Higher-order structure of chromosomes

1. Mateusz Skowron Paweł Ślusarczyk Supervisor: Joanna Deperas-Standyło Higher-order structure of chromosomes

2. Theory • Human lymphocyte cell nucleus – filled with 23 pairs of chromosomes containing DNA

3. Theory • Human lymphocyte cell nucleus – filled with 23 pairs of chromosomes containing DNA • Chromosomes in phase G0/G1 have form of long and screwed strings

4. Theory • Human lymphocyte cell nucleus – filled with 23 pairs of chromosomes containing DNA • Chromosomes in phase G0 / G1 have form of long and screwed strings • Firstly believed to form a chaotic spaghetti-like structure

5. Theory • Human lymphocyte cell nucleus – filled with 23 pairs of chromosomes containing DNA • Chromosomes in phase G0 / G1 have form of long and screwed strings • Firstly believed to form a chaotic spaghetti-like structure • 1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories

6. Theory • Human lymphocyte cell nucleus – filled with 23 pairs of chromosomes containing DNA • Chromosomes in phase G0 / G1 have form of long and screwed strings • Firstly believed to form a chaotic spaghetti-like structure • 1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories

7. Theory • Human lymphocyte cell nucleus – filled with 23 pairs of chromosomes containing DNA • Chromosomes in phase G0 / G1 have form of long and screwed strings • Firstly believed to form a chaotic spaghetti-like structure • 1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories

8. Theory • Human lymphocyte cell nucleus – filled with 23 pairs of chromosomes containing DNA • Chromosomes in phase G0 / G1 have form of long and screwed strings • Firstly believed to form a chaotic spaghetti-like structure • 1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories

9. Nucleus model • Nucleus – sphere • Chromosomal domain – sphere • Domains can overlap each other • Chromosomal domains in the nucleus

10. CHROMOSOME MODEL • Model chromosome – a chain of connected spheres • A real chromosome • Chromosomal territories in the nucleus • Spheres in each chromosome cannot overlap each other

11. Cпасибо for your attention!