of contents of the same. Moreover, it is also necessary to be 'distinctive by design' which indicates that the tamper-evident products must use materials that are not widely accessible to the general public. The reason behind this approach is to avoid making duplicate products and sealings. Tamper-resistant Cartons: A higher level of security is provided by tamper-resistant cartons. This type makes it difficult to access the packaging without causing any damage. Especially, if it leaves marks or trails of tampering on the product packaging. Tamper-resistant cartons are specially designed to stop someone from opening the contents of the product. As stated, it is difficult and time-consuming to open such products, thus ensuring safety. This is a well-liked remedy in the pharmaceutical and healthcare sectors for reducing the dangers of consuming tampered-with goods. As open seals or cut lids provide clear proof of used products, manufacturers can ensure that there remains good evidence. This way, they can secure their products and avoid theft, fraud or other compromises also. The second advantage of a temper-applied packaging is that people can't remove, alter or damage the product. The most important thing is whomsoever is using the product, the packaging must include information regarding the usage of the same. In particular, it must have a clearly visible seal and detailed operating instructions so that the person is fully aware of telltale signs of a tamper-evident product. Ÿ Features of a tamper-evident Product Benefits of Tamper-evident Packaging A tamper-evident product alerts consumers to save from foul play or damaging of the same. When a packaging product has been tampered with or opened, tamper-resistant packaging is intended to reveal the evidence. This means that it frequently checks the following things: whether the product is single-use and non-repairable or not. Moreover, it shows signs of tampering and with this, manufacturers remain tension free as it is the best protection for products. Additionally, the packaging also takes care of child- resistant features to prevent unintentional consumption. In general, tamper-evident packaging ensures the safety of pharmaceutical products and the right people receive the right care with the right pharmaceutical products. Moreover, companies and service providers in the pharmaceutical and healthcare sector need to tackle these challenges, especially in the scenario of fake products. When it comes to consumers, it is a threat for them to receive a falsified product and use of such products might be hazardous. Companies have to combat this situation and deal with tampered products. Tamper-evident packaging is a robust and efficient solution for the protection of patients. And of course, it creates awareness among patients and relatives to point out the errors that might be dangerous. Types of Tamper-evident Packaging Tamper-proof packaging comes in a variety of forms, however, the right packaging is created according to the unique requirements and regulations of the particular industry and the products being sold. It is crucial to find the ideal balance between creating a package that helps avoid tampering with products and offering the same product to customers that they can easily open and use. Some of the popular packaging types are as follows: - Saloni Agarwal 30| June 2023|www.insightscare.com

34. Jyri Temonen CEO Teampac Oy 32| June 2023|www.insightscare.com

35. Top 5 Healthcare Packaging Companies 2023 Teampac Oy A Partner in Manufacturing Cleaning and Disinfectant Products from Idea to End T efficient in their result but also possess a promising factor in ensuring the mitigation of Occupationally Acquired Infections(OAI). he rising health uncertainties of contemporary times demands solutions that are not only express a sigh of relief with a blossoming smile. Spearheading this transformative wheel in the health hygiene segment is its CEO – Jyri Temonen. He joined the team in 2020 and starting his journey from Henley Business School to the CEO of Teampac Oy, he has helped many businesses turn around and led people in changing the industry ecosystem. Through his expertise in brand management and sales, he has enhanced the quality of Teampac's production and has led to an almost 100 percent delivery reliability guarantee to its customers, which has established Teampac as a very stable and reliable partner. This can be well understood by the latest research report conducted in the United States of America, which says, “In the USA, as high as 19% of patients had been identified as healthcare workers.” Through the interview highlights below, let us know more about Teampac's dedication to quality and customer satisfaction in the healthcare sector through its expertise in concept management! Having a deep toll on the health of care professionals, OAI contributes to a high threat to care workers' health. This needs to be resolved with enhanced compliance. And the best practice that can ensure the prevention of such hazards is efficient hygiene practices. To solve this crisis that has been prevailing in the healthcare community, Teampac Oy has been safeguarding care workers with its quality products like liquid-based products as well as cleaning and disinfecting wet wipes. Adding up, the company also serves lotions, intimate gels, lubricants, kinds of toothpaste, shampoos, and ultrasound gels in tubes, bottles, and jars. And its specialized medical devices are a true game changer. Teampac’s vision is to be the leading contract manufacturer of healthcare products in Northern Europe. The goal is tough, but at the same time we know that we are heading in the right direction. This Finnish manufacturer has a rich industrial experience of 50 years, delivering high quality and assuring the community with its dedicated services. Teampac Oy adheres to quality and regulatory provisions while delivering its valued clients in the healthcare, hygiene and cosmetics product line while transforming the medical device equipment industry, making the healthcare world 33| June 2023|www.insightscare.com

