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BCG vaccine

Mycobacterium tuberculosis. The most prevalent human pathogenLatent infection9 million new cases/year2 million deaths / year. BCG vaccine. Only licensed vaccineMiliary TB and tuberculous meningitisNOT pulmonary TBStill very variableLooks like it's loosing immunogenicity. History. First trie

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BCG vaccine

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    1. BCG vaccine The good, the bad and the ugly

    2. Mycobacterium tuberculosis The most prevalent human pathogen Latent infection 9 million new cases/year 2 million deaths / year

    3. BCG vaccine Only licensed vaccine Miliary TB and tuberculous meningitis NOT pulmonary TB Still very variable Looks like it’s loosing immunogenicity

    4. History First tried in 1905 Succeeded in 1921 80% protection even against pulmonary TB Attenuation took 15 years No master stock until 1960s

    5. How it works (Overview) Attenuated Mycobacterium bovis, replication competent Induces strong TH1 response Strong enough to induce rapid granuloma Administered soon after birth or in childhood

    6. Attenuation Many deletions between M. bovis and BCG and between Mtb and BCG Called Regions of Difference (RD) Deletion of virulence factors ? RD1

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