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Los Elementos y Moléculas de la Vida Losada, Vargas, Florencio y De la Rosa (1998-9)

Los Elementos y Moléculas de la Vida Losada, Vargas, Florencio y De la Rosa (1998-9) Editorial Rueda, Madrid. James Watson (L) and Francis Crick (R), and the model they built of the structure of DNA in 1953. ÁCIDO DESOXIRRIBONUCLEICO. ....PcMolecule Lite (Demo)MolsDNA.mcm.

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Los Elementos y Moléculas de la Vida Losada, Vargas, Florencio y De la Rosa (1998-9)

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  1. Los Elementos y Moléculas de la Vida Losada, Vargas, Florencio y De la Rosa (1998-9) Editorial Rueda, Madrid

  2. James Watson (L) and Francis Crick (R), and the model they built of the structure of DNA in 1953

  3. ÁCIDO DESOXIRRIBONUCLEICO ..\..\PcMolecule Lite (Demo)\Mols\DNA.mcm ..\..\..\Mis documentos\webdpto\biomoleculas\biomodel\model1\INICIO.HTM Los Elementos y Moléculas de la Vida Losada, Vargas, Florencio y De la Rosa (1998-9) Editorial Rueda, Madrid

  4. Los Elementos y Moléculas de la Vida Losada, Vargas, Florencio y De la Rosa (1998-9) Editorial Rueda, Madrid

  5. International Human Genome Sequencing Consortium Nature 409, 860 - 921 (2001)

  6. The automated production line for sample preparation at the Whitehead Institute, Center for Genome Research International Human Genome Sequencing Consortium Nature 409, 860 - 921 (2001)

  7. Conserved segments in the human and mouse genome Human chromosomes, with segmentscontaining at least two genes whose order is conserved in the mouse genome as colour blocks. Eachcolour corresponds to a particular mousechromosome. International Human Genome Sequencing Consortium Nature 409, 860 - 921 (2001)

  8. Distribution of the molecular functions of 26,383 human genes The sequence of Human Genome Venter et al. (2001) Science 291, 1304-1351

  9. Conservation of architectures between animal species International Human Genome Sequencing Consortium Nature 409, 860 - 921 (2001)

  10. The Helicobacter pylori chromosome Each color represents a different functional group of genes Tomb et al. (1997) Nature 388, 539

  11. Mycobacterium tuberculosis

  12. The first tree genome (Populus) will be sequenced by 2003 News in Nature (2002) 415, 724 - 725

  13. 8.2 Example mutants in Drosophila Mutations may cause only subtle changes or may produce significant changes in development, cellular function, appearance and/or behavior Figure 8-8

  14. Genes y Proteínas

  15. Interacciones Ác. nucleicos - Proteínas Fuertes (t = s, min) Nucleosoma (DNA) Ribosoma (RNA) Débiles (t = ms, ms) Polimerasas ..\..\..\Mis documentos\webdpto\biomoleculas\biomodel\model1\INICIO.HTM

  16. 9.5 Nucleosomes are complexes of histones Figure 9-30

  17. 9.5 The solenoid model of condensed chromatin Figure 9-31

  18. 9.6 A model for chromatin packing in metaphase chromosomes Figure 9-35

  19. 9.6 Chromosome number, size and shape at metaphase are species specific Figure 9-33

  20. 10.5 Transcriptional activators are modular proteins composed of distinct functional domains Figure 10-39

  21. DNA-binding domains can be classified into numerous structural types • Homeodomain proteins • Zinc-finger proteins • Winged-helix (forkhead) proteins • Leucine-zipper proteins • Helix-loop-helix proteins

  22. Interaction between azinc-finger protein and DNA

  23. Interaction of a homodimeric leucine-zipper protein and DNA

  24. Interaction of a helix-loop-helix in a homodimeric protein and DNA

  25. A new family of plant transcription factors displays a novel ssDNA-binding surface Whirligig tetrameric structure of p24 The p24 protomer Desveaux et al. (2002) Nature Struct Biol 9, 512

  26. A new family of plant transcription factors displays a novel ssDNA-binding surface Putative ssDNA-binding residues of a p24protomer, corresponding to the subunit shown in the lower lefthand corner of the left picture Binding of p24 to melted dsDNA Desveaux et al. (2002) Nature Struct Biol 9, 512

  27. Telomeres are protein–DNAstructures protecting the ends ofchromosomes Basics of the quadruplex topology of human telomeric repeat sequences D.J. Patel (2002) Nature 417, 807

  28. Structure of the quadruplex formed by the four-repeat TTAGGG human telomere DNAsequence. The central potassium counter ion is coordinated in abipyramidyl antiprismatic arrangement by the electronegative carbonyl groups of guanine O6 G.N. Parkinson et al. (2002) Nature 417, 876

  29. The folding and appearance of the telomeric DNA sequence is fundamentally different in K+- and Na+-containing quadruplexstructures a) The K+-stabilized crystal structure b) TheNa+-stabilized solution structure D.J. Patel (2002) Nature 417, 807

  30. Clinicalimplications. The enzyme telomerase is highly expressed only in tumour cells, enabling them tocarry on replicating their chromosomes almost indefinitely. (In non-tumour cells, by contrast,telomerase is not expressed and telomeres gradually erode to the point at which cells cannotduplicate their DNA safely, and so no longer divide.) So telomerase is a promising drug target.It binds to single-stranded telomere ends, and could potentially be inhibited by drugs thatcompete for these ends (in their quadruplex form). D.J. Patel (2002) Nature 417, 807

  31. ESTRUCTURA DEL DNA 5´ 3´ C G T A T A T A C G C G T A C G T A 3´ 5´

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