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Oxygenoterapy normobaric toxicity

Oxygenoterapy normobaric toxicity c oncentrators tank atelectasis chemical respiratory drive zeolits membranous hyperbaric artificial ventilation acute – volume x pressure

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Oxygenoterapy normobaric toxicity

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  1. Oxygenoterapy normobaric toxicity concentratorstank atelectasis chemical respiratory drive zeolits membranous hyperbaric artificial ventilation acute – volume x pressure iron lung weaning chronic >3 weeks neoninvasive - mask, - rocking bed, elasticity of thorax

  2. Muscle fatigue blood flow teofylin rehabilitation temporary support

  3. ? A A rhytm generator B chemical feedback (chemoreceptors) C pattern of breathing (lung mechanoreceptors) D control of respiratory muscles (proprioreceptors)

  4. Metabolic demands = VO2, VCO2 Work of breathing Respiratory muscles

  5. Weil, Zwillich: Chest, 124, 1975

  6. WB VE = k VA VA V A VD VD VD f 16, pCO2 40f 32, pCO2 70 f 32, pCO2 40 WB Wel WR f

  7. Repiratory muscles Sitting - normal

  8. Sitting – C5

  9. Muscle power centr. drive WB

  10. Cough, hick up, voluntary control Disease COPD – pink puffers blue bloaters Chronic bronchitis - chronic hypercapnia Lung edema – J receptors Disturbances of the control Apneic pause Sleep – obstructive central SIDS – failure of chemical feed back CCHS, Ondin´scurse Weaning Mountain sickness – opposing stimuli

  11. COPD Blue blaters oxygenoterapy Pink puffers

  12. Spirometry, blood gases, pH   BB PP FVC 2.82 (4.22) 2.32 (3.64) FEV1 1.22 (3.14) 0.61 (3.12) PO2 52 58 pH 7.31 7.46 HCT 59% 44% ventilace? V/Q?

  13. Oxygenotherapy

  14. VE(l/min) 40 60 80 PCO2 (mmHg) 100 80 60 40 PO2 (mmHg)

  15. Apnoeas

  16. OSAS

  17. CSA

  18. Chemoreception sensitivity FRC Delay in sensory information

  19. CCHS, Ondin´scurse PHOX2B mutations Small CB

  20. Weaning drive metabolic alcalosis pattern of breathing Acute mountain sickness HAPE, HACE

  21. HACE

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