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UsefulChem: An Open Notebook Science Project

UsefulChem: An Open Notebook Science Project. ASIS&T Panel : Opening Science to All: Implications of Blogs and Wikis for Social and Scholarly Scientific Communication. Jean-Claude Bradley. E-Learning Coordinator College of Arts and Sciences Associate Professor of Chemistry

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UsefulChem: An Open Notebook Science Project

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  1. UsefulChem: An Open Notebook Science Project ASIS&T Panel : Opening Science to All: Implications of Blogs and Wikis for Social and Scholarly Scientific Communication Jean-Claude Bradley E-Learning Coordinator College of Arts and Sciences Associate Professor of Chemistry Drexel University Oct 23, 2007

  2. Open and Closed Science Open Notebook Science (full transparency) Open Access Journal Article Traditional Journal Article OPEN Traditional Lab Notebook (unpublished) CLOSED

  3. Where is Science headed? WE ARE HERE

  4. How will this happen? • Self-organizing redundant processes • Agents can Read/Write with zero cost (free hosted services – e.g. Google) • Publication of all aspects of the scientific process: Open Notebook Science

  5. How can machines know what is important? Ask the humans

  6. UsefulChem Blog

  7. What chemists think is important in 2005

  8. Malaria is a Logical Application of Open Science • Very large problem: 300-500 million cases per year with one million deaths • Not a lucrative market: IP control less important

  9. Find-A-Drug

  10. Diketopiperazine Library First iteration: Solid Support Synthesis Evolves to: on pot Ugi reaction/cyclization

  11. The Molecules Blog

  12. The Experiments Blog

  13. Comments from peers

  14. The UsefulChem Wiki

  15. Telling the story of the failures

  16. Experiments moved to wiki

  17. Experiment History

  18. Experiment Edits

  19. Third Party Time-Stamp on Experiment Versions

  20. Monitoring experimental progress

  21. How are people finding our experiments?

  22. Molecules found by InChI

  23. Graphical Mining of Data with JSpecView usefulchem.wikispaces.com/Exp070 (48h 7 min)

  24. The blog as an integrative tool usefulchem.blogspot.com

  25. Processing Molecules on ChemSpider

  26. Open Primary Research in Drug Design using Web2.0 tools(blogs, wikis, Second Life, mailing lists) Rajarshi Guha Indiana U Tsu-Soo Tan Nanyang Inst. Docking JC Bradley Drexel U Synthesis Phil Rosenthal UCSF (malaria) Dan Zaharevitz NCI (tumors) Testing

  27. Mailing List Facilitates inter-group collaboration

  28. UsefulChem and Open Science in Second Life scifooliveson.wikispaces.com

  29. Question: Is it really a good thing to let anyone who thinks they have a scientific breakthrough have access to free, open, public, Googleable media? • YES • Question: What if I make a mistake in my data, never fix it, no one catches it, and then someone dies because a medical decision was based on my "findings"? Isn't this exactly why we have formal peer review in formal publications? • Peer review is not designed to catch errors from the analysis of raw data • Open Notebook Science is more difficult where human subjects are involved • Question: Who is the audience for science blogs and wikis anyway? Scientists or laypeople? • For UsefulChem, wiki is for chemists, blog for wider audience • Question: Can you get published if you've already posted your results to your blog/wiki? • We’ll find out…. • Question: Can scientists establish their credibilities/reputation by writing blogs and wikis? • Certainly we’ve found collaborators this way

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