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B9503207 陳又嘉 B9503212 林佳美

The Nobel Prize 1998 for their discoveries concerning nitric oxide (NO) as a signaling molecule in the cardiovascular system. B9503207 陳又嘉 B9503212 林佳美 B9503225 葉佳宜 B9503230 王馥陞 B9503232 蕭名傑 B9503233 張益嘉 B9403232 張瑜顯. (1.) Robert F.Furchgott

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B9503207 陳又嘉 B9503212 林佳美

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  1. The Nobel Prize1998for their discoveries concerning nitric oxide (NO) as a signaling molecule in the cardiovascular system B9503207陳又嘉 B9503212林佳美 B9503225葉佳宜 B9503230王馥陞B9503232蕭名傑 B9503233張益嘉 B9403232張瑜顯

  2. (1.) Robert F.Furchgott 1980 年自然期刊 (Nature) EDRF 內皮衍生之舒張因子 (endothelium-derived relaxing factor )

  3. (2) Ferid Murad • 1977 年環核甘酸研究期刊 (J Cycl Nucl Res) • 硝化甘油是經由釋放NO而使得血管平滑肌放鬆的

  4. (3) Louis J Ignarro • 1987年12月的美國國家科學院學報(Proc. Natl. Acad. Sci. USA) • prove that EDRF = NO

  5. NO in our life 1. air pollution 2. acid rain The function of NO 1. a signal passing material in never system 2. regulate blood pressure and the flow of blood

  6. (1) Furchgott acetylcholine EDRF

  7. (2) Murad • NO=========guanylate cyclase activatio • GTP=========cGMP guanylate cyclase

  8. (3) Louis J Ignarro Spectrophotometry Hemoglobin (yellow) exposed to endothelial cells that were stimulated to produce EDRF (green) Hemoglobin (yellow) directly exposed to NO (green)

  9. NO working mechanism

  10. Acetylcholine stimulates the endothelial cells to produce a factor, NO, which penetrates into and activates the muscle cells causing relaxation.

  11. (I) 血管內皮

  12. 控制一氧化氮製造量是調節一氧化氮活性的關鍵控制一氧化氮製造量是調節一氧化氮活性的關鍵 • 精胺酸 • 酶 (NOS) 抑制劑

  13. (II) 神經突觸

  14. For cardiovascular system • coronary artery • 冠狀動脈 • smooth muscle cells • 平滑肌細胞

  15. atherosclerotic coronary artery. • 冠狀動脈粥狀硬化 • angina pectoris • 心絞痛

  16. Nitroglycerin 硝化甘油

  17. 參考資料 • 1. http://www.medlib.ncku.edu.tw/people/1998.html2. http://www.tainandoctor.com/works_05.htm3. http://www.mednobel.ki.se/4. http://www.nobel.se/medicine/laureates/1998/illpres/enzyme.html5. http://www.nobel.se/medicine/laureates/1998/illpres/spectral.html6. http://www.nobel.se/medicine/laureates/1998/illpres/sandwich.html7. http://www.nobel.se/medicine/laureates/1998/illpres/index.html8. http://www.nobel.se/medicine/laureates/1998/illpres/medicine.html9. http://www.nobel.se/medicine/laureates/1998/illpres/application.html10.http://www.nobel.se/medicine/laureates/1998/press.html11.http://www.nobel.se/medicine/laureates/1998/medanim/images.html12.http://www.nobel.se/13.http://nobelprize.com/14.http:// www.infoplease.com/ipa/A0777579.html/15.http://www.accessexcellence.org/WN/SU/SU102001/nobelbio.html16.http://www.britannica.com/nobel/ 17.http://brc.se.fju.edu.tw/nobelist/199x/p1998.htm 18.http://www.biol.ntnu.edu.tw/doc/bill.htm

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