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Case Summary

Case Summary. 10 yr old female C.C.; intermittent abd. pain & lower abd. mass Wt loss of 4 Kg Huge abd. Mass on CT Mild hypercalcemia (11.4 mg/dL) CA-125 ↑. Most Common Cancers in Children. Clinical tumor markers. a -Fetoprotein b -hCG LDH CEA CA-125 CA-19-9. CA-125.

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Case Summary

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  1. Case Summary 10 yr old female C.C.; intermittent abd. pain & lower abd. mass Wt loss of 4 Kg Huge abd. Mass on CT Mild hypercalcemia (11.4 mg/dL) CA-125↑

  2. Most Common Cancers in Children

  3. Clinical tumor markers a-Fetoprotein b-hCG LDH CEA CA-125 CA-19-9

  4. CA-125 Gold standard tumor marker for the evaluation of pelvic masses Related to tissues of coelomic epithelium and Müllerian ducts Ovarian tumors of germ cell, epithelial and stromal origin

  5. Hypercalcemia in Cancer Patients Most common paraneoplastic syndrome Serum calcium ≥ 10.5 mg/dL Various symptoms and signs according to serum calcium level Marked hypercalcemia ≥ 13 mg/dL should be treated immediately

  6. Clinical Diagnosis R/O Malignant ovarian tumor with hypercalcemia

  7. Germ cell tumors Normal fetal yolk sac Germ cell production Primordial germ cell Migration Gonads Normal Abnormal Cell death Neoplastic cell Suppressed differentiation Differentiation Embryonic Extra-embryonic Germinoma (Seminoma) (Dysgerminoma) Embryonal carcinoma Matureor immature teratoma Choriocarcinoma Yolk sac tumor (EST)

  8. Small round blue cell tumor in childhood Non-Hodgkin lymphoma Neuroblastoma Rhabdomyosarcoma Ewing sarcoma/PNET

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