1 / 8

FANCD2 As A Key Player in Fanconi’s Anemia

Learn about FANCD2 as a key protein in Fanconi Anemia's DNA damage repair pathway, its phosphorylation, tumor suppressor role, and potential for cancer treatment. Explore its significance in research and experimental studies.

jameso
Download Presentation

FANCD2 As A Key Player in Fanconi’s Anemia

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. FANCD2 As A Key Player in Fanconi’s Anemia

  2. FANCD2 as a key protein in the FanconiAnemia (FA) DNA damage repair pathway

  3. Recruitment of FANCD2-FANCI complex to the stalled replication fork

  4. ATR-dependent phosphorylation at T691 and S717 enhances monoubiquitination

  5. FANCD2 as tumor suppressor protein in mice experiments

  6. Leu153Ser Mutation leads to the instability of the FANCD2 protein

  7. Inhibition of FANCD2 monoubiquitination to treat cancers Bortezomib

  8. http://emedicine.medscape.com/article/960401-overview • http://www.nature.com/articles/ncomms12124 • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051986/ • https://en.wikipedia.org/wiki/FANCD2 • http://www.tandfonline.com/doi/pdf/10.4161/cbt.3.6.929 • http://cancerres.aacrjournals.org/content/65/1/85 • https://www.omim.org/entry/613984 • http://www.sciencedirect.com/science/article/pii/S1097276513003808 • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592857/ • http://www.jbc.org/content/280/15/14877.full

More Related