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BioMEMS, Bio-Nanotechnology, and Agricultural Research

BioMEMS, Bio-Nanotechnology, and Agricultural Research. Michael R. Ladisch, Rashid Bashir, Arun Bhunia Laboratory of Renewable Resources Engineering, Departments of ABE, ECE, BME and Food Science Schools of Agriculture and Engineering Purdue University. Multi-disciplinary. Agriculture.

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BioMEMS, Bio-Nanotechnology, and Agricultural Research

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  1. BioMEMS, Bio-Nanotechnology, and Agricultural Research Michael R. Ladisch, Rashid Bashir, Arun Bhunia Laboratory of Renewable Resources Engineering, Departments of ABE, ECE, BME and Food Science Schools of Agriculture and Engineering Purdue University

  2. Multi-disciplinary Agriculture Engineering Biotechnology Science Medicine

  3. Nanoscience and Nanotechnology Nanoscience: Fabrication, study and modeling of devices and structures where at least one dimension is 200 nm or smaller. Nanotechnology: Enables devices that are compact, portable, energy efficient, integrate sensing, and carry out complex functions of a full-scale laboratory BioMEMS Bio electromechanical systems

  4. Human Hair 75 µm Plant and Animal Cells Most Bacteria Lysozyme 0.18µm Transistor Virus Nanotechnology Proteins Carbon Nano-tubes Atoms Nanotechnology: Size and Scale 100µm 10µm 1µm Feature Size 100nm 10nm 1nm 0.1nm Cooper, 2001

  5. Nanotechnology Nano-Robots Semiconductor Technology Molecular Electronics “Wearable” Wireless Internet Appliances Vacuum Tube Technology Cell Phones The Internet Performance Computers Television Transistor Radio Radar Radio 1900 1950 2000 2050 Time Evolution of Technologies Cooper, 2001

  6. Micro-Mechanical Systems (MEMS) Electronic Nanotechnology Microfluidics & Bio-Chips Branches of Nanotechnology

  7. 10 mm Biochip: Smaller than a Postage stamp sealed channels and wells (volume of 1 to 10 nL/well) electrodes for detection connecting pads fluidic I/O ports Bashir et al.

  8. Role of Biotechnology Provides Bioreceptors Biomarkers (targets) Knowledge of mechanisms Interfaces macro- and nano-worlds Templates for design of small devices

  9. DNA mRNA Protein Information Component for Machine Polymer of Amino Acids Information Assembly Point Disbands

  10. Opportunities for Research Design and Assemble Technology Platform Chips Receptors Bioseparations Signal Transduction Interface Hardware and Software Component Assembly and Packaging

  11. Technology Issues We must know: Target molecule and its receptor Threshhold for detection (sensitivity) We must achieve: Rapid sampling and conditioning Specificity for target over biomolecules High signal to noise

  12. The Vision Detect Gene Expression Products Applications Food, Agriculture Biosecurity Animal Health Medicine Research, Industry, Hospital, Home

  13. Applications in Agriculture For Example-What is the cost of undetected pathogens? Food Products $13.1 billion in soda pop 7.5 billion in breakfast cereals 60.0 billion in fresh meats Branded meats, precooked products, micro-waveable red meats Livestock, poultry Sales figures from Kilman, Wall Street Journal, Feb 20, 2002

  14. BioMEMS - Devices and Systems Combine micro and nano devices with biology at the molecular level Implanted Diagnostic and Therapeutic Devices Organs Implants Pacemaker Tissues Drug Delivery Drug Delivery Polymers Bottoms-Up Biochips Nano-bio Organic/Biological Inorganic

  15. Specific Objectives of National Research Program 1. Identify systems unique to agriculture (cell membranes, starches, cellulose, oils) 2. Study biology of self-assembly processes 3. Apply to design, fabrication of BioMEMS a. Tubes b. Channels c. Surfaces Case studies must be agriculturally related

  16. Potential Outcomes and Impacts • Bio-inspired design of inorganic devices • Methods for mass-producing components for BioMEMS through agriculture a. A new fiber (cotton?) industry b. Self assembling oils c. Bio-based materials 3. Sampling methods and detection of pathogens

  17. Research Budget Estimate • Bio-inspired assembly processes $ 1 million / year • Methods for assembling nano-components into micro-devices $1 million /year • Applications testing in the field $ 1 million / year

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