Ralph H. B. Benedict, Ph.D., ABPP-CN Associate Professor of Neurology and Psychiatry SUNY Buffalo School of Medicine Jac

1. Ralph H. B. Benedict, Ph.D., ABPP-CN Associate Professor of Neurology and Psychiatry SUNY Buffalo School of Medicine Jacobs Neurological Institute

2. Outline

3. MS: MRI T2

5. NP Profiles in MS Comment on “subcortical dementia” concept – implies distinct and homogeneous patternComment on “subcortical dementia” concept – implies distinct and homogeneous pattern

7. Brain tissue volume (contour – CSF) Outer contour of brain surface

13. Screening for MS Cognitive Impairment using a Self-Administered 15-Item QuestionnaireBenedict et al. Multiple Sclerosis. 2003; 9:95-101

14. easily distracted lose focus when listening slowed problem solving trouble describing programs recently watched forgetting appointments forgetting what is read instructions repeated reminded to do tasks forgetting errands difficulty answering questions difficulty tracking two things at once missing the point of conversations difficulty controlling impulses laugh/cry with little cause talk excessively MS Neuropsychological Screening Questionnaire (MSNQ)

15. Screening for MS Cognitive Impairment Using a Self-Administered 15-Item Questionnaire

16. Bayesian Probabilities, Informant Report MSNQ

17. Problems?

18. MSNQ Cross Validation - Methods

19. MSNQ Cross Validation - Reliability

20. MSNQ Cross Validation - Validity

21. MSNQ Cross Validation – Predictive Validity

24. Process:

25. Consensus: Psychometric Criteria

26. Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS)

27. Practice Effects, Alternate Forms

28. Brief Visuospatial Memory Test - Revised

29. MACFIMS Validation

32. Study Design

33. Regression Analysis Results

35. Neuropsychological Practice Guidelines

38. Thank You