1 / 31

Gene Regulation in Health in Disease (GRHD) Research Center of Excellence at CSU

Gene Regulation in Health in Disease (GRHD) Research Center of Excellence at CSU. GRHD Logo is “under construction” by CSU Art Department. Gene Regulation in Health in Disease (GRHD) Research Center of Excellence at CSU. GRHD: past, present and future. History of GRHD.

isanne
Download Presentation

Gene Regulation in Health in Disease (GRHD) Research Center of Excellence at CSU

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Gene Regulation in Health in Disease (GRHD) Research Center of Excellence at CSU GRHD Logo is “under construction” by CSU Art Department

  2. Gene Regulation in Health in Disease (GRHD) Research Center of Excellence at CSU GRHD: past, present and future History of GRHD Why GRHD is a Center/Cluster of Excellence? GRHD development/future

  3. Gene Regulation in Health in Disease (GRHD) Research Center of Excellence at CSU Center was launched in 2008 with $900,000 funding from the Ohio Third Frontier Commission’s Ohio Research Scholars Program. Initiative of the 4 co-founding GRHD members: Dr. Michael Kalafatis (CHM) Dr. Anton A. Komar (BIO) Dr. Barsanjit Mazumder (BIO) Dr. Crystal M. Weyman (BIO): co-founding director Currently brings together 15 faculty from 3 departments: BIO – 9 faculty; CHM – 5 faculty; PHS; 1 faculty

  4. Gene Regulation in Health in Disease (GRHD) Research Center of Excellence at CSU Vision Statement: To enhance and integrate research focused on Gene Regulation in Health and Disease leading to better understanding of the molecular mechanisms controlling these processes and the identification of therapeutic targets.

  5. Gene Regulation in Health in Disease (GRHD) Research Center of Excellence at CSU Mission Statement: To develop and support research focused on Gene Regulation in Health and Disease. To encourage and provide support mechanisms for the acquisition of extramural funding. To encourage and provide support mechanisms for the dissemination of research results. To create mechanisms to acquire resources to support research and student training focused on Gene Regulation in Health and Disease. To develop and expand partnerships with relevant public and private community entities with similar interests. To develop and promote Cleveland State University’s reputation as a local, national and international leader in Gene Regulation in Health and Disease.

  6. Gene Regulation in Health in Disease (GRHD) Research Center of Excellence at CSU External Advisory Committee: Paul DiCorleto, Ph.D.Staff, Institute ChairmanLerner Research Institute, Cleveland Clinic Richard W. Hanson, Ph.D.Leonard & Jean Skeggs Professor of BiochemistryDepartment of Biochemistry, CWRU School of Medicine Roy L. Silverstein, M.D.John and Linda Mellowes Professor and Chair, Department of MedicineProfessor of Cell Biology and Physiology, Medical College of Wisconsin George R. Stark, Ph.D.Distinguished Scientist, Cleveland ClinicMember of the U.S. National Academy of Science and Institute of Medicine and Fellow of the Royal Society of London Toni Scarpa, Ph.D. Former director of the Center for Scientific Review, NIH

  7. Gene Regulation in Health in Disease (GRHD) Research Center of Excellence at CSU Membership Criteria: Non-tenuredfaculty shall have a strong record of publication in peer-reviewed high impact scientific journals within the preceding five years. Tenuredfaculty shall additionally have the following within the preceding five years: (a) served as Principal Investigator on a national grant awarded to CSU and (b) published at least three peer-reviewed scientific manuscripts as a senior and/or corresponding author.

  8. Gene Regulation in Health in Disease (GRHD) Research Center of Excellence at CSU Membership Requirements: All members, if not currently funded by a national grant, shall submit at least one national grant per year. All members shall submit grants for internal review by at least two members of the GRHD executive committee or by one member of the executive committee and one nationally funded/distinguished scientist. All members are strongly encouraged to submit study section reviews of their grants to the GHRD executive committee for review and additional feedback. All members shall provide an annual research report to the executive committee detailing grant activity, manuscript submission/publication, invited seminars, poster presentations, service to the profession in the form of grant and manuscript review, and completion of doctoral dissertation, MS thesis and undergraduate independent study.

  9. GRHD faculty Aaron & Tony Faculty Andy & Bin Sailen Aimin & Xue-Long (Crystal, Michael, Barsan, Anton) + (Valentin, Girish, Bibo, Roman) year

  10. GRHD faculty Planning/Executive Committee Crystal M. Weyman BIO Anton A. Komar BIO Translational control of gene expression and protein folding. Apoptosis (cell death). Muscular dystrophy and cancer. Barsanjit Mazumder BIO Michael Kalafatis CHM Regulation of inflammation. Atherosclerosis. Blood coagulation and cancer.

