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Neurological Disease Ontology

Neurological Disease Ontology. Alexander Diehl University at Buffalo October 5, 2011. Ontologies for Neuroscience and Neurology. The Neurological Disease Ontology (ND) Based on the Ontology for General Medical Sciences Incorporates parts of NIF-Dysfunction and the Disease Ontology

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Neurological Disease Ontology

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  1. Neurological Disease Ontology Alexander Diehl University at Buffalo October 5, 2011

  2. Ontologies for Neuroscience and Neurology • The Neurological Disease Ontology (ND) • Based on the Ontology for General Medical Sciences • Incorporates parts of NIF-Dysfunction and the Disease Ontology • Three initial areas of focus • Dementia, in particular Alzheimers • Multiple Sclerosis • Stroke, Cerebralvascular events

  3. Ontology Development • Based on published existing ontologies as well as the scientific literature, including original articles, reviews, and text books • Ontology terms (classes) are given both textual and logical definitions. Logical definitions relate the term to terms in other ontologies.

  4. Ontology Development • Top-Down and Bottom-Up Approaches Utilized. • Top-Down starts with high level categories and fills in more specialized classes. • Bottom-Up looks at specific literature and sees what classes are needed to represent a domain.

  5. The Ontology for General Medical Sciences (OGMS)provides top level classes for the Neurology Disease Ontology.

  6. The Ontology for General Medical Sciences (OGMS)provides top level classes for the Neurology Disease Ontology.

  7. Bottom-Up (Annotation-Driven) Ontology Development Lancet (1998) 352:1498

  8. Bottom-Up (Annotation-Driven) Ontology Development Lancet (1998) 352:1498

  9. Bottom-Up (Annotation-Driven) Ontology Development Journal of Neuroimmunology (2007) 188:167

  10. Bottom-Up (Annotation-Driven) Ontology Development Journal of Neuroimmunology (2007) 188:167

  11. Bottom-Up (Annotation-Driven) Ontology Development Nature Genetics (2010) 42(6):495

  12. Bottom-Up (Annotation-Driven) Ontology Development Nature Genetics (2010) 42(6):495

  13. A Proto-MS Ontology

  14. Alexander Diehl addiehl@buffalo.edu Neurological Disease Ontology (MS, Dementia, Stroke) Mark Jensen, Alexander Cox, Bianca Weinstock-Guttman, KingaSzigiti, Alan Ruttenberg, Barry Smith

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