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Evaluation of the resistance of bacterial pathogens of synopulmonary infections in children. L.Chernyshova F.Lapiy National Medical Academy of Postgraduate Education (Kyiv, Ukraine). Background.
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Evaluationoftheresistanceofbacterialpathogens ofsynopulmonaryinfectionsinchildren L.Chernyshova F.Lapiy National Medical Academy of Postgraduate Education (Kyiv, Ukraine)
Background • Bacterial resistance creates a challenge for clinicians from the viewpoint of correct and successful management of patients. • Antibiotic resistance is an important consideration when treating bacterial infections and there is some evidence that resistance is becoming more widespread.
Background • Etiologic diagnosis is often unreliable; consequently, clinicians must know epidemiology of respiratory infections for optimizing empiric antibiotic therapy. • In recent years, all major respiratory bacterial pathogens have become more and more resistant to conventional antibiotics.
Background • S.pneumoniae andH.influenzae are the twomost important bacterial causes ofrespiratory infection. • Penicillins andmacrolides are the antibiotics mostcommonly used to treat such infections. • Penicillin-resistant and even multiresistantpneumococci have spread worldwide • Unfortunately, data on antibiotic resistance of S. pneumoniae or Hib in Ukraine are limited
Background • Pneumonia, septicemia, meningitis are considered an important public health problem in Ukraine • Lack of evidence of Hib disease burden in Ukraine has delayed the introduction of vaccines
Background • Hib conjugate vaccination was introduced in Ukraine in 2006. • Mortality from pneumonia, meningitis, septicemia decrease more then 2 time then Hib vaccination was introduced • According to the results of the case-control surveillance of Hib-vaccine effectiveness against pneumonia (sponsored by WHO) was more then 50%.
Background • Vaccination against pneumococcal infections in children has not been introduced in Ukraine • Healthcare providers have little information about pneumococcal infection (burden, resistence) and may not consider the vaccine a priority.
PCV vaccines in Ukraine • PCV7 conjugate vaccine was licensed in Ukraine in 2010 • PCV13 conjugate vaccine under registration
Objective • To investigate the pathogenic bacterial spectrum responsible for respiratory infections and their drug resistance in children.
Our plans • We are beginning research to study the burden of pneumococcal infection among children. • We plan to explore the serotypes of S.pneumoniae, susceptibility to antibiotics, the prevalence of carriage of S.pneumoniae.
Expected benefits • Information on the burden of pneumococcal infection, the prevalence of antibiotic-resistant strains will allow us to rationally use antibiotics in the treatment of respiratory infections and decide on the introduction of vaccination against pneumococcal infection