  11. GRHD faculty Roman V. Kondratov BIO G. Valentin Boerner BIO Circadian system regulation, aging. Chromosome segregation during meiosis. Girish Shukla BIO Bibo Li BIO mRNA processing and stability in relation to prostate cancer. Telomere (sections of DNA at the ends of chromosomes) function.

  12. College Home • GRHD Home • External Advisory Committee • Lab Members • Membership • News • Mailing AddressCenter for Gene Regulationin Health and Disease (GRHD)2121 Euclid Avenue, SR 353Cleveland, OH 44115-2214 • Campus Location2351 Euclid Avenue Science and Research Bld., Room 353Phone: 216-687-5580Fax: 216.687.5549coshp@csuohio.edu • This site contains files that require the free Adobe Reader to view. GRHD faculty Xue-Long Sun CHM Aimin Zhou CHM Interferon and RNase L signaling. Diabetes, cancer. Glycoproteins. Chemistry of portein modifications. Antithrombotics. Andrew Resnick PHS Sailen Barik BIO Mechanotransduction response in epithelial cells. Biology of cilia. Cardiopulmonary Innate Immunity. Viral infections.

  13. College Home • GRHD Home • External Advisory Committee • Lab Members • Membership • News • Mailing AddressCenter for Gene Regulationin Health and Disease (GRHD)2121 Euclid Avenue, SR 353Cleveland, OH 44115-2214 • Campus Location2351 Euclid Avenue Science and Research Bld., Room 353Phone: 216-687-5580Fax: 216.687.5549coshp@csuohio.edu • This site contains files that require the free Adobe Reader to view. GRHD faculty Aaron F. Severson BIO Bin Su CHM Design and development of novel anticancer drugs. Chromosome dynamics, production of normal sperm and eggs. Anthony Berdis CHM DNA replication, nucleoside analogs,  cancer.

  14. GRHD: awards 2009-2013 Extramural funding, grants: NIH (R01, R15, R03, R21), NSF, HFSP,AHA, DoD, March of Dimes $11,837,417 total Private donations: Parker Hannifin Co. $1,850,000 total

  15. GRHD: indirect costs year-by-year GRHD brought to CSU $2,349,689 GHRD was entitled to 25% will be 20% starting 2014 $ year

  16. GRHD: awards 2009-2013 Extramural funding, grants: NIH (R01, R15, R03, R21), NSF, HFSP,AHA, DoD, March of Dimes $11,837,417 total Private donations: Parker Hannifin Co. $1,850,000 total

  17. 2009-2013

  18. 2009-2013

  19. 2009-2013

  20. GRHD publications/impact factor Web of Science: The most comprehensive and versatile research platform available

  21. *was ranked first in the nation in NIH funding in the category of Other Basic Sciences in 2004, when compared with peer departments at other medical schools.

  22. GRHD: present and future BUDGET: Indirect costs + 25K permanent budget: Before 2014: GRHD 25%; PIs 5% Starting 2014: GRHD 20%; PIs 10% GRHD 2014 projected indirects: ~$100,000 Covers pilot projects, serves as bridge funding, etc… GRHD permanent budget (provost funds): $25,000 Will continue to cover: invited speakers, printing costs, equipment emergency repair, etc…

  23. GRHD present and future Apart from aggressive grant submission strategy: Feb 5th deadline grants submitted: 3X R01s, AHA GiA, NSF (URM training grant; jointly with CWRU) GRHD is looking for private funding to support: Research of GRHD faculty: Pilot/innovative projects Bridge funding GRHD graduate students progress report seminar: Monday 12-1 pm GRHD distinguished/invited speakers seminar

  24. GRHD present and future Plans to address Corporations: STERIS, FISHER Scientific, AMRESCO, MPI biochemicals... Foundations: Ohio 3d Frontier Mt. Sinai Health Care Foundation The Rockefeller Foundation Short-term goal - to get ~$2M

  25. GRHD: web site will be re-designed

  26. GRHD: web site (will use CC as a model)

  27. GRHD: web site

  28. GRHD: logo will be designed by CSU art department

  29. GRHD publicity: Will be installed in the hallway close to the seminar room SR255 GRHD research news appearing on this display will be synchronized with GRHD research news appearing on GRHD web site GRHD research has led to 3 start-up companies

  30. GRHD technology transfer GRHD research has led to 3 start-up companies: DAPCEL, Inc 2008 (Komar, BIO, co-founder, CSO) www.dapcel.com Tiberian Biosciences & Pharmaceuticals, LLC2012 (Berdis, CHM, co-founder, CSO) http://www.tiberianbioscienceandpharma.com/ Kalafatis, LLC (name not finalized, in process of registration) (Kalafatis, CHM, co-founder, CSO)

More Related