Covid-19 Testing Kits Report - IntellectPeritus

1. Sample Report on Corona virus (Covid-19) Diagnostic Testing Methods At IntellectPeritus, we have collected around 100 diagnostic kits (used in SARS-COV-2 diagnosis) and around 50 patent documents as sample report and have tried to put value added technology categories to generate specific insights quickly using our deliverable InnovigenceCorona®. We created few insights based on the details of sample report. If you are interested in complete or any customized report for SARS- COV-2 diagnostic kits please feel free to write to us. All rights reserved. No part of this work may be produced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or inclusion in any information storage and retrieval system, without the prior written permission of IntellectPeritus Services.

2. Introduction The COVID-19 pandemic, also known as the corona virus pandemic, is an ongoing pandemic of corona virus disease 2019 (COVID‑19) caused by severe acute respiratory syndrome corona virus 2 (SARS‑CoV‑2). Though several trials for candidate vaccines and potential therapies are underway, there is currently no cure, and in the absence of either proven effective therapy or a vaccine, diagnostic testing becomes a valuable tool. Testing is our window onto the pandemic and how it is spreading. Without data on who is infected by the virus we have no way of understanding the pandemic. Without this data we cannot know which countries are doing well, and which are just underreporting cases and deaths. At IntellectPeritus, we have collected around 100 diagnostic kits (used in SARS-COV-2 diagnosis) and around 50 patent documents as sample report and have tried to put value added technology categories to generate specific insights quickly using our deliverable “Innovigence Corona”. If you are interested in detailed or any customized report for SARS-COV-2 diagnostic kits please feel free to write to us at sales@intellectperitus.com To schedule online meeting/demo please visit https://intellectperitus.com/request_demo.php

3. Sample Product Details Sample Diagnostic Kits Approved by FDA (USA) as well as CE (Europe) 1. Real-Time Fluorescent RT-PCR Kit for Detecting SARS-CoV-2 Assignee BGI Genomics Co Ltd Real-Time Fluorescent RT-PCR kit for detecting 2019-nCoV(SARS-CoV-2) is a qualitative in vitro nucleic acid amplification assay used to detect SARS-CoV-2 using reverse transcription PCR Application Link Product Details Mapped Technology:

4. 2. Xpert Xpress SARS-CoV-2 Test Assignee Cepheid Inc Automated molecular Xpert Xpress SARS- CoV-2 test can be used for qualitative detection of SARS-CoV-2 Application Link Product Details Mapped Technology:

5. 3. SARS-CoV-2 Fluorescent PCR Kit Assignee Maccura Biotechnology LLC SARS-CoV-2 Fluorescent PCR Kit is qualitative assay that allows detection of nucleic acids in samples from patients who meet COVID-19 (coronavirus) Application Link Product Details Mapped Technology:

6. 4. TaqPath COVID-19 Combo Kit Assignee Thermo Fisher Scientific Inc TaqPath COVID-19 Combo Kit used for detection of ORF1ab, N, S of novel SARS- CoV-2 virus Application Link Product Details Mapped Technology:

7. 5. NeuMoDx SARS-CoV-2 Assay Assignee NeuMoDx Molecular Inc NeuMoDx SARS-CoV-2 Assay used for detection of SARS-CoV-2 Application Link Product Details Mapped Technology:

8. Sample Patent Details 1. CN111060691A Detecting COVID-19 of the fluorescent immunochromatographic device and use method thereof Shenzhen Bioeasy Biotechnology Co Ltd Title Assignee Publication Date 2020-04-24 Summary: Fluorescence immunochromatographic assay device for detecting novel coronavirus COVID-19 comprises (A) Test strip with sequentially connected sample pad, binding pad, reaction pad and water absorption pad, where (i) Binding pad is coated with (i.a) Novel coronavirus NP protein monoclonal antibody marked by europium microspheres (i.b) Rabbit IgG antibody marked by europium microspheres (ii) Reaction pad has detection line and quality control line sequentially arranged on it (ii.a) Detection line is coated with novel coronavirus/ SARS coronavirus NP protein monoclonal antibody (ii.b) Reaction pad is Millipore 180 nitrocellulose membrane (ii.c) Quality control line is coated with goat anti-rabbit IgG antibody (iii) Sample pad is glass fiber membrane or a nonwoven fabric or a filter paper subjected to an immersion treatment (B) Time-resolved fluoroimmunoassay analyzer Method of using fluorescence immunochromatographic device comprises: (A) Adding sample into sample diluent to obtain sample solution (i) Sample comprises nasopharyngeal swab, sputum, alveolar lavage, blood, urine (B) Adding proper amount of sample solution onto sample pad of test strip (C) Detecting by using time-resolved fluoroimmunoassay analyzer Mapped Technology:

