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Track A -- Basic Science Final Rapport

Track A -- Basic Science Final Rapport. Major themes in basic HIV/AIDS research that emerged at the XVII IAS Conference: Determinants of HIV transmission Cell restriction and genetic factors Any good news on the vaccine front?

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Track A -- Basic Science Final Rapport

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  1. Track A -- Basic ScienceFinal Rapport

  2. Major themes in basic HIV/AIDS research that emerged at the XVII IAS Conference: • Determinants of HIV transmission • Cell restriction and genetic factors • Any good news on the vaccine front? • Appreciation of the complexity of the interaction between HIV and the host immune system (i.e. is it time to re-visit the HIV immunology paradigm?)

  3. Better understanding of the determinant of HIV transmission: • The “extreme” genetic bottleneck observed during HIV transmission may be less severe in the event of “non-monogamous” infections. Role of STIs and mucosal inflammation? (Eric Hunter) • Role of animal models: is this an area where humanized mice may be particularly useful? (Garcia-Martinez & the BLT mice; Kish-Catalone & the humanized cervico-vaginal tissue model) • Transmission of CXCR4-tropic viruses (Petropoulos)

  4. Cell restriction & genetic factors • Host restriction factors: from TRIM5a and APOBEC3G to Tetherin and what else? (Mario Stevenson) • Complexity of the molecular interaction between HIV and host cells: siRNA library to identify cellular genes that restrict HIV replication in Jurkat cells (Jeang) • Use of double-fluorescent viruses, core-GFP + S15-Cherry-membrane, to study virus uncoating (Perez/Tom Hope)

  5. Any good news on the HIV vaccine front? • Improvement of DNA as an AIDS vaccine platforms by the use of electroporation and the addition of adjuvants such as IL-12, IL-15, etc (Boyer/Weiner) • The specificities of CD8+ T cell responses during primary HIV-1 infection appears to determine the later level of virus setpoint (Streeck/Altfeld) • Studies of “elite controllers” may be very informative-- role of virus fitness (Arts, Miura), cell restriction factors, and host immune system.

  6. Appreciation of the complexity of the interaction between HIV and the host immune system: • Pathogenic role of chronic immune activation in favoring HIV disease progression (Lisco/Margolis). • Studies of natural SIV infection in African Green monkeys (Gaufin/Apetrei) and Sooty Mangabeys. • Role of co-pathogens: is GBV-C a key to understand AIDS pathogenesis? (Stapleton) • PD-1, TIM3, and the “exhaustion” of HIV-specific T cell responses-- where do we go from here? (Conrad, Addo)

  7. Track A -- Basic ScienceFinal Rapport • A Special Thanks To: • Janelle Averill, Emily Blitz, Krista Newhouse • All the volunteers at the Rapporteur Office

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