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Further Research The biochemical evidence was further supported by genetic evidence:

Further Research The biochemical evidence was further supported by genetic evidence: (1978) Dunn, Buzash-Pollert, and Studier: characterize a point mutation in the purine stretch upstream of T7 gene. Result: reduced level of protein synthesis (<10%).

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Further Research The biochemical evidence was further supported by genetic evidence:

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  1. Further Research • The biochemical evidence was further supported by genetic evidence: • (1978) Dunn, Buzash-Pollert, and Studier: characterize a point mutation in the purine stretch upstream of T7 gene. Result: reduced level of protein synthesis (<10%). • (1987) Jacob, Santer, and Dahlberg: observed overexpression and underexpression of certain proteins correlated with the extent of complementarity of their mRNA initiator regions to the new 16S sequence. • For more in depth information, please refer to the annotated version through Biography of an Experiment • Structural evidence and crystallography also support the rRNA-mRNA interaction

  2. The legacy • Steitz knew her paper would be influential as she began to design it; she introduced the idea of the mRNA-rRNA hybrid in scientific lectures and there was a lot of interest demonstrated within the field. • The paper’s evidence for an active role of the rRNA in the ribosomal placement on mRNA was instrumental to the current understanding of the ribosome as an RNA-based machine.

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