9. 2. CN111024954A Colloidal gold immunity chromatography device of joint detection of COVID-19 antigen and antibody and its using method Title Assignee Shenzhen Bioeasy Biotechnology Co Ltd Publication Date 2020-04-17 Summary: Method of using colloidal gold immunochromatographic device comprises steps of: (1) Dripping proper amount of blood sample solution on sample pads of COVID-19 antigen detection test strip and COVID-19 antibody detection test strip (2) Judging after a period of time, whether sample contains novel coronavirus COVID-19 antigen and novel coronavirus COVID-19 antibody according to color development conditions of detection line and quality control line, where judgment method comprises following steps: (a) For COVID-19 antigen detection test strip (i) Positive: First quality control line and first detection line both present red bands: Indicates sample contains novel coronavirus COVID-19 antigen (ii) Negative: First quality control line presents red strip and first detection line does not present red strip indicates: Sample does not contain novel coronavirus COVID-19 antigen (iii) Failure: First quality control line and first detection line do not present red strips or only present red strips: Indicates COVID-19 antigen detection test strip is invalid (b) For COVID-19 antibody detection test strip (i) Positive: Second quality control line and second detection line both present red bands, and third detection line does not present red bands indicates: Sample contains novel coronavirus COVID-19 IgM antibody (ii) Second quality control line and third detection line both present red bands, and second detection line does not present red bands indicates: Sample contains the novel coronavirus COVID-19 IgG antibody (iii) Negative: Second quality control line presents red strip, and second detection line and third detection line do not present red strips indicates: Sample does not contain novel coronavirus COVID-19 antibody (iv) Failure: Second quality control line, second detection line and third detection line do not present red strips or second quality control line does not present red strips: Indicates COVID-19 antibody detection test strip is invalid Mapped Technology:

10. 3. CN110982944A Title Novel coronavirus visual temperature fast detection kit Institute of Animal Sciences of CAAS Assignee Publication Date 2020-04-10 Summary: Kit for visual constant-temperature rapid detection of novel coronavirus 2019-nCoV by LAMP method, comprising (1) Loop primers loop F and loop B as shown in SEQ ID NOS: 5-6 (2) Bst DNA polymerase (3) dNTPs (4) Trehalose (5) OG dye (6) Tris HCl (7) TrionX-100 and Mg-containing 2+At least one of reaction buffer (8) Standard positive template Method for detection of novel coronavirus 2019-nCoV for non-diagnostic purposes, comprising (1) Dissolve 50 mg of OG lyophilized reaction reagent in 650 [mu]l reaction buffer to obtain OG reaction reagent, where (a) Composition of the reaction buffer is as follows: Tris-HCl 20 mM, pH 8.8, MgSO 46 mM, Trion X-100 0.1 % (b) Optimal reaction condition for performing LAMP amplification reaction is: 60 DEGREE C for 30 minutes (2) Then add 20 [mu]l ddH2O to bottom of reaction tube (3) Add 20 [mu]l OG reagent, where (a) Composition of OG freeze-dried reaction reagent is as follows: Bst 4.0 DNA polymerase, 0.4U/[mu]l dNTPs, 0.2 [mu]M trehalose 10 %, primer F3 4 [mu]M, primer B3 4 [mu]M, primer FIP 32 [mu]M, primer BIP 32 [mu]M, loop primer LoopF 16 [mu]M, loop primer LoopB 16 [mu]M, Among them, primer F3, primer B3, primer FIP, primer BIP, The sequence of loop primer LoopF and loop primer LoopB are shown in SEQ ID NO: 1-6, respectively (4) Then add 20 [mu]l sample to be tested (5) Mix and add 10 [mu]l OG dye to carry out LAMP amplification reaction and color reaction (6) Amplification result judgment: if the reaction system changes from orange to green, it indicates test sample contains new coronavirus 2019-nCoV Mapped Technology:

