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Gene Linkage Mapping in Chromosomes: Exploring Inheritance Patterns and Distance Estimation

This concept explores gene mapping and linkage in chromosomes, emphasizing how genes are located and inherited together. Topics include independent assortment, gene exchange during meiosis, inheritance variability, distance estimation, and conversion of crossover frequencies.

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Gene Linkage Mapping in Chromosomes: Exploring Inheritance Patterns and Distance Estimation

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  1. KEY CONCEPT Genes can be mapped to specific locations on chromosomes.

  2. Gene linkage was explained through fruit flies. • Morgan found that linked traits are on the same chromosome. • Chromosomes, not genes, assort independently during meiosis. Mutant Wild type

  3. Chromosomes exchange homologous genes during meiosis. • Linked genes are not inherited together every time.

  4. Linkage maps estimate distances between genes. • The closer together two genes are, the more likely they will be inherited together. • Cross-over frequencies are related to distances between genes. • Linkage maps show the relative locations of genes.

  5. Cross-over frequencies can be converted into map units. • gene A and gene B cross over 6.0 percent of the time • gene B and gene C cross over 12.5 percent of the time • gene A and gene C cross over 18.5 percent of the time

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