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Nanomaterials as High Field MRI Contrast Agents

Ultra-short, single-walled carbon nanotubes e ncapsulating Gd 3+ and Dy 3+ were evaluated as intracellular agents for cell tracking at 21.1 T. Multimodal nanoprobes were constructed to target cerebrovascular amyloids (CVA) in the Diseased Alzheimer's Brain at 21.1 T.

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Nanomaterials as High Field MRI Contrast Agents

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  1. Ultra-short, single-walled carbon nanotubes encapsulating Gd3+ and Dy3+ were evaluated as intracellular agents for cell tracking at 21.1 T Multimodal nanoprobes were constructed to target cerebrovascular amyloids (CVA) in the Diseased Alzheimer's Brain at 21.1 T Nanomaterials as High FieldMRI Contrast Agents A B Take Home Message: Dy-nanotubes (DNTs) outperformed all existing contrast agents with respect to T2 and T2* at 21.1 T Take Home Message: Gd-based chitosan NPs with anti-amyloid antibodies (IgG4.1) identified CVA deposits in the transgenic AD mouse using fluorescence (A), SPECT (B) & high field MRI (C) C *Collaboration with FSU, U. Houston & Rice Univ. funded by UCGP, REU, American Heart Assoc. & Welch Found. *Collaboration with FSU, FAMU, U. Minnesota & Mayo Clinic funded by UCGP, American Heart Assoc. & Minn. Partnership for Biotechnology and Medical Genomics. Rosenberg JT, et al. 2014. Contrast Media Mol Imaging. 9(1): 92. Jaruszewski KM, et al. 2014. Biomaterials. 35(6): 1967.

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