11. 4. CN111074007A A constant-temperature amplification kit and primer probe set for detecting SARS-COV-2 virus Shanghai Difectome Testing Laboratory Co Ltd Title Assignee Publication Date 2020-04-28 Summary: Isothermal amplification kit for detecting SARS-COV-2 virus comprises (A) Inactivating lysate (B) Constant temperature amplification system consisting of (i) Reaction buffer Buffer A (ii) Magnesium acetate Buffer B (iii) Negative control (iv) Nuclease-free water (v) Primer probe set in dry powder form (vi) RAA enzyme in dry powder form whcih comprises (vi.a) Reverse transcriptase, strand displacement DNA polymerase, recombinase, single-stranded DNA binding protein, NFO enzyme (C) Nucleic acid detection test strip Mapped Technology:

12. 5. CN111089962A Colloidal gold kit for jointly detecting novel coronavirus IgM/IgG antibody and preparation method Zhongshan Bio-tech Co Ltd Title Assignee Publication Date 2020-05-01 Summary: Colloidal gold kit for joint detection of novel coronavirus IgM/IgG antibodies, comprising (A) Box body, adhesive bracket (1) located in box body, and sample pad (2) pasted on extension bracket (1) sequentially (B) Gold standard pad (3) contains gold label N protein, where (a) Gold-labeled N protein is novel coronavirus nucleocapsid protein labeled with colloidal gold containing 6xHis tags, where (a) Mouse anti 6xHis monoclonal antibody is coated on quality control line (43) (C) NC membrane (4) (D) Sample suction pad (5) (E) IgM detection line (41) coated with mouse anti-human U-chain monoclonal antibody (F) IgG detection are provided on side of NC membrane (4) near gold standard pad (3) Line (42), where (a) IgG detection mouse anti-human IgG monoclonal antibody is coated on line (42) (G) Quality control line (43) is provided on side of NC membrane (4) close to suction pad Mapped Technology:

13. Empowering Clients with strategic & customized “IP” solutions clubbed with industry leading Analytics Deliverable Platforms innovigenceCorona® & innovigenceCoronium® Landscape & Portfolio report includes insights representing various Patent Analytics Activities such as… Patent filing trend as over Timeline (Year) and geographical region (Including all family member patents & analyzed patents) Research Country Analysis (Invention Origin Country) and Competition/Marketing Country Analysis as geographical coverage over Time (filing) & Assignee Assignee Analysis as Top Assignees, Top Assignee filing trend, Filing Assignee/Organization type, Assignee - Law firm association all including Parent-subsidiary relationship criteria Inventor Analysis as Key Inventor(s) filing over geographical region & with Assignee(s) and Independent / Self Inventors Prosecution Analysis as Assignee Portfolio (Granted & Pending), Assignee Analysis Over Country Wise Granted Patents and Assignee Analysis Over Correspondent Patent Class Analysis as Cooperative Patent Classification (CPC) (Top over Timeline, Assignee & definition) and International Patent Classification (IPC) (Top over Timeline, Assignee & definition) Technology over top assignee trends Technology Co-occurrence Matrix provides facility for easily identify the patents / patent filings which are claiming more than one technology categories

14. ABOUT US: IntellectPeritus is a recognized IP, Technology & Legal consulting company, assisting world leading organizations and IAM law firms with the finest quality of results, reliable, on demand & on time comprehensive solutions & strategies to support clients’ business challenges and opportunities. Our eminent focus on providing excellent quality of research & analysis (patent & non-patent) clubbed with interactive, secure, web based industry leading tools InnovigenceCoronium® & InnovigenceCorona® to all our clients, with only goal to fill the gap between quality analysis and interpretation of conclusive results to make smarter business decisions, by providing Innovative Intelligence (INNOVIGENCE®), that you can trust. OUR SERVICES: Experts in exploring Innovigence® available deep inside of your patents GLOBAL PATENT & NPL SEARCH Novelty, Patentability, Prior-art, Invalidation, Freedom-to-Operate, Clearance, Evidence of use, Infringement, Chemical Structure, Bio-sequence PATENT FILING & PROSECUTION Patent drafting, Patent application filing (Nation phase, PCT, India), Patent Office Action Response (OAR) IP ANALYTICS & RESEARCH Landscape analysis, Portfolio analysis, Patent-to-Product mapping, Technology / Competitor watch, Technology co-occurrence / white-space analysis TRADEMARKS / DESIGNS Trademark and designs searching, Filing / registration, monitoring & opposition response SURAT, INDIA | ONTARIO, CANADA Phone: (IN) +91-910-656-7571 (US/CA) +1-832-426-3606 (EP/UK) +44-208-123-0830 Email: info@intellectperitus.com | Website: www.intellectperitus.com