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SOLVING ANXIETY Joseph LeDoux

SOLVING ANXIETY Joseph LeDoux. How Do We Prevent and Treat Anxiety? We go to the source. 20 million Americans (15%) suffer from anxiety disorders Anxiety exacerbates all other mental and medical problems Economic cost: > $50 billion per year (0.4 GDP)

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SOLVING ANXIETY Joseph LeDoux

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  1. SOLVING ANXIETY Joseph LeDoux

  2. How Do We Prevent and Treat Anxiety? We go to the source. 20 million Americans (15%) suffer from anxiety disorders Anxiety exacerbates all other mental and medical problems Economic cost: > $50 billion per year (0.4 GDP) Investing in the prevention and treatment of anxiety, especially in children, is the most efficient way to improve the health and well- being of our society

  3. NEURAL CIRCUIT MOLECULAR MECHANISMS Fear Conditioning SYNAPSE THREATENING STIMULUS CS Pathway US Pathway Somatosensory Cortex Auditory Cortex FIGHT FLIGHT RESPONSE AMYGDALA Auditory Thalamus Somatosens Thalamus LA B ITC AMYGDALA CE cs us FEAR RESPONSES CG LH PVN tone tone tone+shock FREEZING ANS HORMONES MUSCLE TENSION BLOOD PRESSURE RESPIRATION Fig 3

  4. Present and Future Goals drugs that eliminate memory in amygdala after remembering • Erasing traumatic memory • Finding neuronal markers of • individual differences in fear • Discovering new ways to • help children and adults • reduce anxiety so that • anxiety disorders don’t develop Structural, physiological, and genetic correlates of extreme fear in the amygdala Dampening amygdala activity by stress reduction techniques (controlled breathing)- shuts down fight-flight response Drugs or gene therapy that targets the amygdala

  5. The Emotional Brain Institutea research team focused on amygdalafear and anxiety NYU Washington Square NYU Langone Medical Center NY State Nathan Kline Institute

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