1 / 14

Lecture 4c 28 January 2013 Nutraceuticals and functional foods

Lecture 4c 28 January 2013 Nutraceuticals and functional foods. Group activity Nutraceuticals Type 1 -manage -lipids-triglycerides -diabetic neuropathy/nerve conduction velocity- evening primrose oil -fasting glucose down with fish oil.

ivan
Download Presentation

Lecture 4c 28 January 2013 Nutraceuticals and functional foods

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Lecture 4c 28 January 2013 Nutraceuticals and functional foods

  2. Group activity Nutraceuticals Type 1 -manage -lipids-triglycerides -diabetic neuropathy/nerve conduction velocity- evening primrose oil -fasting glucose down with fish oil

  3. Type 2- manage metabolic syndrome -obesity -lipids- elevated free fatty acids, triglycerides, cholesterol and LDL-cholesterol and small dense LDL, decreased HDLc, oxidation issues -blood pressure-elevated -platelet aggregation-elevated -insulin sensitivity-down

  4. OVERALL HYPOTHESIS GLA (DIETARY OIL) DGLA PLATELET INCREASED DGLA – PL - INCREASED PGE1 PGE1 IS (ANTI-AGGREGATORY, VASODILATORY) DECREASED AA-PL - TxA2 AND PGE2 (DECREASED) TxA2 IS (PRO-AGGREGATORY, VASOCONSTRICTORY) -PGE2 IS (PRO-AGGREGATORY, VASOCONSTRICTORY)

  5. Fish oil-triglycerides, fasting glucose, and glycosylated haemoglobin down, insulin receptor fluidity increases, platelets activity decreases Canola oil-improves insulin sensitivity Flax oil-lower dose (30 mg ALA/kg bw/d) -higher doses (178 mg ALA/kg bw/d) -no success

  6. Evening Primrose oil-no reports in diabetics found Borage oil-no reports in diabetics found Blackcurrant oil-no reports in diabetics found

  7. Prebiotics-inulin • –a complex carbohydrate may lower triglycerides and does lower LDL and total cholesterol • -proposed to increase insulin sensitivity • -both the lipid and the insulin sensitivity issues still need to be rigorously tested in human type 2 diabetics

  8. vitamin supplements- appears to be no need for these but this is being studied • chromium supplement increase insulin sensitivity but people are not normally chromium deficient • magnesium- deficiency associated with type 2 diabetes- • -supplement improves insulin sensitivity

  9. Central issues of functional foods versus nutraceuticals Concentration Purity-what is doing what Conflicting agents ?

  10. Type I diabetes-Functional foods Fish protein- lowers albuminuria Cows milk-concept of reverse functional foods nitrosamines-concept of reverse functional foods Soy proteins-potential attack on beta cells- concept of reverse functional foods

  11. Type 2 diabetes- functional foods Fish-lowers lipid oxidation-potential yet to be tested Tomatoes-lycopene- antioxidant-potential yet to be tested Green tea-flavonoids (eg catechins)-antioxidant potential- potential yet to be tested

  12. Soy-flavonoids- anti-oxidant- potential yet to be tested -hulls-improved glucose tolerance Garlic-allicin- lowers cholesterol and LDL cholesterol-potential yet to be tested

  13. Probiotics-chicory seed contains inulin and oligofructose-proposed to increase insulin sensitivity and improve lipid profiles (decreased triglycerides and LDL and cholesterol)

More Related