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Deadline = line + dead

Deadline = line + dead. think about it. deadline |ˈdedˌlīn| noun 1 this definition not relevant 2 historical a line drawn around a prison beyond which prisoners were liable to be shot.

jael-newton
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Deadline = line + dead

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  1. Deadline = line + dead think about it deadline |ˈdedˌlīn| noun 1 this definition not relevant 2 historical a line drawn around a prison beyond which prisoners were liable to be shot. Does it really make sense to designate that period at the end as the target as opposed to that at the beginning? Is it really the case that your schedule is such that all available times just happen to fall at the last minute?

  2. Beating Tamiflu • Themes: • Evolution: then and now • amino acids, mutations, folding: they matter

  3. How evolution happens • Good ideas are rewarded not sought/planned • There’s no mechanism for foresight, so it cannot be that way

  4. Just passin’ through http://www.ch.ic.ac.uk/local/projects/sanderson/images/lifecyc.gif

  5. Tamiflu: you shall not pass! a.k.a. oseltamivir http://en.wikipedia.org/wiki/File:Oseltamivir-3D-balls.png

  6. And it goes like this... Note: this is modeled, not a crystal structure http://www.ks.uiuc.edu/Research/influenza/

  7. Cell sorting • Laser is like a black light--molecules GLOW a different color than they are being hit with • In our case, GFP (green) and cherry (you guess it)

  8. Phylogenetic trees • Participants: to your spot on the tape! • Observers: watch & predict outcome and what it’s good for Each round: Copy any changes your parent already has Determine position of your new change by adding #s (0 = none) Randomly change to new base & mark (A, G, C, U) Turn to your kids & repeat

  9. Supplemental note • What we did was just the tip of the iceberg • among other things, the same basic thinking can be done to reconstruct a tree even if we only have the current [last] generation • try putting your thumb over any individual and seeing if you can guess their sequence by looking at their children

  10. Supplemental • Stuff you might find useful

  11. Supplemental • Cartoon of infections & tamiflu action (contr. Katie F12) • http://www.youtube.com/watch?v=0qCTyKrhVWc

  12. Unused • This was a graphical presentation of what we ended up doing ‘live’ in class. It tries to make the same points: the ‘correct’ reconstruction has fewer total changes (parent-child sequence alterations) than a random one

  13. Now what??? What information allows you to make good inferences about who is most related? Who gave rise to whom?

  14. Or this? Which makes sense?

  15. How about this?

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