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Autoimmune Disease

Autoimmune Disease. Rheumatoid Arthritis And Systemic Lupus Erythematosus. What is autoimmune disease?. Characteristics Inappropriate response of immune system Against self components Tissue destruction Sometimes fatal RA and SLE Autoantibody Immune complex. Rheumatoid Arthritis.

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Autoimmune Disease

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  1. Autoimmune Disease Rheumatoid Arthritis And Systemic Lupus Erythematosus

  2. What is autoimmune disease? • Characteristics • Inappropriate response of immune system • Against self components • Tissue destruction • Sometimes fatal • RA and SLE • Autoantibody • Immune complex

  3. Rheumatoid Arthritis • Mechanism • Rheumatoid factors • Binding with IgG (Fc part) • IgM-IgG complexes deposited in the joints • Type III hypersensitive 圖、 IgG結構 圖、Type III hypersensitive

  4. Typelll Hypersensitivity

  5. Rheumatoid Arthritis • Symptoms • Joints become red, swollen, painful, and tender • production of excessive joint fluid • Joints are usually inflamed in a symmetrical pattern • Loss of cartilage • Erosion and weakness of the bones

  6. SLE Mechanism -Type IIIhypersensitive

  7. SLE Symptoms • -Harms the heart, joints, • skin, lungs, blood vessel, • liver, kidneys, and nervous • system. • Is dubbed ” the great • imitators”. • -female:male=10:1

  8. 參考資料 • Thomas J. Kindt; Richard A. Goldsby. Immunology . Freeman. • http://www.medicinenet.com/rheumatoid_arthritis/page2.htm • http://en.wikipedia.org/wiki/Type_III_hypersensitivity • http://en.wikipedia.org/wiki/Immunoglobulin_G

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