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Rapid, Multi-Analyte Immuno Biosensor with Passive Microfluidics:

Rapid, Multi-Analyte Immuno Biosensor with Passive Microfluidics: A Model System – Four Cardiac Marker Monitoring Device by Kyung A. Kang (Univ. of Louisville) and Chong Ahn (Univ. of Cincinnati). Requirements for a Functional Cardiac Marker Sensing System

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Rapid, Multi-Analyte Immuno Biosensor with Passive Microfluidics:

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  1. Rapid, Multi-Analyte Immuno Biosensor with Passive Microfluidics: A Model System – Four Cardiac Marker Monitoring Device by Kyung A. Kang (Univ. of Louisville) and Chong Ahn (Univ. of Cincinnati) Requirements for a Functional Cardiac Marker Sensing System (1) Real-Time Sensing; (2) High Sensitivity; (3) High Specificity; (4) Multi-Marker Sensing; (5) Automated Operation; (6) Cost Effectiveness Ahn’s Research Group Expertise Smart Bio-MEMS (1) Low Powered Micro-fluidics (Passive Flow in a Hydrophilic Chamber) (2) High Aspect Ratio by Rapid Thermal Chip Processing (3) Tight Sealing - Hydrophobic/ Hydrophobic Plastic Surface Patching (4) Easy to Fabricate Multiple Channels (5) Easy to Automate Kang’s Research Group Expertise Fiber Optic, Immuno- Biosensor (1) Highly Sensitive (< nano molar) (2) Highly Specific (discriminating other homologues in bio-system) (3) Rapid Measurements (~ minutes) (4) Cost-Effective (5) Portable Aim 1. Development of Four Separate Biosensors (months 0~18). Aim 2. Design of the Lab-on-a-Chip System for Fiber Optic Biosensing (months 0~12). Aim 3. Development of a Single Channel Microfluidic Module (months 7~18). Aim 4.Single Sensor Protocol Optimization/ Test Single Microfluidic System (months 19~30). Aim 5. Development of a Four-channel Microfluidic Module/Simultaneous Four Marker Measurements (months 19~36). (a) Expected Final Product: A Four Channel, Plastic Micro-Fluid Module: Multi-Channels with Multi-input and Output Ports for Real-Time, Simultaneous, Four Cardiac Maker-Assays. (a) Side and (b) Top views. (b) IMPACTS (1) Health Care – More Accurate Diagnosis/Prognosis for Better Patient Care (2) Tool for Environmental and Food Safety, and Anti-Bioterrorism (3) Multi-Disciplinary (Chemical-, Electrical-, Mechanical- Engr., Biochemistry, Chemistry, Medicine), Team Oriented, Undergraduate and Graduate Education

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