36. Bringing Experience into Play – CEO, Jyri Temonen Jyri Temonen, CEO, came to Teampac in 2020. He has more than 20 years of experience in the field of techno chemistry. He has been working mainly in Finland but ran some projects in Sweden, Russia and Baltic countries. He has also worked in management positions for over the last 20 years. Teampac's personnel is committed and the average length of service in the company is more than 10 years. They constantly invest in competence development, especially in the healthcare sector where regulatory requirements are constantly increasing (e.g., with the new MDR). As, the CEO, he trusts that Teampac's expert organization can help and support customers also in matters related to regulation. Please brief about Teampac Oy, its USPs, and what has helped position it as a reliable name in healthcare. Teampac is a Finnish healthcare contract manufacturer operating in the international market. We have more than fifty years of experience in developing and manufacturing various liquid-based products as well as cleaning and disinfecting wet wipes for healthcare, hygiene and cosmetics operators. We employ 60 professionals, and our turnover is approximately 15 million euros. At Teampac, the quality of our work comes from the contribution of each of our employees. Quality must therefore take part in everything from planning to production and from machines to the knowledge of people. To ensure the quality of the processes, Teampac uses a certified medical device management system ISO 13485. Teampac handles production from the idea to the finished product—whether it's a completely new product series or an update of an existing product family. The production of an existing product can also be transferred to us. Teampac can be responsible for the entire production chain of creating a product from concept to shelf or, if desired, a part of it, whenever necessary. The quality of our production and almost 100 percent delivery reliability guarantee our customers a very stable and reliable partner. More than 70 percent of our production is exported, with direct export to approximately 20 countries. Products manufactured by Teampac are used across the continents. We have strong expertise in infection prevention and wound care requirements of healthcare, so we are able to offer our 34| June 2023|www.insightscare.com

37. customers the best product solutions. We have succeeded in our work when the customer smiles and is satisfied with what we have achieved together! In Q1 of 2023, we will also implement ISO 14001 environmental certification for our operations. What would be your advice to budding entrepreneurs aspiring to venture into healthcare? Shed some light on your offerings and how they impact the healthcare industry as well as your clients. The healthcare care sector is an interesting area where customer relationships are normally long, but at the same time the threshold to enter the sector is very difficult due to the large initial investments in technology and expert organization. It is also good to keep in mind that product development is long-term and time-consuming. We manufacture a wide range of products for healthcare needs, e.g., for disinfecting and cleaning surfaces and skin, starting with patient wipes, adhesive remover, stoma and wound cleaning products. We manufacture wet wipes both individually packaged (single sachets) and in multipacks (flowpacks). In the future, all these claims will increase even more due to increasing regulation. Getting to the market requires long- term work and belief in one's own skills. We also deliver liquid-based products like lotions, intimate gels, lubricants, toothpaste, shampoos, and ultrasound gels in tubes, bottles, and jars. Our special expertise is Medical Device products, for which we support the customer throughout the entire production process. How do you envision scaling your organization's operations and offerings in 2023 and beyond? What are the elements that define Teampac's success and a wide customer reach today? The last few years have been a real time of growth and development for Teampac. We have worked hard for our common goal, which is to always support our customer's business in the best possible way, and this is how we will operate in the future as well. At Teampac, the quality of our work comes from the contribution of each of our employees. Quality must therefore take part in everything from planning to production and from machines to the knowledge of people. To ensure the quality of the processes, Teampac uses a certified medical device management system ISO 13485, which covers product development, contract manufacturing and sales of medical devices. Stable growth and profitable operations have given Teampac the opportunity to continuously invest in people, know-how, and equipment. In the last three years, we have invested more than three million euros in premises, equipment and people. This gives us a stable situation to grow our operations and our offering to our customers. Teampac's vision is to be the leading contract manufacturer of healthcare products in Northern Europe. The goal is tough, but at the same time we know that we are heading in the right direction. With this certification we can manufacture CE-marked products. We also operate according to ISO 9001 standard, which analyzes our processes in working methods, decision-making models, division of responsibilities, and customer needs, and to achieve the set goals. 35| June 2023|www.insightscare.com