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CHAPTER 8

CHAPTER 8. TRANSLATION OF LABORATORY, PILOT AND PLANT SCALE DATA. Data Required for Bioreactor Selection and Design. Microorganism species Growth and oxygen requirements Shear and rheology effects Sterility Volumetric output Light Foam Final use Cleaning and sterilizing

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CHAPTER 8

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  1. CHAPTER 8 TRANSLATION OF LABORATORY, PILOT AND PLANT SCALE DATA

  2. Data Required for Bioreactor Selection and Design • Microorganism species • Growth and oxygen requirements • Shear and rheology effects • Sterility • Volumetric output • Light • Foam • Final use • Cleaning and sterilizing • Heating and cooling • Materials of construction • Measurement Systems

  3. Definition of Scale Up The successful startup and operation of a commercial size unit whose design and operating procedures are in part based upon experimentation and demonstration at a smaller scale.

  4. The purpose of scale up is the selection design conditions and operational procedures to ensure that the effect of the different variables on the process is the same in units of different size. • Also to obtain similar yield

  5. Scale up Procedure • Similar Reynolds number or momentum factors. • Constant power consumption per unit volume of liquid, Pg/V • Constant impeller tip velocity, Ndi 4. Equal mixing and recirculation time, tm 5. Constant mass transfer coefficient, Kla

  6. Stirred Tank Design • Height:Diameter ratio between 2:1 to 6:1 • Fitted with baffles • 4 baffles if the tank diameter is less than 3 m • 6-8 baffles if the tank diameter larger than 3m • Width of baffles, T/10 and T/12

  7. Constant Power per Unit Volume • P/V determines the Reynolds number value • NDi determines the maximum shear stress • When the fluid in the tank is full turbulent, the power number is constant • P  N3Di5 • P/V  N3Di2 • (N3Di2)1 = (N3Di2)2

  8. Do all the examples given in class.

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