Drug Discovery Process

Aug 07, 2012

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Dalla malattia al bersaglio biologico. La progettazione di un nuovo farmaco deve derivare da una necessit terapeutica (disease selection)Individuata la malattia, individuare il gene responsabile della disfunzione (gene to function)Individuata la funzione fisiologica compromessa, risalire alla pro

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Drug Discovery Process

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Presentation Transcript

1. Drug Discovery Process

Drug discovery and development

Drug discovery and development. Ian Hughes, i.e.hughes@leeds.ac.uk Objectives of next 5 lectures: you will: be aware of why/how new drugs are discovered know the processes involved in drug discovery and development see where pharmacologists/bioscientists may contribute

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DRUG DISCOVERY – NEW DRUG DEVELOPMENT PROCESS

DRUG DISCOVERY – NEW DRUG DEVELOPMENT PROCESS. BY. Dr. BASAVARAJ K. NANJWADE. Department of Pharmaceutics K L E UNIVERSITY JN MEDICAL COLLEGE BELGAUM – 590010 E-mail: bknanjwade@yahoo.co.in. DRUG.

1.59k views • 55 slides

Drug design and discovery

New and old drugs. Drug design and discovery. New drugs: penicillin 1928 Alexander Fleming. Secondary stage rash in syphylis on the palms of the hands. Bacteria Treponema pallidum. Old drugs: treated with arsenic and mercury. Adverse side effects:

1.11k views • 32 slides

Drug Discovery: an Industrial Process

Drug Discovery: an Industrial Process. How are drugs discovered and developed?. Dr Steve Carney, s.carney@elsevier.com Managing Editor, Drug Discovery Today. What’s my background?. First degree in Biochemistry PhD in Medical Biochemistry and Histopathology

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Drug Design / drug discovery

Drug Design / drug discovery. Jerome Baudry Assistant Professor BCMB UT/ORNL Center for Molecular Biophysics. 2 previous incarnations: Research faculty at UIUC Research scientist at Transtech Pharma, Inc. . Drug Design / drug discovery. What’s a drug?

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Drug Discovery

Drug Discovery. The use of solid phase combinatorial chemistry and parallel synthesis. Problems with Traditional Synthesis. 1 chemist 1 molecule Can only make one molecule at a time Each synthesis very time consuming Multistep syntheses have loss at each step

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The Pharmaceutical Industry and The Process of Drug Discovery

The Pharmaceutical Industry and The Process of Drug Discovery. What is a Drug? Types of Pharmaceutical Products What are the Important Disease Targets? How the Industry Has Evolved Drug Discovery and The Process of Getting a Drug to Market - an overview. What is a drug?.

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Process of Drug Discovery

Process of Drug Discovery. History …… Plant products pre-date the rise of modern medicine …… Use of opium, licorice, ephedra, marijuana, camellia, alcohol, digitalis, cocoa, quinine etc… …… First discovered was morphine (opium), which was found to be alkaline (1817)

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DRUG DISCOVERY

DRUG DISCOVERY. Random Search e.g., buying paintbrush, mop, hammer, gluestick, nail, etc. etc. for hanging a picture frame on the wall Rational Design e.g., buying a nail for hanging the frame Combinatorial Search

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Drug Design / drug discovery

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APPLICATIONS OF BIOINFORMATICS IN DRUG DISCOVERY AND PROCESS RESEARCH

APPLICATIONS OF BIOINFORMATICS IN DRUG DISCOVERY AND PROCESS RESEARCH. Dr. Basavaraj K. Nanjwade M.Pharm., Ph.D Associate Professor Department of Pharmaceutics JN Medical College KLE University, Belgaum- 590010. Bioinformatics.

660 views • 41 slides

Drug Discovery & Development

Drug Discovery & Development. PHC 311. LEC. 3 Sunday 9/ 11/ 1434H. Drug Optimization: Strategies in drug design I-optimizing drug target interactions.

1.26k views • 33 slides

Drug Discovery Process

Drug Discovery Process. Massimiliano Beltramo, PhD. Drug Discovery Process. Aim of the two lessons : To give an overview of the drug discovery process. At the end of the lessons you will gain a general idea of the steps necessary to move a new drug from the bench to the bedside.

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Drug discovery screening services

We offer the drug discovery screening services for early stages of new drug development process including drug target identification, hit-to-lead development and lead optimization. For more information visit us at: https://www.abeomics.com/

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18 Drug Discovery Process

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Drug discovery and development

379 views • 31 slides

Drug Discovery and Development

Drug Discovery and Development. How are drugs discovered and developed?. Basic Steps. Choose a disease Choose a drug target Identify a “bioassay” bioassay = A test used to determine biological activity. Find a “lead compound”

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Antifungal drug discovery.

Antifungal drug discovery. Jem Stach. Fungal Infections. Fungi have emerged as the fourth most common hospital bloodstream infections. Nearly 40% of which prove fatal - particularly significant in patients that are immunocompromised. Resistance to existing classes of drugs is on the increase

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Drug discovery informatics market

Drug discovery informatics is a method which generates large amount of data and information on drug and diseases which is used for research and development. It is usually used to speed up the screening drug molecules. Drug discovery informatics creates correct real- time data and increase the speed of the drug innovation process. Rising chronic diseases like cancer, diabetes etc. is the major factor fuelling the market.

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7-Step Process Followed By Drug Discovery Services

Drug discovery services need to follow a structured process to achieve the best possible results. Here is a brief overview of the process followed by CROs.

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Drug Discovery

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Drug Discovery Market

The global drug discovery market size grew from $85.42 billion in 2022 to $98.48 billion in 2023 at a compound annual growth rate (CAGR) of 15.3%. The drug discovery market size is expected to grow to $158.67 billion in 2027 at a CAGR of 12.7%.

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Drug Discovery Process

Drug Discovery Process

Presentation Transcript

Drug discovery and development

DRUG DISCOVERY – NEW DRUG DEVELOPMENT PROCESS

Drug design and discovery

Drug Discovery: an Industrial Process

Drug Design / drug discovery

Drug Discovery

The Pharmaceutical Industry and The Process of Drug Discovery

Process of Drug Discovery

DRUG DISCOVERY

Drug Design / drug discovery

APPLICATIONS OF BIOINFORMATICS IN DRUG DISCOVERY AND PROCESS RESEARCH

Drug Discovery &amp; Development

Drug Discovery Process

Drug discovery screening services

18 Drug Discovery Process

Drug discovery and development

Drug Discovery and Development

Antifungal drug discovery.

Drug discovery informatics market

7-Step Process Followed By Drug Discovery Services

Drug Discovery

Drug Discovery Market

Drug Discovery & Development